View in EDS HTML Full Text PDF Full Text

Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion.

Saved in:
Bibliographic Details
Title: Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion.
Authors: Zynda, Aaron J. (AUTHOR), Trbovich, Alicia M. (AUTHOR), Kehinde, Faith (AUTHOR), Burley, Christopher (AUTHOR), Collins, Michael W. (AUTHOR), Okonkwo, David O. (AUTHOR), Mucha, Anne (AUTHOR), Ostop, Sarah (AUTHOR), Holland, Cyndi (AUTHOR), Perry, Courtney (AUTHOR), Womble, Melissa N. (AUTHOR), Jennings, Sabrina (AUTHOR), Fedor, Sheri (AUTHOR), Dollar, Christina (AUTHOR), Durfee, Kori J. (AUTHOR), Elbin, R. J. (AUTHOR), Kontos, Anthony P. (AUTHOR)
Source: Neurological Sciences. Aug2025, Vol. 46 Issue 8, p3909-3918. 10p.
Subjects: Autonomic nervous system, Brain injuries, Rate of perceived exertion, Medical function tests, Public health
Abstract: Objective: To compare autonomic nervous system (ANS) response using the Buffalo Concussion Bike Test (BCBT) between adult post-concussion patients with and without pre-existing and post-injury anxiety. Design: Cross-sectional cohort study of participants from the Targeted, Multidomain (T-MD) Treatment for Concussion Randomized Controlled Trial. Setting: Two concussion specialty clinics. Participants: Ages 18–49 years, 8 days to 6 months from injury, without a history of cardiovascular/neurological/vestibular disorders. 256 participants were eligible, 120 declined, 136 enrolled, and 30 were excluded. Exposures: Participants completed the BCBT at a baseline study visit following initial clinical evaluation. Main outcomes and measures: Number of BCBT stages completed and Visual Analogue Scale (VAS), heart rate (HR), blood pressure (BP), and Ratings of Perceived Exertion (RPE) pre- and post-BCBT. Results: 106 participants (age = 25.5 [12.5], 66 [62.3%] female) were included, 44 (41.5%) with pre-existing anxiety, 61 (57.6%) without pre-existing anxiety, 33 (31.1%) with post-injury anxiety, and 73 (68.9%) without post-injury anxiety. Eighteen (17.0%) were in both anxiety groups. Results supported a significant group x time interaction in participants with pre-existing anxiety for increased diastolic BP (F[1,97] = 5.03, p = 0.03) and VAS (F[1,99] = 5.05, p = 0.03) while controlling for covariates. Participants with pre-existing anxiety (median = 8[4]) and post-injury anxiety (median = 8[5]) completed fewer BCBT stages than those without pre-existing (median = 11[6], p < 0.01) and post-injury (median = 10[6], p = 0.03) anxiety. Conclusions: Adults with pre-existing and post-injury anxiety experienced altered physiological responses to exercise post-concussion and completed fewer stages of the BCBT. Anxiety should be considered by clinicians when interpreting findings from exercise intolerance tests such as the BCBT. Trial Registration: www.clinicaltrials.gov; identifier: NCT04549532; https://clinicaltrials.gov/study/NCT04549532 [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 186678265
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zynda%2C+Aaron+J%2E%22&quot;&gt;Zynda, Aaron J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Trbovich%2C+Alicia+M%2E%22&quot;&gt;Trbovich, Alicia M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kehinde%2C+Faith%22&quot;&gt;Kehinde, Faith&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Burley%2C+Christopher%22&quot;&gt;Burley, Christopher&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Collins%2C+Michael+W%2E%22&quot;&gt;Collins, Michael W.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Okonkwo%2C+David+O%2E%22&quot;&gt;Okonkwo, David O.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mucha%2C+Anne%22&quot;&gt;Mucha, Anne&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ostop%2C+Sarah%22&quot;&gt;Ostop, Sarah&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Holland%2C+Cyndi%22&quot;&gt;Holland, Cyndi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Perry%2C+Courtney%22&quot;&gt;Perry, Courtney&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Womble%2C+Melissa+N%2E%22&quot;&gt;Womble, Melissa N.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jennings%2C+Sabrina%22&quot;&gt;Jennings, Sabrina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fedor%2C+Sheri%22&quot;&gt;Fedor, Sheri&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dollar%2C+Christina%22&quot;&gt;Dollar, Christina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Durfee%2C+Kori+J%2E%22&quot;&gt;Durfee, Kori J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Elbin%2C+R%2E+J%2E%22&quot;&gt;Elbin, R. J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kontos%2C+Anthony+P%2E%22&quot;&gt;Kontos, Anthony P.&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Neurological+Sciences%22&quot;&gt;Neurological Sciences&lt;/searchLink&gt;. Aug2025, Vol. 46 Issue 8, p3909-3918. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Autonomic+nervous+system%22&quot;&gt;Autonomic nervous system&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain+injuries%22&quot;&gt;Brain injuries&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rate+of+perceived+exertion%22&quot;&gt;Rate of perceived exertion&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+function+tests%22&quot;&gt;Medical function tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Public+health%22&quot;&gt;Public health&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To compare autonomic nervous system (ANS) response using the Buffalo Concussion Bike Test (BCBT) between adult post-concussion patients with and without pre-existing and post-injury anxiety. Design: Cross-sectional cohort study of participants from the Targeted, Multidomain (T-MD) Treatment for Concussion Randomized Controlled Trial. Setting: Two concussion specialty clinics. Participants: Ages 18–49 years, 8 days to 6 months from injury, without a history of cardiovascular/neurological/vestibular disorders. 256 participants were eligible, 120 declined, 136 enrolled, and 30 were excluded. Exposures: Participants completed the BCBT at a baseline study visit following initial clinical evaluation. Main outcomes and measures: Number of BCBT stages completed and Visual Analogue Scale (VAS), heart rate (HR), blood pressure (BP), and Ratings of Perceived Exertion (RPE) pre- and post-BCBT. Results: 106 participants (age = 25.5 [12.5], 66 [62.3%] female) were included, 44 (41.5%) with pre-existing anxiety, 61 (57.6%) without pre-existing anxiety, 33 (31.1%) with post-injury anxiety, and 73 (68.9%) without post-injury anxiety. Eighteen (17.0%) were in both anxiety groups. Results supported a significant group x time interaction in participants with pre-existing anxiety for increased diastolic BP (F[1,97] = 5.03, p = 0.03) and VAS (F[1,99] = 5.05, p = 0.03) while controlling for covariates. Participants with pre-existing anxiety (median = 8[4]) and post-injury anxiety (median = 8[5]) completed fewer BCBT stages than those without pre-existing (median = 11[6], p &lt; 0.01) and post-injury (median = 10[6], p = 0.03) anxiety. Conclusions: Adults with pre-existing and post-injury anxiety experienced altered physiological responses to exercise post-concussion and completed fewer stages of the BCBT. Anxiety should be considered by clinicians when interpreting findings from exercise intolerance tests such as the BCBT. Trial Registration: www.clinicaltrials.gov; identifier: NCT04549532; https://clinicaltrials.gov/study/NCT04549532 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186678265
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-025-08204-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 3909
    Subjects:
      – SubjectFull: Autonomic nervous system
        Type: general
      – SubjectFull: Brain injuries
        Type: general
      – SubjectFull: Rate of perceived exertion
        Type: general
      – SubjectFull: Medical function tests
        Type: general
      – SubjectFull: Public health
        Type: general
    Titles:
      – TitleFull: Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zynda, Aaron J.
      – PersonEntity:
          Name:
            NameFull: Trbovich, Alicia M.
      – PersonEntity:
          Name:
            NameFull: Kehinde, Faith
      – PersonEntity:
          Name:
            NameFull: Burley, Christopher
      – PersonEntity:
          Name:
            NameFull: Collins, Michael W.
      – PersonEntity:
          Name:
            NameFull: Okonkwo, David O.
      – PersonEntity:
          Name:
            NameFull: Mucha, Anne
      – PersonEntity:
          Name:
            NameFull: Ostop, Sarah
      – PersonEntity:
          Name:
            NameFull: Holland, Cyndi
      – PersonEntity:
          Name:
            NameFull: Perry, Courtney
      – PersonEntity:
          Name:
            NameFull: Womble, Melissa N.
      – PersonEntity:
          Name:
            NameFull: Jennings, Sabrina
      – PersonEntity:
          Name:
            NameFull: Fedor, Sheri
      – PersonEntity:
          Name:
            NameFull: Dollar, Christina
      – PersonEntity:
          Name:
            NameFull: Durfee, Kori J.
      – PersonEntity:
          Name:
            NameFull: Elbin, R. J.
      – PersonEntity:
          Name:
            NameFull: Kontos, Anthony P.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 46
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1