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Magnetic Resonance-guided Laser interstitial thermal therapy (MR-gLiTT) in Pediatric Neurosurgery: italian perspective and literature review.

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Title: Magnetic Resonance-guided Laser interstitial thermal therapy (MR-gLiTT) in Pediatric Neurosurgery: italian perspective and literature review.
Authors: Vitulli, Francesca (AUTHOR), Tortora, Domenico (AUTHOR), Pacetti, Mattia (AUTHOR), Spacca, Barbara (AUTHOR), Agushi, Rina (AUTHOR), Tamburrini, Gianpiero (AUTHOR), Nobili, Lino (AUTHOR), Cognolato, Erica (AUTHOR), Genitori, Lorenzo (AUTHOR), Giordano, Flavio (AUTHOR), Piatelli, Gianluca (AUTHOR), Consales, Alessandro (AUTHOR)
Source: Neurological Sciences. Aug2025, Vol. 46 Issue 8, p3965-3972. 8p.
Subjects: Focal cortical dysplasia, Medical sciences, Neurological disorders, Child patients, Partial epilepsy
Abstract: Introduction: Magnetic Resonance-guided Laser interstitial Thermal Therapy (MR-gLiTT) has established itself as a minimally invasive neurosurgical approach for the treatment of various pediatric brain lesions, including tumors and epilepsy. Research question: The work is likely to focus on evaluating the efficacy, safety and applicability of MR-gLiTT while investigating its potential to minimize surgical risks, shorten recovery time and improve patient outcomes. Material and methods: This paper presents the results of a survey conducted in three leading italian pediatric hospitals to investigate the use of MR-gLiTT in pediatric patients with neurosurgical conditions. Data on patient demographics, primary diagnoses, MR-gLiTT parameters, perioperative complications and postoperative outcomes were collected and analysed. Results: A total of 29 pediatric patients were included in the analysis. The median age at diagnosis was 36 months, with a predominance of males (58.6%). The most common indications were hypothalamic hamartomas (41.4%) and focal cortical dysplasia (24.1%). Perioperative complications were transient in nature (17.2%), with focal muscle weakness being the most frequent, while only one patient experienced a permanent hypoadrenocorticism. The average hospital stay was 6.48 days, with a mean follow-up duration of 23.12 months. Discussion and Conclusions: The adoption of MR-gLiTT in pediatric neurosurgery offers a promising minimally invasive approach with favorable outcomes. The efficacy in treating various pediatric neurological conditions is evident, suggesting its potential to reduce surgical risks, shorten hospital stays, and improve patient quality of life. Further clinical trials and prospective studies are required to fully understand the advantages of MR-gLiTT in pediatric neurosurgery. Highlights: MR-gLiTT enables laser ablation in the brain without a craniotomy, reducing surgical risks and recovery time. It shows high success in treating focal epilepsies, particularly HH-associated epilepsy, with better seizure control compared to traditional methods. MR-gLiTT is effective for complex and drug-resistant epilepsy cases like TSC and insular epilepsy, offering fewer complications and faster recovery. It uses advanced thermal mapping and predictive algorithms for precise tissue ablation while protecting healthy brain areas. Complications include potential neurological issues and fiber misplacement, emphasizing the need for careful planning and patient counseling. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Magnetic Resonance-guided Laser interstitial thermal therapy (MR-gLiTT) in Pediatric Neurosurgery: italian perspective and literature review.
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Aug2025, Vol. 46 Issue 8, p3965-3972. 8p.
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  Data: Introduction: Magnetic Resonance-guided Laser interstitial Thermal Therapy (MR-gLiTT) has established itself as a minimally invasive neurosurgical approach for the treatment of various pediatric brain lesions, including tumors and epilepsy. Research question: The work is likely to focus on evaluating the efficacy, safety and applicability of MR-gLiTT while investigating its potential to minimize surgical risks, shorten recovery time and improve patient outcomes. Material and methods: This paper presents the results of a survey conducted in three leading italian pediatric hospitals to investigate the use of MR-gLiTT in pediatric patients with neurosurgical conditions. Data on patient demographics, primary diagnoses, MR-gLiTT parameters, perioperative complications and postoperative outcomes were collected and analysed. Results: A total of 29 pediatric patients were included in the analysis. The median age at diagnosis was 36 months, with a predominance of males (58.6%). The most common indications were hypothalamic hamartomas (41.4%) and focal cortical dysplasia (24.1%). Perioperative complications were transient in nature (17.2%), with focal muscle weakness being the most frequent, while only one patient experienced a permanent hypoadrenocorticism. The average hospital stay was 6.48 days, with a mean follow-up duration of 23.12 months. Discussion and Conclusions: The adoption of MR-gLiTT in pediatric neurosurgery offers a promising minimally invasive approach with favorable outcomes. The efficacy in treating various pediatric neurological conditions is evident, suggesting its potential to reduce surgical risks, shorten hospital stays, and improve patient quality of life. Further clinical trials and prospective studies are required to fully understand the advantages of MR-gLiTT in pediatric neurosurgery. Highlights: MR-gLiTT enables laser ablation in the brain without a craniotomy, reducing surgical risks and recovery time. It shows high success in treating focal epilepsies, particularly HH-associated epilepsy, with better seizure control compared to traditional methods. MR-gLiTT is effective for complex and drug-resistant epilepsy cases like TSC and insular epilepsy, offering fewer complications and faster recovery. It uses advanced thermal mapping and predictive algorithms for precise tissue ablation while protecting healthy brain areas. Complications include potential neurological issues and fiber misplacement, emphasizing the need for careful planning and patient counseling. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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