A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.
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| Title: | A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. |
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| Authors: | Baune, B. T. (AUTHOR), Fromme, S. E. (AUTHOR), Aberg, M. (AUTHOR), Adli, M. (AUTHOR), Afantitis, A. (AUTHOR), Akkouh, I. (AUTHOR), Andreassen, O. A. (AUTHOR), Angulo, C. (AUTHOR), Barlati, S. (AUTHOR), Brasso, C. (AUTHOR), Bucci, P. (AUTHOR), Budde, M. (AUTHOR), Buspavanich, P. (AUTHOR), Cavone, V. (AUTHOR), Demyttenaere, K. (AUTHOR), Diaz-Caneja, C. M. (AUTHOR), Dierssen, M. (AUTHOR), Djurovic, S. (AUTHOR), Driessen, M. (AUTHOR), Ebner-Priemer, U. W. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Aug2025, Vol. 275 Issue 5, p1453-1464. 12p. |
| Subjects: | Schizophrenia, Bipolar disorder, Drug resistance, Pharmacogenomics, Mental illness, Individualized medicine, Mental depression |
| Abstract: | Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 186711336 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Baune%2C+B%2E+T%2E%22">Baune, B. T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fromme%2C+S%2E+E%2E%22">Fromme, S. E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aberg%2C+M%2E%22">Aberg, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adli%2C+M%2E%22">Adli, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Afantitis%2C+A%2E%22">Afantitis, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akkouh%2C+I%2E%22">Akkouh, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andreassen%2C+O%2E+A%2E%22">Andreassen, O. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Angulo%2C+C%2E%22">Angulo, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barlati%2C+S%2E%22">Barlati, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brasso%2C+C%2E%22">Brasso, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bucci%2C+P%2E%22">Bucci, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Budde%2C+M%2E%22">Budde, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buspavanich%2C+P%2E%22">Buspavanich, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavone%2C+V%2E%22">Cavone, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Demyttenaere%2C+K%2E%22">Demyttenaere, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Diaz-Caneja%2C+C%2E+M%2E%22">Diaz-Caneja, C. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dierssen%2C+M%2E%22">Dierssen, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Djurovic%2C+S%2E%22">Djurovic, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Driessen%2C+M%2E%22">Driessen, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ebner-Priemer%2C+U%2E+W%2E%22">Ebner-Priemer, U. W.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Aug2025, Vol. 275 Issue 5, p1453-1464. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacogenomics%22">Pharmacogenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). The final focus of the project is based on patient empowerment, dissemination and education (step 6) as well as the development of a software for fast, effective and individualized treatment decisions (step 7). The project has the potential to change the current trial and error treatment approach towards an evidence-based individualized treatment setting that takes TR risk into account at an early stage. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-024-01944-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1453 Subjects: – SubjectFull: Schizophrenia Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Drug resistance Type: general – SubjectFull: Pharmacogenomics Type: general – SubjectFull: Mental illness Type: general – SubjectFull: Individualized medicine Type: general – SubjectFull: Mental depression Type: general Titles: – TitleFull: A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Baune, B. T. – PersonEntity: Name: NameFull: Fromme, S. E. – PersonEntity: Name: NameFull: Aberg, M. – PersonEntity: Name: NameFull: Adli, M. – PersonEntity: Name: NameFull: Afantitis, A. – PersonEntity: Name: NameFull: Akkouh, I. – PersonEntity: Name: NameFull: Andreassen, O. A. – PersonEntity: Name: NameFull: Angulo, C. – PersonEntity: Name: NameFull: Barlati, S. – PersonEntity: Name: NameFull: Brasso, C. – PersonEntity: Name: NameFull: Bucci, P. – PersonEntity: Name: NameFull: Budde, M. – PersonEntity: Name: NameFull: Buspavanich, P. – PersonEntity: Name: NameFull: Cavone, V. – PersonEntity: Name: NameFull: Demyttenaere, K. – PersonEntity: Name: NameFull: Diaz-Caneja, C. M. – PersonEntity: Name: NameFull: Dierssen, M. – PersonEntity: Name: NameFull: Djurovic, S. – PersonEntity: Name: NameFull: Driessen, M. – PersonEntity: Name: NameFull: Ebner-Priemer, U. W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 275 – Type: issue Value: 5 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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