Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study.

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Title: Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study.
Authors: Rioux, Mathilde (AUTHOR), Brasher, Penelope M.A. (AUTHOR), McKeown, Gabriel (AUTHOR), Yeates, Keith Owen (AUTHOR), Vranceanu, Ana-Maria (AUTHOR), Snell, Deborah L. (AUTHOR), Cairncross, Molly (AUTHOR), Panenka, William J. (AUTHOR), Iverson, Grant L. (AUTHOR), Debert, Chantel T. (AUTHOR), Bayley, Mark T. (AUTHOR), Hunt, Cindy (AUTHOR), Burke, Matthew J. (AUTHOR), Silverberg, Noah D. (AUTHOR)
Source: Neuropsychological Rehabilitation. Aug2025, Vol. 35 Issue 7, p1349-1365. 17p.
Subjects: Exposure therapy, Postconcussion syndrome, Avoidance (Psychology), Clinical trials, Disabilities, Brain injuries, Treatment effectiveness
Abstract: Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials. The GET + UC group (N = 34) received GET (delivered over 16 videoconference sessions) in addition to usual care (UC). The historical comparison group (N = 71) received UC only. PCS severity (Rivermead Post Concussion Symptoms Questionnaire; RPQ) and disability (World Health Organization Disability Assessment Schedule; WHODAS 2.0 12-item) were measured at clinic intake (M = 2.7, SD = 1.1 months after injury) and again at M = 4.9 (SD = 1.1) months after injury. Between-group differences were estimated using linear mixed effects regression, with a sensitivity analysis controlling for injury-to-assessment intervals. The estimated average change on the RPQ was −14.3 in the GET + UC group and −5.3 in the UC group. The estimated average change on the WHODAS was −5.3 in the GET + UC group and −3.2 in the UC group. Between-group differences post-treatment were −5.3 on the RPQ and −1.5 on the WHODAS. Treatment effects were larger in sensitivity analyses. Findings suggest that a randomized controlled trial is warranted. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
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Abstract:Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials. The GET + UC group (N = 34) received GET (delivered over 16 videoconference sessions) in addition to usual care (UC). The historical comparison group (N = 71) received UC only. PCS severity (Rivermead Post Concussion Symptoms Questionnaire; RPQ) and disability (World Health Organization Disability Assessment Schedule; WHODAS 2.0 12-item) were measured at clinic intake (M = 2.7, SD = 1.1 months after injury) and again at M = 4.9 (SD = 1.1) months after injury. Between-group differences were estimated using linear mixed effects regression, with a sensitivity analysis controlling for injury-to-assessment intervals. The estimated average change on the RPQ was −14.3 in the GET + UC group and −5.3 in the UC group. The estimated average change on the WHODAS was −5.3 in the GET + UC group and −3.2 in the UC group. Between-group differences post-treatment were −5.3 on the RPQ and −1.5 on the WHODAS. Treatment effects were larger in sensitivity analyses. Findings suggest that a randomized controlled trial is warranted. [ABSTRACT FROM AUTHOR]
ISSN:09602011
DOI:10.1080/09602011.2024.2403647