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Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study.

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Title: Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study.
Authors: Rioux, Mathilde (AUTHOR), Brasher, Penelope M.A. (AUTHOR), McKeown, Gabriel (AUTHOR), Yeates, Keith Owen (AUTHOR), Vranceanu, Ana-Maria (AUTHOR), Snell, Deborah L. (AUTHOR), Cairncross, Molly (AUTHOR), Panenka, William J. (AUTHOR), Iverson, Grant L. (AUTHOR), Debert, Chantel T. (AUTHOR), Bayley, Mark T. (AUTHOR), Hunt, Cindy (AUTHOR), Burke, Matthew J. (AUTHOR), Silverberg, Noah D. (AUTHOR)
Source: Neuropsychological Rehabilitation. Aug2025, Vol. 35 Issue 7, p1349-1365. 17p.
Subjects: Exposure therapy, Postconcussion syndrome, Avoidance (Psychology), Clinical trials, Disabilities, Brain injuries, Treatment effectiveness
Abstract: Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials. The GET + UC group (N = 34) received GET (delivered over 16 videoconference sessions) in addition to usual care (UC). The historical comparison group (N = 71) received UC only. PCS severity (Rivermead Post Concussion Symptoms Questionnaire; RPQ) and disability (World Health Organization Disability Assessment Schedule; WHODAS 2.0 12-item) were measured at clinic intake (M = 2.7, SD = 1.1 months after injury) and again at M = 4.9 (SD = 1.1) months after injury. Between-group differences were estimated using linear mixed effects regression, with a sensitivity analysis controlling for injury-to-assessment intervals. The estimated average change on the RPQ was −14.3 in the GET + UC group and −5.3 in the UC group. The estimated average change on the WHODAS was −5.3 in the GET + UC group and −3.2 in the UC group. Between-group differences post-treatment were −5.3 on the RPQ and −1.5 on the WHODAS. Treatment effects were larger in sensitivity analyses. Findings suggest that a randomized controlled trial is warranted. [ABSTRACT FROM AUTHOR]
Copyright of Neuropsychological Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Graded exposure therapy for adults with persistent symptoms after mTBI: A historical comparison study.
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  Data: <searchLink fieldCode="AR" term="%22Rioux%2C+Mathilde%22">Rioux, Mathilde</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brasher%2C+Penelope+M%2EA%2E%22">Brasher, Penelope M.A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McKeown%2C+Gabriel%22">McKeown, Gabriel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeates%2C+Keith+Owen%22">Yeates, Keith Owen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vranceanu%2C+Ana-Maria%22">Vranceanu, Ana-Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Snell%2C+Deborah+L%2E%22">Snell, Deborah L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cairncross%2C+Molly%22">Cairncross, Molly</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panenka%2C+William+J%2E%22">Panenka, William J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iverson%2C+Grant+L%2E%22">Iverson, Grant L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Debert%2C+Chantel+T%2E%22">Debert, Chantel T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bayley%2C+Mark+T%2E%22">Bayley, Mark T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hunt%2C+Cindy%22">Hunt, Cindy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burke%2C+Matthew+J%2E%22">Burke, Matthew J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silverberg%2C+Noah+D%2E%22">Silverberg, Noah D.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Exposure+therapy%22">Exposure therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Postconcussion+syndrome%22">Postconcussion syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Avoidance+%28Psychology%29%22">Avoidance (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Disabilities%22">Disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink>
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  Data: Fear avoidance behaviour is associated with slow recovery from mild traumatic brain injury (mTBI). This study is a preliminary evaluation of graded exposure therapy (GET), which directly targets fear avoidance behaviour, for reducing post-concussion symptoms (PCS) and disability following mTBI. In a historical comparison design, we compared two groups from independent randomized trials. The GET + UC group (N = 34) received GET (delivered over 16 videoconference sessions) in addition to usual care (UC). The historical comparison group (N = 71) received UC only. PCS severity (Rivermead Post Concussion Symptoms Questionnaire; RPQ) and disability (World Health Organization Disability Assessment Schedule; WHODAS 2.0 12-item) were measured at clinic intake (M = 2.7, SD = 1.1 months after injury) and again at M = 4.9 (SD = 1.1) months after injury. Between-group differences were estimated using linear mixed effects regression, with a sensitivity analysis controlling for injury-to-assessment intervals. The estimated average change on the RPQ was −14.3 in the GET + UC group and −5.3 in the UC group. The estimated average change on the WHODAS was −5.3 in the GET + UC group and −3.2 in the UC group. Between-group differences post-treatment were −5.3 on the RPQ and −1.5 on the WHODAS. Treatment effects were larger in sensitivity analyses. Findings suggest that a randomized controlled trial is warranted. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neuropsychological Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09602011.2024.2403647
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        Text: English
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      – SubjectFull: Exposure therapy
        Type: general
      – SubjectFull: Postconcussion syndrome
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      – SubjectFull: Avoidance (Psychology)
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      – SubjectFull: Brain injuries
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      – SubjectFull: Treatment effectiveness
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              Text: Aug2025
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