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Neuropsychological rehabilitation in patients with relapsing-remitting multiple sclerosis: a systematic review.

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Title: Neuropsychological rehabilitation in patients with relapsing-remitting multiple sclerosis: a systematic review.
Authors: Redero, Daniel (AUTHOR), Lázaro, Esther (AUTHOR), Vázquez, Natalia (AUTHOR), Soria, Cristina (AUTHOR)
Source: Applied Neuropsychology: Adult. Sep/Oct2025, Vol. 32 Issue 5, p1496-1504. 9p.
Subjects: Disease complications, Neurological disorders, Demyelination, Cognitive rehabilitation, Neuropsychological rehabilitation
Abstract: Introduction: Multiple sclerosis (MS) is an autoimmune, chronic, inflammatory and demyelinating disease that affects the Central Nervous System (CNS). It is the most common disabling neurological disease in young patients not caused by traumatic shock. Depending on how symptoms appear and how often they occur, there are different subtypes of MS. One of them is the relapsing-remitting phenotype (R-R), which the symptoms appear in the form of isolated outbreaks which, little by little, are causing the increase of the disease and its sequelae. MS encompasses a wide variety of symptoms, including possible cognitive impairment. In the literature there is no clear methodology and a defined and structured consensus to carry out neuropsychological rehabilitation processes in this group. Aim: This study aims to review and synthesize the available scientific evidence about the neuropsychological intervention on cognitive impairment of people with multiple sclerosis, relapsing-remitting subtype. Methods: Keywords for database search (Pubmed and Wos) were established, as well as inclusion and exclusion criteria. Then, the articles were selected according to inclusion and exclusion criteria; methodological quality criteria were applied. Articles published in the last 10 years were included. Results: Fifteen articles that met the established criteria were selected. Most of these studies identify as effective their cognitive rehabilitation programs, some of them showed changes in neural structures after rehabilitation. Discussion: It seems that cognitive rehabilitation is effective in influencing cognitive deterioration in R-R MS. This highlights the importance of neuropsychological evaluation and intervention from the early stages of the disease. [ABSTRACT FROM AUTHOR]
Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Neuropsychological rehabilitation in patients with relapsing-remitting multiple sclerosis: a systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Redero%2C+Daniel%22">Redero, Daniel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lázaro%2C+Esther%22">Lázaro, Esther</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vázquez%2C+Natalia%22">Vázquez, Natalia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soria%2C+Cristina%22">Soria, Cristina</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. Sep/Oct2025, Vol. 32 Issue 5, p1496-1504. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Demyelination%22">Demyelination</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+rehabilitation%22">Cognitive rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+rehabilitation%22">Neuropsychological rehabilitation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Multiple sclerosis (MS) is an autoimmune, chronic, inflammatory and demyelinating disease that affects the Central Nervous System (CNS). It is the most common disabling neurological disease in young patients not caused by traumatic shock. Depending on how symptoms appear and how often they occur, there are different subtypes of MS. One of them is the relapsing-remitting phenotype (R-R), which the symptoms appear in the form of isolated outbreaks which, little by little, are causing the increase of the disease and its sequelae. MS encompasses a wide variety of symptoms, including possible cognitive impairment. In the literature there is no clear methodology and a defined and structured consensus to carry out neuropsychological rehabilitation processes in this group. Aim: This study aims to review and synthesize the available scientific evidence about the neuropsychological intervention on cognitive impairment of people with multiple sclerosis, relapsing-remitting subtype. Methods: Keywords for database search (Pubmed and Wos) were established, as well as inclusion and exclusion criteria. Then, the articles were selected according to inclusion and exclusion criteria; methodological quality criteria were applied. Articles published in the last 10 years were included. Results: Fifteen articles that met the established criteria were selected. Most of these studies identify as effective their cognitive rehabilitation programs, some of them showed changes in neural structures after rehabilitation. Discussion: It seems that cognitive rehabilitation is effective in influencing cognitive deterioration in R-R MS. This highlights the importance of neuropsychological evaluation and intervention from the early stages of the disease. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186912359
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      – Type: doi
        Value: 10.1080/23279095.2023.2248642
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        Text: English
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        Type: general
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      – SubjectFull: Demyelination
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      – SubjectFull: Cognitive rehabilitation
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              M: 09
              Text: Sep/Oct2025
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              Y: 2025
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