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Size of the Cerebral Ventricular System in Patients Affected by Type 2 Diabetes Mellitus: A Retrospective Observational Study.

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Title: Size of the Cerebral Ventricular System in Patients Affected by Type 2 Diabetes Mellitus: A Retrospective Observational Study.
Authors: Currà, Antonio (AUTHOR), Corsini, Massimo (AUTHOR), Barchetta, Ilaria (AUTHOR), Cavallo, Maria Gisella (AUTHOR), Gargiulo, Patrizia (AUTHOR), Suppa, Marianna (AUTHOR), Peschillo, Simone (AUTHOR), Fattapposta, Francesco (AUTHOR), Trompetto, Carlo (AUTHOR), Mori, Laura (AUTHOR), Schenone, Cristina (AUTHOR), Missori, Paolo (AUTHOR), Colosimo, Carlo (AUTHOR)
Source: Acta Neurologica Scandinavica. 7/25/2025, Vol. 2025, p1-6. 6p.
Subjects: Type 2 diabetes, Cerebral ventricles, Comorbidity, Retrospective studies, Brain imaging, Platelet aggregation inhibitors, Age, Hydrocephalus
Abstract: Aim: This study is aimed at determining the prevalence of patients with Type 2 diabetes mellitus (T2DM) affected by abnormal ventricular enlargement (normal pressure hydrocephalus). Materials and Methods: Data were collected on diabetic patients from an outpatient diabetology clinic and nondiabetic patients who underwent brain CT or MRI, including sex, age, diabetes onset date, fasting blood glucose, HbA1c, Evans Index, and the time between diabetes diagnosis and neuroimaging. The metabolic profile was assessed by BMI, blood pressure, waist circumference, glomerular filtration rate, total cholesterol, LDL, HDL, and triglycerides. The use of ongoing therapies was recorded and categorized by drug class. Common comorbidities, such as ischemic heart disease, diabetic retinopathy, renal failure, and carotid atherosclerosis, were also documented. Results: Neuroradiological data were available for 272 diabetic patients (mean age: 71.6 ± 11.2 years) and 275 nondiabetic patients (mean age: 70.4 ± 12.5 years). Pathological ventricular enlargement was identified in 116 of 547 individuals (21%), with a higher prevalence among males (68%; p = 0.002). Ventricular enlargement was noted in 25% of diabetic patients and 17.1% of nondiabetic patients (p = 0.02). Diabetic patients with ventricular enlargement were significantly older (mean age: 76.9 years vs. 69.4 years) than those without enlargement (p = 0.01). The duration of diabetes was also significantly longer in patients with enlargement (mean: 16.5 years) compared to those without (p = 0.009). Age, male sex, longer diabetes duration, history of ischemic heart disease, beta‐blocker use, and antiplatelet therapy were significantly associated with a pathological Evans Index. In multivariate analysis, antiplatelet therapy was the strongest predictor of abnormal ventricular enlargement in T2DM patients after adjusting for confounding factors (p = 0.01). Conclusion: There is a high prevalence of pathological ventricular enlargement in patients with T2DM. Advanced age, male sex, longer disease duration, and the use of antiplatelet therapy are significantly associated with abnormal ventricular enlargement. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Size of the Cerebral Ventricular System in Patients Affected by Type 2 Diabetes Mellitus: A Retrospective Observational Study.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Currà%2C+Antonio%22">Currà, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Corsini%2C+Massimo%22">Corsini, Massimo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barchetta%2C+Ilaria%22">Barchetta, Ilaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavallo%2C+Maria+Gisella%22">Cavallo, Maria Gisella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gargiulo%2C+Patrizia%22">Gargiulo, Patrizia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suppa%2C+Marianna%22">Suppa, Marianna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peschillo%2C+Simone%22">Peschillo, Simone</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fattapposta%2C+Francesco%22">Fattapposta, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Trompetto%2C+Carlo%22">Trompetto, Carlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mori%2C+Laura%22">Mori, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schenone%2C+Cristina%22">Schenone, Cristina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Missori%2C+Paolo%22">Missori, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colosimo%2C+Carlo%22">Colosimo, Carlo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 7/25/2025, Vol. 2025, p1-6. 6p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Type+2+diabetes%22">Type 2 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+ventricles%22">Cerebral ventricles</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Platelet+aggregation+inhibitors%22">Platelet aggregation inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Age%22">Age</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocephalus%22">Hydrocephalus</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: This study is aimed at determining the prevalence of patients with Type 2 diabetes mellitus (T2DM) affected by abnormal ventricular enlargement (normal pressure hydrocephalus). Materials and Methods: Data were collected on diabetic patients from an outpatient diabetology clinic and nondiabetic patients who underwent brain CT or MRI, including sex, age, diabetes onset date, fasting blood glucose, HbA1c, Evans Index, and the time between diabetes diagnosis and neuroimaging. The metabolic profile was assessed by BMI, blood pressure, waist circumference, glomerular filtration rate, total cholesterol, LDL, HDL, and triglycerides. The use of ongoing therapies was recorded and categorized by drug class. Common comorbidities, such as ischemic heart disease, diabetic retinopathy, renal failure, and carotid atherosclerosis, were also documented. Results: Neuroradiological data were available for 272 diabetic patients (mean age: 71.6 ± 11.2 years) and 275 nondiabetic patients (mean age: 70.4 ± 12.5 years). Pathological ventricular enlargement was identified in 116 of 547 individuals (21%), with a higher prevalence among males (68%; p = 0.002). Ventricular enlargement was noted in 25% of diabetic patients and 17.1% of nondiabetic patients (p = 0.02). Diabetic patients with ventricular enlargement were significantly older (mean age: 76.9 years vs. 69.4 years) than those without enlargement (p = 0.01). The duration of diabetes was also significantly longer in patients with enlargement (mean: 16.5 years) compared to those without (p = 0.009). Age, male sex, longer diabetes duration, history of ischemic heart disease, beta‐blocker use, and antiplatelet therapy were significantly associated with a pathological Evans Index. In multivariate analysis, antiplatelet therapy was the strongest predictor of abnormal ventricular enlargement in T2DM patients after adjusting for confounding factors (p = 0.01). Conclusion: There is a high prevalence of pathological ventricular enlargement in patients with T2DM. Advanced age, male sex, longer disease duration, and the use of antiplatelet therapy are significantly associated with abnormal ventricular enlargement. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1155/ane/1231535
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1
    Subjects:
      – SubjectFull: Type 2 diabetes
        Type: general
      – SubjectFull: Cerebral ventricles
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Brain imaging
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      – SubjectFull: Platelet aggregation inhibitors
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      – SubjectFull: Age
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      – SubjectFull: Hydrocephalus
        Type: general
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              Text: 7/25/2025
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              Y: 2025
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