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Cholecystitis Treatment and Outcomes Among People Living With Dementia.

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Title: Cholecystitis Treatment and Outcomes Among People Living With Dementia.
Authors: Adler, Rachel R., Xiang, Lingwei, Shah, Samir K., Clark, Clancy J., Cooper, Zara, Hsu, John, Lipsitz, Stuart R., Weissman, Joel S., Finlayson, Emily
Source: Journal of the American Geriatrics Society. Jul2025, Vol. 73 Issue 7, p2088-2096. 9p.
Subjects: Patients, Patient readmissions, Hospital admission & discharge, Treatment effectiveness, Cholecystectomy, Retrospective studies, Minimally invasive procedures, Descriptive statistics, Odds ratio, Surgical complications, Medical records, Acquisition of data, Cholecystitis, Dementia patients, Regression analysis, Disease risk factors
Abstract: Background: Cholecystectomy is considered the definitive treatment option for cholecystitis, but the effect of different treatment options among people living with dementia (PLWD) has not been elucidated. This study compares outcomes following cholecystectomy, cholecystostomy tube, and medical management of cholecystitis among this high‐risk group. Methods: We conducted a retrospective analysis of Medicare claims data 1/1/2016 to 12/31/2020. The cohort comprised Medicare PLWD aged 66+ admitted to acute care facilities with a new primary diagnosis of cholecystitis. We used inverse propensity weighting regression to adjust for confounding by indication. We compared outcomes during index admission, readmissions, and mortality. Results: Eight thousand and seven hundred and seventy four individuals met inclusion criteria; 7% open cholecystectomy, 49% minimally invasive (MIS) cholecystectomy, 13% cholecystostomy tube, 31% managed medically. After adjustment, PLWD undergoing open or MIS cholecystectomy had a greater risk of intensive interventions (Open OR 3.3, p < 0.001; MIS OR 1.3, p = 0.02) and surgical complications (Open OR 10.6, p < 0.001; MIS OR 3.3, p < 0.001) during the index admission, but a lower risk of readmission (Open HR 0.9, p = 0.009; MIS HR 0.9, p < 0.001) and lower mortality (Open HR 0.6, p < 0.001; MIS 0.6, p < 0.001) compared with PLWD managed medically. PLWD managed with cholecystostomy tube had no difference in intensive interventions or surgical complications during the index admission, but a higher risk of readmission (HR 1.1, p = 0.01), cholecystectomy during readmission (HR 1.8, p < 0.001) and no difference in mortality compared to those managed medically. Conclusions: Over half of PLWD experiencing acute cholecystitis received definitive surgical treatment during the index admission. Open and MIS cholecystectomy were associated with worse outcomes during the index admission, but reduced mortality and readmissions in the 2 years following index admission. Cholecystostomy tube was associated with a greater likelihood of readmission and subsequent cholecystectomy, and no difference in mortality. These findings should be interpreted within the context of administrative data, which has the potential for selection bias and unmeasured confounding. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cholecystitis Treatment and Outcomes Among People Living With Dementia.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adler%2C+Rachel+R%2E%22&quot;&gt;Adler, Rachel R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiang%2C+Lingwei%22&quot;&gt;Xiang, Lingwei&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shah%2C+Samir+K%2E%22&quot;&gt;Shah, Samir K.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Clark%2C+Clancy+J%2E%22&quot;&gt;Clark, Clancy J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cooper%2C+Zara%22&quot;&gt;Cooper, Zara&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hsu%2C+John%22&quot;&gt;Hsu, John&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lipsitz%2C+Stuart+R%2E%22&quot;&gt;Lipsitz, Stuart R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Weissman%2C+Joel+S%2E%22&quot;&gt;Weissman, Joel S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Finlayson%2C+Emily%22&quot;&gt;Finlayson, Emily&lt;/searchLink&gt;
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  Data: Background: Cholecystectomy is considered the definitive treatment option for cholecystitis, but the effect of different treatment options among people living with dementia (PLWD) has not been elucidated. This study compares outcomes following cholecystectomy, cholecystostomy tube, and medical management of cholecystitis among this high‐risk group. Methods: We conducted a retrospective analysis of Medicare claims data 1/1/2016 to 12/31/2020. The cohort comprised Medicare PLWD aged 66+ admitted to acute care facilities with a new primary diagnosis of cholecystitis. We used inverse propensity weighting regression to adjust for confounding by indication. We compared outcomes during index admission, readmissions, and mortality. Results: Eight thousand and seven hundred and seventy four individuals met inclusion criteria; 7% open cholecystectomy, 49% minimally invasive (MIS) cholecystectomy, 13% cholecystostomy tube, 31% managed medically. After adjustment, PLWD undergoing open or MIS cholecystectomy had a greater risk of intensive interventions (Open OR 3.3, p &lt; 0.001; MIS OR 1.3, p = 0.02) and surgical complications (Open OR 10.6, p &lt; 0.001; MIS OR 3.3, p &lt; 0.001) during the index admission, but a lower risk of readmission (Open HR 0.9, p = 0.009; MIS HR 0.9, p &lt; 0.001) and lower mortality (Open HR 0.6, p &lt; 0.001; MIS 0.6, p &lt; 0.001) compared with PLWD managed medically. PLWD managed with cholecystostomy tube had no difference in intensive interventions or surgical complications during the index admission, but a higher risk of readmission (HR 1.1, p = 0.01), cholecystectomy during readmission (HR 1.8, p &lt; 0.001) and no difference in mortality compared to those managed medically. Conclusions: Over half of PLWD experiencing acute cholecystitis received definitive surgical treatment during the index admission. Open and MIS cholecystectomy were associated with worse outcomes during the index admission, but reduced mortality and readmissions in the 2 years following index admission. Cholecystostomy tube was associated with a greater likelihood of readmission and subsequent cholecystectomy, and no difference in mortality. These findings should be interpreted within the context of administrative data, which has the potential for selection bias and unmeasured confounding. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186990666
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jgs.19487
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 2088
    Subjects:
      – SubjectFull: Patients
        Type: general
      – SubjectFull: Patient readmissions
        Type: general
      – SubjectFull: Hospital admission & discharge
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Cholecystectomy
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Minimally invasive procedures
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Surgical complications
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Cholecystitis
        Type: general
      – SubjectFull: Dementia patients
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Disease risk factors
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      – TitleFull: Cholecystitis Treatment and Outcomes Among People Living With Dementia.
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            – D: 01
              M: 07
              Text: Jul2025
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