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Common salt (NaCl) causes developmental, behavioral, and physiological defects in Drosophila melanogaster.

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Title: Common salt (NaCl) causes developmental, behavioral, and physiological defects in Drosophila melanogaster.
Authors: Sahu, Swetapadma (AUTHOR), Dash, Kalpanarani (AUTHOR), Mishra, Monalisa (AUTHOR)
Source: Nutritional Neuroscience. Aug2025, Vol. 28 Issue 8, p891-909. 19p.
Subjects: Drosophila melanogaster, Salt, Free radicals, Physiology, Obesity, Pathological anatomy, DNA damage, Ecological assessment
Abstract: Purpose: The incidence of obesity has surged to pandemic levels in recent decades. Approximately 1.89 million obesity are linked to excessive salt consumption. This study aims to check the toxicity of salt at different concentrations using an invertebrate model organism Drosophila melanogaster. Methods: Drosophila food was mixed with different salt concentrations (50, 200, 400, 800 µM). The toxicity of salt in third instar larvae was checked via different experiments such as trypan blue assay, crawling assay, and other histological staining was done to check the deposition of lipid droplets and amount of reactive oxygen species. Food intake analysis was performed to check the feeding rate, and body weight was also calculated to check the obesity index. Several behavioral assays are also performed in adult flies. Results: Most significant abnormalities were seen at 50 and 200 µM concentrations. Feeding rate increased up to 60%, body weight was increased up to 12% in larvae, and 27% in adult at 200 µM concentration. Approximately 60% larvae and 58% adult flies had defective response to extreme heat. 28% larvae and 38% adult flies were not responding to cold temperature. 55% flies had a defective phototaxis behavior and 40% of them showed positive geotaxis at those range. Salt stress leads to the buildup of free radicals, resulting in DNA damage in both the gut and hemolymph. Findings: Most toxic consequences are observed at the lower concentration range as the feeding rate was higher. Flies show aversive response to feed on the higher concentration of salt. [ABSTRACT FROM AUTHOR]
Copyright of Nutritional Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Common salt (NaCl) causes developmental, behavioral, and physiological defects in Drosophila melanogaster.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Sahu%2C+Swetapadma%22">Sahu, Swetapadma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dash%2C+Kalpanarani%22">Dash, Kalpanarani</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mishra%2C+Monalisa%22">Mishra, Monalisa</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nutritional+Neuroscience%22">Nutritional Neuroscience</searchLink>. Aug2025, Vol. 28 Issue 8, p891-909. 19p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Drosophila+melanogaster%22">Drosophila melanogaster</searchLink><br /><searchLink fieldCode="DE" term="%22Salt%22">Salt</searchLink><br /><searchLink fieldCode="DE" term="%22Free+radicals%22">Free radicals</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Obesity%22">Obesity</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+anatomy%22">Pathological anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+damage%22">DNA damage</searchLink><br /><searchLink fieldCode="DE" term="%22Ecological+assessment%22">Ecological assessment</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: The incidence of obesity has surged to pandemic levels in recent decades. Approximately 1.89 million obesity are linked to excessive salt consumption. This study aims to check the toxicity of salt at different concentrations using an invertebrate model organism Drosophila melanogaster. Methods: Drosophila food was mixed with different salt concentrations (50, 200, 400, 800 µM). The toxicity of salt in third instar larvae was checked via different experiments such as trypan blue assay, crawling assay, and other histological staining was done to check the deposition of lipid droplets and amount of reactive oxygen species. Food intake analysis was performed to check the feeding rate, and body weight was also calculated to check the obesity index. Several behavioral assays are also performed in adult flies. Results: Most significant abnormalities were seen at 50 and 200 µM concentrations. Feeding rate increased up to 60%, body weight was increased up to 12% in larvae, and 27% in adult at 200 µM concentration. Approximately 60% larvae and 58% adult flies had defective response to extreme heat. 28% larvae and 38% adult flies were not responding to cold temperature. 55% flies had a defective phototaxis behavior and 40% of them showed positive geotaxis at those range. Salt stress leads to the buildup of free radicals, resulting in DNA damage in both the gut and hemolymph. Findings: Most toxic consequences are observed at the lower concentration range as the feeding rate was higher. Flies show aversive response to feed on the higher concentration of salt. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Nutritional Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/1028415X.2024.2441677
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Salt
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      – SubjectFull: Free radicals
        Type: general
      – SubjectFull: Physiology
        Type: general
      – SubjectFull: Obesity
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      – SubjectFull: Pathological anatomy
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      – SubjectFull: DNA damage
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      – SubjectFull: Ecological assessment
        Type: general
    Titles:
      – TitleFull: Common salt (NaCl) causes developmental, behavioral, and physiological defects in Drosophila melanogaster.
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            NameFull: Sahu, Swetapadma
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              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
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