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Autoimmune neuropsychiatric sequelae of group A streptococcal infections in Aboriginal and Torres Strait Islander people: an overlooked burden?

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Title: Autoimmune neuropsychiatric sequelae of group A streptococcal infections in Aboriginal and Torres Strait Islander people: an overlooked burden?
Authors: Ketheesan, Sarangan (AUTHOR), Wade, Vicki (AUTHOR), Hung, Te-Yu (AUTHOR), Roberts, Kathryn V (AUTHOR)
Source: Australasian Psychiatry. Aug2025, Vol. 33 Issue 4, p619-622. 4p.
Subjects: Pandas, Chorea, Streptococcus pyogenes, Cognition disorders, Neuropsychiatry, Indigenous peoples, Torres Strait Islanders, Autoimmunity
Abstract: Objective: We highlight two autoimmune neuropsychiatric sequelae of group A streptococcal (GAS) infection that may cause disproportionate levels of psychiatric morbidity in Aboriginal and Torres Strait Islander people: Sydenham's Chorea (SC) and Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). GAS infections, along with better characterised immune-mediated sequelae such as acute rheumatic fever and rheumatic heart disease, are highly prevalent in Aboriginal and Torres Strait Islander people, particularly in rural and remote communities, yet there is minimal information in the literature about the neuropsychiatric sequelae that might be expected. We suspect that there is an under-recognised burden of disease in these groups and seek to understand reasons for this. Conclusions: A multi-faceted, culturally attuned approach to better characterising and detecting the burden of these two conditions in Aboriginal and Torres Strait Islander people is required. Furthermore, larger scale clinical trials examining the efficacy of proposed treatments for SC and PANDAS are required to inform clinical guidelines. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Autoimmune neuropsychiatric sequelae of group A streptococcal infections in Aboriginal and Torres Strait Islander people: an overlooked burden?
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Ketheesan%2C+Sarangan%22">Ketheesan, Sarangan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wade%2C+Vicki%22">Wade, Vicki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hung%2C+Te-Yu%22">Hung, Te-Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roberts%2C+Kathryn+V%22">Roberts, Kathryn V</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Aug2025, Vol. 33 Issue 4, p619-622. 4p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pandas%22">Pandas</searchLink><br /><searchLink fieldCode="DE" term="%22Chorea%22">Chorea</searchLink><br /><searchLink fieldCode="DE" term="%22Streptococcus+pyogenes%22">Streptococcus pyogenes</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychiatry%22">Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Indigenous+peoples%22">Indigenous peoples</searchLink><br /><searchLink fieldCode="DE" term="%22Torres+Strait+Islanders%22">Torres Strait Islanders</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmunity%22">Autoimmunity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: We highlight two autoimmune neuropsychiatric sequelae of group A streptococcal (GAS) infection that may cause disproportionate levels of psychiatric morbidity in Aboriginal and Torres Strait Islander people: Sydenham's Chorea (SC) and Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). GAS infections, along with better characterised immune-mediated sequelae such as acute rheumatic fever and rheumatic heart disease, are highly prevalent in Aboriginal and Torres Strait Islander people, particularly in rural and remote communities, yet there is minimal information in the literature about the neuropsychiatric sequelae that might be expected. We suspect that there is an under-recognised burden of disease in these groups and seek to understand reasons for this. Conclusions: A multi-faceted, culturally attuned approach to better characterising and detecting the burden of these two conditions in Aboriginal and Torres Strait Islander people is required. Furthermore, larger scale clinical trials examining the efficacy of proposed treatments for SC and PANDAS are required to inform clinical guidelines. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1177/10398562251351462
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 619
    Subjects:
      – SubjectFull: Pandas
        Type: general
      – SubjectFull: Chorea
        Type: general
      – SubjectFull: Streptococcus pyogenes
        Type: general
      – SubjectFull: Cognition disorders
        Type: general
      – SubjectFull: Neuropsychiatry
        Type: general
      – SubjectFull: Indigenous peoples
        Type: general
      – SubjectFull: Torres Strait Islanders
        Type: general
      – SubjectFull: Autoimmunity
        Type: general
    Titles:
      – TitleFull: Autoimmune neuropsychiatric sequelae of group A streptococcal infections in Aboriginal and Torres Strait Islander people: an overlooked burden?
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            NameFull: Ketheesan, Sarangan
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            NameFull: Wade, Vicki
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            NameFull: Hung, Te-Yu
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            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
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