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Alpha-pine self-emulsifying nano formulation attenuates rotenone and trichloroethylene-induced dopaminergic loss.

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Title: Alpha-pine self-emulsifying nano formulation attenuates rotenone and trichloroethylene-induced dopaminergic loss.
Authors: Srivastava, Rajnish (AUTHOR), Choudhury, Pratim Kumar (AUTHOR), Dev, Suresh Kumar (AUTHOR), Rathore, Vaibhav (AUTHOR)
Source: International Journal of Neuroscience. Aug2025, Vol. 135 Issue 8, p938-955. 18p.
Subjects: Parkinson's disease, Oxidative stress, Treatment programs, Neurotoxic agents, Antioxidants, Pinene, Microemulsions, Dopaminergic neurons
Abstract: Aim: The current investigation's goals are to pharmacologically evaluate the neurotherapeutic role of the bioactive compound Alpha Pinene (ALP)-loaded Self-emulsifying nano-formulation (SENF) in neurotoxin (Rotenone and the Industrial Solvent Trichloroethylene)- induced dopaminergic loss. It is believed that these models simulate important aspects of the molecular pathogenesis of Parkinson's disease. Material and Methods: The ALP-nano-formulation's anti-Parkinson's activity was compared to ALP suspension in Wistar rats after rotenone and trichloro ethylene-induced dopaminergic loss. Neurobehavioral and motor performances were measured on the 14th, 21st, and 28th day in the rotenone model. However, in the trichloroethylene model, it was measured from the 4th to the 8th week. Results: Significant neurobehavioral improvement has been found in ALP-SENF treated animals then untreated and animals treated with plain ALP suspension. Furthermore, biochemical tests reveal marked expression of catalase, glutathione, and superoxide dismutase, which significantly combat the (Oxidative stress) OS-induced neurodegeneration. Conclusion: The antioxidant effect of ALP-SENF likely includes free radicals neutralization and the activation of enzymes associated with antioxidant activity, leading to the enhancement of neurobehavioral abnormalities caused by rotenone and trichloroethylene. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Alpha-pine self-emulsifying nano formulation attenuates rotenone and trichloroethylene-induced dopaminergic loss.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Srivastava%2C+Rajnish%22">Srivastava, Rajnish</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choudhury%2C+Pratim+Kumar%22">Choudhury, Pratim Kumar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dev%2C+Suresh+Kumar%22">Dev, Suresh Kumar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rathore%2C+Vaibhav%22">Rathore, Vaibhav</searchLink> (AUTHOR)
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Aug2025, Vol. 135 Issue 8, p938-955. 18p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+programs%22">Treatment programs</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotoxic+agents%22">Neurotoxic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Pinene%22">Pinene</searchLink><br /><searchLink fieldCode="DE" term="%22Microemulsions%22">Microemulsions</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: The current investigation's goals are to pharmacologically evaluate the neurotherapeutic role of the bioactive compound Alpha Pinene (ALP)-loaded Self-emulsifying nano-formulation (SENF) in neurotoxin (Rotenone and the Industrial Solvent Trichloroethylene)- induced dopaminergic loss. It is believed that these models simulate important aspects of the molecular pathogenesis of Parkinson's disease. Material and Methods: The ALP-nano-formulation's anti-Parkinson's activity was compared to ALP suspension in Wistar rats after rotenone and trichloro ethylene-induced dopaminergic loss. Neurobehavioral and motor performances were measured on the 14th, 21st, and 28th day in the rotenone model. However, in the trichloroethylene model, it was measured from the 4th to the 8th week. Results: Significant neurobehavioral improvement has been found in ALP-SENF treated animals then untreated and animals treated with plain ALP suspension. Furthermore, biochemical tests reveal marked expression of catalase, glutathione, and superoxide dismutase, which significantly combat the (Oxidative stress) OS-induced neurodegeneration. Conclusion: The antioxidant effect of ALP-SENF likely includes free radicals neutralization and the activation of enzymes associated with antioxidant activity, leading to the enhancement of neurobehavioral abnormalities caused by rotenone and trichloroethylene. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2024.2341916
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 938
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      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Treatment programs
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      – SubjectFull: Neurotoxic agents
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      – SubjectFull: Antioxidants
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      – SubjectFull: Pinene
        Type: general
      – SubjectFull: Microemulsions
        Type: general
      – SubjectFull: Dopaminergic neurons
        Type: general
    Titles:
      – TitleFull: Alpha-pine self-emulsifying nano formulation attenuates rotenone and trichloroethylene-induced dopaminergic loss.
        Type: main
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          Name:
            NameFull: Srivastava, Rajnish
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            NameFull: Choudhury, Pratim Kumar
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            NameFull: Dev, Suresh Kumar
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            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
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