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Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.

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Title: Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.
Authors: Shang, ZhaoXuan (AUTHOR), Fang, ChunQing (AUTHOR), Luo, GuoShuai (AUTHOR), Lang, XiaoE (AUTHOR), Zhang, Xiangyang (AUTHOR)
Source: Social Psychiatry & Psychiatric Epidemiology. Aug2025, Vol. 60 Issue 8, p1999-2012. 14p.
Subjects: Gender differences (Sociology), Adverse childhood experiences, Chinese people, Statistical correlation, Cognitive ability, Therapeutics, Symptoms, Schizophrenia
Abstract: Purpose: This study investigates the gender-specific associations between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia. Methods: A total of 601 patients with chronic schizophrenia were evaluated using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Positive and Negative Syndrome Scale (PANSS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation and regression analyses were performed to explore the relationships between childhood trauma and clinical symptoms and cognitive function, considering gender differences. Results: Childhood trauma prevalence showed no gender differences. In male patients, physical neglect predicted PANSS Positive symptoms (β = 0.123), and physical abuse was linked to lower Visuospatial Construction scores (β = −0.103). In female patients, emotional neglect predicted PANSS Positive (β = 0.225) and Excitement factors (β = 0.197), and emotional abuse predicted Depressive symptoms (β = 0.186). Sexual abuse was associated with lower language scores (β = −0.204), and physical neglect with deficits in Immediate (β = −0.261) and Delayed Memory (β = −0.157). Conclusion: The findings highlight distinct gender-specific patterns in the impact of childhood trauma on clinical symptoms among patients with chronic schizophrenia. This suggests the necessity for gender-specific therapeutic interventions to address these differences effectively. [ABSTRACT FROM AUTHOR]
Copyright of Social Psychiatry & Psychiatric Epidemiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Shang%2C+ZhaoXuan%22">Shang, ZhaoXuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+ChunQing%22">Fang, ChunQing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+GuoShuai%22">Luo, GuoShuai</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lang%2C+XiaoE%22">Lang, XiaoE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiangyang%22">Zhang, Xiangyang</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Social+Psychiatry+%26+Psychiatric+Epidemiology%22">Social Psychiatry & Psychiatric Epidemiology</searchLink>. Aug2025, Vol. 60 Issue 8, p1999-2012. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Gender+differences+%28Sociology%29%22">Gender differences (Sociology)</searchLink><br /><searchLink fieldCode="DE" term="%22Adverse+childhood+experiences%22">Adverse childhood experiences</searchLink><br /><searchLink fieldCode="DE" term="%22Chinese+people%22">Chinese people</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink>
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  Data: Purpose: This study investigates the gender-specific associations between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia. Methods: A total of 601 patients with chronic schizophrenia were evaluated using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Positive and Negative Syndrome Scale (PANSS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation and regression analyses were performed to explore the relationships between childhood trauma and clinical symptoms and cognitive function, considering gender differences. Results: Childhood trauma prevalence showed no gender differences. In male patients, physical neglect predicted PANSS Positive symptoms (β = 0.123), and physical abuse was linked to lower Visuospatial Construction scores (β = −0.103). In female patients, emotional neglect predicted PANSS Positive (β = 0.225) and Excitement factors (β = 0.197), and emotional abuse predicted Depressive symptoms (β = 0.186). Sexual abuse was associated with lower language scores (β = −0.204), and physical neglect with deficits in Immediate (β = −0.261) and Delayed Memory (β = −0.157). Conclusion: The findings highlight distinct gender-specific patterns in the impact of childhood trauma on clinical symptoms among patients with chronic schizophrenia. This suggests the necessity for gender-specific therapeutic interventions to address these differences effectively. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Social Psychiatry & Psychiatric Epidemiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00127-025-02826-2
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              Text: Aug2025
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