Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.

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Bibliographic Details
Title: Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.
Authors: Gilliot, Sixtine, Le Duc, Kévin, Chopinet, Caroline, Décaudin, Bertrand, Odou, Pascal, Storme, Laurent, Riadh Boukhris, Mohamed
Source: Pediatrics. Aug2025, Vol. 156 Issue 2, p1-5. 1p.
Subjects: Cesarean section, Congenital heart disease, Physical diagnosis, Pleural effusions, Catastrophic illness, Treatment effectiveness, Discharge planning, Enteral feeding, Intravenous therapy, Artificial respiration, Hydrops fetalis, Chylothorax, Phenylephrine
Abstract: There are few evidence-based treatment options for chylothorax in newborns. We report on 5 cases of preterm newborn infants who received drainage and continuous etilefrine infusion for clinically significant, refractory chylothorax. Irrespective of the cause of the effusion, etilefrine infusion was associated with a clear decrease in chylous output within 2 to 4 days of initiation with heart rates and blood pressures maintained within the age-normal limits. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:There are few evidence-based treatment options for chylothorax in newborns. We report on 5 cases of preterm newborn infants who received drainage and continuous etilefrine infusion for clinically significant, refractory chylothorax. Irrespective of the cause of the effusion, etilefrine infusion was associated with a clear decrease in chylous output within 2 to 4 days of initiation with heart rates and blood pressures maintained within the age-normal limits. [ABSTRACT FROM AUTHOR]
ISSN:00314005
DOI:10.1542/peds.2024-069683