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Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.

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Title: Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.
Authors: Gilliot, Sixtine, Le Duc, Kévin, Chopinet, Caroline, Décaudin, Bertrand, Odou, Pascal, Storme, Laurent, Riadh Boukhris, Mohamed
Source: Pediatrics. Aug2025, Vol. 156 Issue 2, p1-5. 1p.
Subjects: Cesarean section, Congenital heart disease, Physical diagnosis, Pleural effusions, Catastrophic illness, Treatment effectiveness, Discharge planning, Enteral feeding, Intravenous therapy, Artificial respiration, Hydrops fetalis, Chylothorax, Phenylephrine
Abstract: There are few evidence-based treatment options for chylothorax in newborns. We report on 5 cases of preterm newborn infants who received drainage and continuous etilefrine infusion for clinically significant, refractory chylothorax. Irrespective of the cause of the effusion, etilefrine infusion was associated with a clear decrease in chylous output within 2 to 4 days of initiation with heart rates and blood pressures maintained within the age-normal limits. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.
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  Data: <searchLink fieldCode="AR" term="%22Gilliot%2C+Sixtine%22">Gilliot, Sixtine</searchLink><br /><searchLink fieldCode="AR" term="%22Le+Duc%2C+Kévin%22">Le Duc, Kévin</searchLink><br /><searchLink fieldCode="AR" term="%22Chopinet%2C+Caroline%22">Chopinet, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Décaudin%2C+Bertrand%22">Décaudin, Bertrand</searchLink><br /><searchLink fieldCode="AR" term="%22Odou%2C+Pascal%22">Odou, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Storme%2C+Laurent%22">Storme, Laurent</searchLink><br /><searchLink fieldCode="AR" term="%22Riadh+Boukhris%2C+Mohamed%22">Riadh Boukhris, Mohamed</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Aug2025, Vol. 156 Issue 2, p1-5. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Cesarean+section%22">Cesarean section</searchLink><br /><searchLink fieldCode="DE" term="%22Congenital+heart+disease%22">Congenital heart disease</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+diagnosis%22">Physical diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Pleural+effusions%22">Pleural effusions</searchLink><br /><searchLink fieldCode="DE" term="%22Catastrophic+illness%22">Catastrophic illness</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Discharge+planning%22">Discharge planning</searchLink><br /><searchLink fieldCode="DE" term="%22Enteral+feeding%22">Enteral feeding</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+therapy%22">Intravenous therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+respiration%22">Artificial respiration</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrops+fetalis%22">Hydrops fetalis</searchLink><br /><searchLink fieldCode="DE" term="%22Chylothorax%22">Chylothorax</searchLink><br /><searchLink fieldCode="DE" term="%22Phenylephrine%22">Phenylephrine</searchLink>
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  Data: There are few evidence-based treatment options for chylothorax in newborns. We report on 5 cases of preterm newborn infants who received drainage and continuous etilefrine infusion for clinically significant, refractory chylothorax. Irrespective of the cause of the effusion, etilefrine infusion was associated with a clear decrease in chylous output within 2 to 4 days of initiation with heart rates and blood pressures maintained within the age-normal limits. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2024-069683
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      – Code: eng
        Text: English
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      – SubjectFull: Cesarean section
        Type: general
      – SubjectFull: Congenital heart disease
        Type: general
      – SubjectFull: Physical diagnosis
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      – SubjectFull: Pleural effusions
        Type: general
      – SubjectFull: Catastrophic illness
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Discharge planning
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      – SubjectFull: Enteral feeding
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Artificial respiration
        Type: general
      – SubjectFull: Hydrops fetalis
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      – SubjectFull: Chylothorax
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      – SubjectFull: Phenylephrine
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      – TitleFull: Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.
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            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
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