Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium.
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| Title: | Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium. |
|---|---|
| Authors: | Petkus, Andrew J. (AUTHOR), Reynolds, Chandra A. (AUTHOR), Catts, Vibeke S. (AUTHOR), Christensen, Kaare (AUTHOR), Finkel, Deborah (AUTHOR), Nygaard, Marianne (AUTHOR), Sachdev, Perminder S. (AUTHOR), Pedersen, Nancy L. (AUTHOR), Gatz, Margaret (AUTHOR) |
| Source: | Psychological Science (0956-7976). Aug2025, Vol. 36 Issue 8, p637-655. 19p. |
| Subjects: | Mental depression, Mortality risk factors, Gender differences (Sociology), Twin studies, Adults, Longitudinal method |
| Abstract: | In later older adulthood, individuals report increased depressive symptoms, whereas gender differences in depressive symptoms narrow. We evaluated whether terminal decline (i.e., accelerated worsening in proximity to death) explained these patterns. We examined the longitudinal trajectories of depressive symptoms in 2,411 participants (baseline age: 29–95 years) from the Interplay of Genes and Environments Across Multiple Studies consortium representing three countries (Sweden, Denmark, and Australia). Joint modeling revealed that individuals reporting larger annual increases in depressive symptoms after age 70 were at increased risk of death. Piecewise linear multilevel models with random changepoints revealed accelerated increases in depressive symptoms approximately 4 years before death. Co-twin control analyses with 98 twin pairs found that the deceased twin had significantly larger accelerations in depressive symptoms compared with the surviving twin. Men experienced more severe mortality-related increases compared with women. Terminal decline partially explains the increase in depressive symptoms in later older adulthood. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Science (0956-7976) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 187242749 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Petkus%2C+Andrew+J%2E%22">Petkus, Andrew J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reynolds%2C+Chandra+A%2E%22">Reynolds, Chandra A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Catts%2C+Vibeke+S%2E%22">Catts, Vibeke S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Christensen%2C+Kaare%22">Christensen, Kaare</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Finkel%2C+Deborah%22">Finkel, Deborah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nygaard%2C+Marianne%22">Nygaard, Marianne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sachdev%2C+Perminder+S%2E%22">Sachdev, Perminder S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Nancy+L%2E%22">Pedersen, Nancy L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gatz%2C+Margaret%22">Gatz, Margaret</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Science+%280956-7976%29%22">Psychological Science (0956-7976)</searchLink>. Aug2025, Vol. 36 Issue 8, p637-655. 19p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality+risk+factors%22">Mortality risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+differences+%28Sociology%29%22">Gender differences (Sociology)</searchLink><br /><searchLink fieldCode="DE" term="%22Twin+studies%22">Twin studies</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In later older adulthood, individuals report increased depressive symptoms, whereas gender differences in depressive symptoms narrow. We evaluated whether terminal decline (i.e., accelerated worsening in proximity to death) explained these patterns. We examined the longitudinal trajectories of depressive symptoms in 2,411 participants (baseline age: 29–95 years) from the Interplay of Genes and Environments Across Multiple Studies consortium representing three countries (Sweden, Denmark, and Australia). Joint modeling revealed that individuals reporting larger annual increases in depressive symptoms after age 70 were at increased risk of death. Piecewise linear multilevel models with random changepoints revealed accelerated increases in depressive symptoms approximately 4 years before death. Co-twin control analyses with 98 twin pairs found that the deceased twin had significantly larger accelerations in depressive symptoms compared with the surviving twin. Men experienced more severe mortality-related increases compared with women. Terminal decline partially explains the increase in depressive symptoms in later older adulthood. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Science (0956-7976) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/09567976251351022 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 637 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Mortality risk factors Type: general – SubjectFull: Gender differences (Sociology) Type: general – SubjectFull: Twin studies Type: general – SubjectFull: Adults Type: general – SubjectFull: Longitudinal method Type: general Titles: – TitleFull: Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Petkus, Andrew J. – PersonEntity: Name: NameFull: Reynolds, Chandra A. – PersonEntity: Name: NameFull: Catts, Vibeke S. – PersonEntity: Name: NameFull: Christensen, Kaare – PersonEntity: Name: NameFull: Finkel, Deborah – PersonEntity: Name: NameFull: Nygaard, Marianne – PersonEntity: Name: NameFull: Sachdev, Perminder S. – PersonEntity: Name: NameFull: Pedersen, Nancy L. – PersonEntity: Name: NameFull: Gatz, Margaret IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09567976 Numbering: – Type: volume Value: 36 – Type: issue Value: 8 Titles: – TitleFull: Psychological Science (0956-7976) Type: main |
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