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Transfer of Motor and Perceptual Learning in Parkinson's Disease.

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Title: Transfer of Motor and Perceptual Learning in Parkinson's Disease.
Authors: Ueda, Naohisa (AUTHOR), Hayashi, Noriko (AUTHOR), Higashiyama, Yuichi (AUTHOR), Miyaji, Yosuke (AUTHOR), Kimura, Katsuo (AUTHOR), Joki, Hideto (AUTHOR), Kishida, Hitaru (AUTHOR), Takeuchi, Hideyuki (AUTHOR), Koyano, Shigeru (AUTHOR), Doi, Hiroshi (AUTHOR), Tanaka, Fumiaki (AUTHOR), Trojano, Luigi (AUTHOR)
Source: Acta Neurologica Scandinavica. 8/15/2025, p1-15. 15p.
Subjects: Parkinson's disease, Motor learning, Transfer of training, Perceptual learning, Neural circuitry, Parietal lobe, Cognitive ability
Abstract: Introduction: Patients with Parkinson's disease (PD) show impairments of motor and perceptual learning; however, their abilities to apply and generalize skills learned in one condition to new situations (learning transfer) remain unclear. Herein, we investigated motor and perceptual learning transfer abilities and their underlying neural substrates in patients with PD. Materials and Methods: Forty‐four patients with PD and 42 healthy controls (NCs) were investigated. Motor learning transfer ability (MLTA) and perceptual learning transfer ability (PLTA) were assessed immediately after learning (i.e., in the early phase) and were defined, respectively, as the ability to adapt to angle changes in a reaching task with rotation perturbation and to adapt to domain changes during a categorization task. Additionally, late‐phase retention of motor learning and transfer performance were evaluated the day after the early‐phase assessment. Results: MLTA and PLTA in the early phase, as well as retention and transfer performance of motor learning in the late phase, were more impaired in patients with PD than in NCs. In the early phase, the MLTA score was significantly positively correlated with the PLTA score and the number of categories correctly answered in the Modified Card Sorting Test (MCSTcategories) in patients with PD. In the late phase, the transfer performance of motor learning was significantly positively associated with the degree of motor learning retention. The MLTA score, PLTA score, and MCSTcategories value were all positively correlated with blood flow in the right inferior parietal lobule (IPL). Discussion: Dysfunction of the right IPL region in patients with PD may be associated with impairments in early‐phase motor and perceptual learning transfer, as well as poor MCST performance. Furthermore, late‐phase motor learning transfer performance may depend on long‐term (24 h) motor learning retention. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Transfer of Motor and Perceptual Learning in Parkinson's Disease.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Ueda%2C+Naohisa%22">Ueda, Naohisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hayashi%2C+Noriko%22">Hayashi, Noriko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Higashiyama%2C+Yuichi%22">Higashiyama, Yuichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miyaji%2C+Yosuke%22">Miyaji, Yosuke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kimura%2C+Katsuo%22">Kimura, Katsuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Joki%2C+Hideto%22">Joki, Hideto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kishida%2C+Hitaru%22">Kishida, Hitaru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takeuchi%2C+Hideyuki%22">Takeuchi, Hideyuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koyano%2C+Shigeru%22">Koyano, Shigeru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doi%2C+Hiroshi%22">Doi, Hiroshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tanaka%2C+Fumiaki%22">Tanaka, Fumiaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Trojano%2C+Luigi%22">Trojano, Luigi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 8/15/2025, p1-15. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+learning%22">Motor learning</searchLink><br /><searchLink fieldCode="DE" term="%22Transfer+of+training%22">Transfer of training</searchLink><br /><searchLink fieldCode="DE" term="%22Perceptual+learning%22">Perceptual learning</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink><br /><searchLink fieldCode="DE" term="%22Parietal+lobe%22">Parietal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Patients with Parkinson's disease (PD) show impairments of motor and perceptual learning; however, their abilities to apply and generalize skills learned in one condition to new situations (learning transfer) remain unclear. Herein, we investigated motor and perceptual learning transfer abilities and their underlying neural substrates in patients with PD. Materials and Methods: Forty‐four patients with PD and 42 healthy controls (NCs) were investigated. Motor learning transfer ability (MLTA) and perceptual learning transfer ability (PLTA) were assessed immediately after learning (i.e., in the early phase) and were defined, respectively, as the ability to adapt to angle changes in a reaching task with rotation perturbation and to adapt to domain changes during a categorization task. Additionally, late‐phase retention of motor learning and transfer performance were evaluated the day after the early‐phase assessment. Results: MLTA and PLTA in the early phase, as well as retention and transfer performance of motor learning in the late phase, were more impaired in patients with PD than in NCs. In the early phase, the MLTA score was significantly positively correlated with the PLTA score and the number of categories correctly answered in the Modified Card Sorting Test (MCSTcategories) in patients with PD. In the late phase, the transfer performance of motor learning was significantly positively associated with the degree of motor learning retention. The MLTA score, PLTA score, and MCSTcategories value were all positively correlated with blood flow in the right inferior parietal lobule (IPL). Discussion: Dysfunction of the right IPL region in patients with PD may be associated with impairments in early‐phase motor and perceptual learning transfer, as well as poor MCST performance. Furthermore, late‐phase motor learning transfer performance may depend on long‐term (24 h) motor learning retention. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=187347444
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      – Type: doi
        Value: 10.1155/ane/2203350
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 1
    Subjects:
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Motor learning
        Type: general
      – SubjectFull: Transfer of training
        Type: general
      – SubjectFull: Perceptual learning
        Type: general
      – SubjectFull: Neural circuitry
        Type: general
      – SubjectFull: Parietal lobe
        Type: general
      – SubjectFull: Cognitive ability
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    Titles:
      – TitleFull: Transfer of Motor and Perceptual Learning in Parkinson's Disease.
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              Text: 8/15/2025
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              Y: 2025
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