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Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder.

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Title: Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder.
Authors: Erickson, Craig A., Shaffer, Rebecca C., Will, Meredith, Schmitt, Lauren M., Horn, Paul, Hirst, Kathy, Pedapati, Ernest V., Ober, Nicole, Tumuluru, Rameshwari V., Handen, Benjamin L., Beversdorf, David Q.
Source: Journal of Autism & Developmental Disorders. Sep2025, Vol. 55 Issue 9, p3387-3394. 8p.
Subjects: Anti-inflammatory agents, Tetracycline, Research funding, Autism, Statistical sampling, Blind experiment, Treatment effectiveness, Randomized controlled trials, Neuroinflammation, Descriptive statistics, Crossover trials, Caregivers, Matrix metalloproteinases, Asperger's syndrome, Minocycline, Data analysis software, Drug tolerance
Abstract: Neuroinflammatory mechanisms have been implicated in the pathophysiology of autism spectrum disorder (ASD). Minocycline is a matrix metalloproteinase inhibitor 9 (MMP9) inhibitor tetracycline antibiotic with known anti-inflammatory properties. In preclinical animal models of ASD, minocycline has demonstrated potential positive effects on phenotypes that may have relevance to ASD. We conducted the first placebo-controlled study of minocycline in ASD. This double-blind, placebo-controlled crossover trial employed four week treatment periods with a two week washout period. Twenty-four 12–22 year olds (mean age 17.4 years; range 12.9–22.5 years) with ASD were enrolled. Overall minocycline was well tolerated. No minocycline-associated clinical changes were noted with treatment on any performance or clinician or caregiver completed measures were noted. We hypothesize that either minocycline does not have potential therapeutic effects in ASD or our project was underpowered to define potential subject subgroups who may potentially respond positively to this drug. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder.
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  Data: <searchLink fieldCode="AR" term="%22Erickson%2C+Craig+A%2E%22">Erickson, Craig A.</searchLink><br /><searchLink fieldCode="AR" term="%22Shaffer%2C+Rebecca+C%2E%22">Shaffer, Rebecca C.</searchLink><br /><searchLink fieldCode="AR" term="%22Will%2C+Meredith%22">Will, Meredith</searchLink><br /><searchLink fieldCode="AR" term="%22Schmitt%2C+Lauren+M%2E%22">Schmitt, Lauren M.</searchLink><br /><searchLink fieldCode="AR" term="%22Horn%2C+Paul%22">Horn, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Hirst%2C+Kathy%22">Hirst, Kathy</searchLink><br /><searchLink fieldCode="AR" term="%22Pedapati%2C+Ernest+V%2E%22">Pedapati, Ernest V.</searchLink><br /><searchLink fieldCode="AR" term="%22Ober%2C+Nicole%22">Ober, Nicole</searchLink><br /><searchLink fieldCode="AR" term="%22Tumuluru%2C+Rameshwari+V%2E%22">Tumuluru, Rameshwari V.</searchLink><br /><searchLink fieldCode="AR" term="%22Handen%2C+Benjamin+L%2E%22">Handen, Benjamin L.</searchLink><br /><searchLink fieldCode="AR" term="%22Beversdorf%2C+David+Q%2E%22">Beversdorf, David Q.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Sep2025, Vol. 55 Issue 9, p3387-3394. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Tetracycline%22">Tetracycline</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Blind+experiment%22">Blind experiment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroinflammation%22">Neuroinflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Crossover+trials%22">Crossover trials</searchLink><br /><searchLink fieldCode="DE" term="%22Caregivers%22">Caregivers</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+metalloproteinases%22">Matrix metalloproteinases</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Minocycline%22">Minocycline</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+tolerance%22">Drug tolerance</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Neuroinflammatory mechanisms have been implicated in the pathophysiology of autism spectrum disorder (ASD). Minocycline is a matrix metalloproteinase inhibitor 9 (MMP9) inhibitor tetracycline antibiotic with known anti-inflammatory properties. In preclinical animal models of ASD, minocycline has demonstrated potential positive effects on phenotypes that may have relevance to ASD. We conducted the first placebo-controlled study of minocycline in ASD. This double-blind, placebo-controlled crossover trial employed four week treatment periods with a two week washout period. Twenty-four 12–22 year olds (mean age 17.4 years; range 12.9–22.5 years) with ASD were enrolled. Overall minocycline was well tolerated. No minocycline-associated clinical changes were noted with treatment on any performance or clinician or caregiver completed measures were noted. We hypothesize that either minocycline does not have potential therapeutic effects in ASD or our project was underpowered to define potential subject subgroups who may potentially respond positively to this drug. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10803-023-06132-1
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      – Code: eng
        Text: English
    PhysicalDescription:
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        PageCount: 8
        StartPage: 3387
    Subjects:
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Tetracycline
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Statistical sampling
        Type: general
      – SubjectFull: Blind experiment
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Neuroinflammation
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Crossover trials
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      – SubjectFull: Caregivers
        Type: general
      – SubjectFull: Matrix metalloproteinases
        Type: general
      – SubjectFull: Asperger's syndrome
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      – SubjectFull: Minocycline
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      – SubjectFull: Data analysis software
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      – SubjectFull: Drug tolerance
        Type: general
    Titles:
      – TitleFull: Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder.
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              Text: Sep2025
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