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"Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".

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Title: "Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".
Authors: Lombardi, Gemma (AUTHOR), Bagnoli, Silvia (AUTHOR), Ingannato, Assunta (AUTHOR), Finocchi, Alice (AUTHOR), Campagnini, Silvia (AUTHOR), Fostinelli, Silvia (AUTHOR), Longobardi, Antonio (AUTHOR), Ghidoni, Roberta (AUTHOR), Binetti, Giuliano (AUTHOR), Borroni, Barbara (AUTHOR), Rivolta, Jasmine (AUTHOR), Padiglioni, Sonia (AUTHOR), Bessi, Valentina (AUTHOR), Sorbi, Sandro (AUTHOR), Nacmias, Benedetta (AUTHOR)
Source: Neurological Sciences. Sep2025, Vol. 46 Issue 9, p4349-4359. 11p.
Subjects: Frontotemporal dementia, Italian language, Methylation, Pyrosequencing, Disease progression
Abstract: Introduction: Little is known regarding the relationship between methylation levels and Frontotemporal Dementia (FTD). Objective: The objective of the present study was to assess the relationship between blood MAPT methylation levels and clinical expression in FTD. Methods: This cross-sectional observational study was conducted including 54 Italian patients with different phenotypes: 22 behavioral variant FTD (bvFTD), 10 semantic variant (svPPA), 22 non-fluent variant (nfv) Primary Progressive Aphasia (PPA). Results: Results reveal a negative correlation between MAPT methylation levels determined by pyrosequencing analysis and the severity of disease in the FTD group and highlight an association between nfvPPA variant and intermediate-high levels of MAPT methylation, which persists also considering disease severity. Conclusions: Our findings allow us to speculate that the degree of MAPT methylation in the blood, a test minimally invasive, cost-effective, and easily repeatable could be useful to differentiate FTD variants at onset and to confirm disease stage in symptomatic FTD patients. Further studies, also with a longitudinal design, are warranted to confirm our results. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: "Assessing relationship between blood MAPT methylation levels and clinical expression in Frontotemporal Dementia".
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  Data: <searchLink fieldCode="AR" term="%22Lombardi%2C+Gemma%22">Lombardi, Gemma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bagnoli%2C+Silvia%22">Bagnoli, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ingannato%2C+Assunta%22">Ingannato, Assunta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Finocchi%2C+Alice%22">Finocchi, Alice</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campagnini%2C+Silvia%22">Campagnini, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fostinelli%2C+Silvia%22">Fostinelli, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Longobardi%2C+Antonio%22">Longobardi, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghidoni%2C+Roberta%22">Ghidoni, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Binetti%2C+Giuliano%22">Binetti, Giuliano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Borroni%2C+Barbara%22">Borroni, Barbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rivolta%2C+Jasmine%22">Rivolta, Jasmine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Padiglioni%2C+Sonia%22">Padiglioni, Sonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bessi%2C+Valentina%22">Bessi, Valentina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sorbi%2C+Sandro%22">Sorbi, Sandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nacmias%2C+Benedetta%22">Nacmias, Benedetta</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Frontotemporal+dementia%22">Frontotemporal dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Italian+language%22">Italian language</searchLink><br /><searchLink fieldCode="DE" term="%22Methylation%22">Methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Pyrosequencing%22">Pyrosequencing</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink>
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  Data: Introduction: Little is known regarding the relationship between methylation levels and Frontotemporal Dementia (FTD). Objective: The objective of the present study was to assess the relationship between blood MAPT methylation levels and clinical expression in FTD. Methods: This cross-sectional observational study was conducted including 54 Italian patients with different phenotypes: 22 behavioral variant FTD (bvFTD), 10 semantic variant (svPPA), 22 non-fluent variant (nfv) Primary Progressive Aphasia (PPA). Results: Results reveal a negative correlation between MAPT methylation levels determined by pyrosequencing analysis and the severity of disease in the FTD group and highlight an association between nfvPPA variant and intermediate-high levels of MAPT methylation, which persists also considering disease severity. Conclusions: Our findings allow us to speculate that the degree of MAPT methylation in the blood, a test minimally invasive, cost-effective, and easily repeatable could be useful to differentiate FTD variants at onset and to confirm disease stage in symptomatic FTD patients. Further studies, also with a longitudinal design, are warranted to confirm our results. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Methylation
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