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Clinical value of serum LINC02446 and S100B in early diagnosis and prognosis assessment of traumatic brain injury.

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Title: Clinical value of serum LINC02446 and S100B in early diagnosis and prognosis assessment of traumatic brain injury.
Authors: Ma, Rong (AUTHOR), Liu, Yu (AUTHOR), Mao, Qing (AUTHOR)
Source: International Journal of Neuroscience. Sep2025, Vol. 135 Issue 9, p998-1005. 8p.
Subjects: Diagnosis, Prognosis, Biomarkers, Blood sampling, LincRNA, Brain injuries, Receiver operating characteristic curves
Abstract: Objective: To detect the expression levels of LINC02446 and S100B in serum of patients with traumatic brain injury (TBI) and explore their values as diagnostic and prognostic indicators for TBI. Method: Abnormal expressed RNAs in brain injury were screened from the dataset GSE1131475. Serums were collected from moderate to severe TBI patients at 1–3 and 4–12 h post injury. Quantitative polymerase chain reaction was used to detect the expression levels of LINC02446 and S100B in serum. The Glasgow Outcome Scale was used for prognostic evaluation. The diagnostic and prognostic efficacy of LINC02446 and S100B in TBI was evaluated using the receiver operating characteristic (ROC) curve. Result: The serum expression levels of LINC02446 and S100B in the TBI group were significantly increased. The expression levels of LINC02446 and S100B in the severe TBI group were significantly higher than those in the mild TBI group. ROC curve analysis showed that the combination of LINC02446 and S100B can distinguish TBI patients from healthy controls, as well as mild TBI from moderate to severe TBI. At the 6-month follow-up, the expression levels of LINC02446 and S100B in TBI patients with poor prognosis were significantly higher than those in patients with good prognosis, and ROC results showed their differentiation value. Moreover, the expression level of LINC02446 at 0–3 h can serve as an independent prognostic factor for poor prognosis. Conclusion: Serum LINC02446 and S100B hold clinical application value in the diagnosis and prognosis of TBI and are expected to become new potential biomarkers. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Clinical value of serum LINC02446 and S100B in early diagnosis and prognosis assessment of traumatic brain injury.
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  Data: <searchLink fieldCode="AR" term="%22Ma%2C+Rong%22">Ma, Rong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yu%22">Liu, Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mao%2C+Qing%22">Mao, Qing</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Sep2025, Vol. 135 Issue 9, p998-1005. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sampling%22">Blood sampling</searchLink><br /><searchLink fieldCode="DE" term="%22LincRNA%22">LincRNA</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Receiver+operating+characteristic+curves%22">Receiver operating characteristic curves</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: To detect the expression levels of LINC02446 and S100B in serum of patients with traumatic brain injury (TBI) and explore their values as diagnostic and prognostic indicators for TBI. Method: Abnormal expressed RNAs in brain injury were screened from the dataset GSE1131475. Serums were collected from moderate to severe TBI patients at 1–3 and 4–12 h post injury. Quantitative polymerase chain reaction was used to detect the expression levels of LINC02446 and S100B in serum. The Glasgow Outcome Scale was used for prognostic evaluation. The diagnostic and prognostic efficacy of LINC02446 and S100B in TBI was evaluated using the receiver operating characteristic (ROC) curve. Result: The serum expression levels of LINC02446 and S100B in the TBI group were significantly increased. The expression levels of LINC02446 and S100B in the severe TBI group were significantly higher than those in the mild TBI group. ROC curve analysis showed that the combination of LINC02446 and S100B can distinguish TBI patients from healthy controls, as well as mild TBI from moderate to severe TBI. At the 6-month follow-up, the expression levels of LINC02446 and S100B in TBI patients with poor prognosis were significantly higher than those in patients with good prognosis, and ROC results showed their differentiation value. Moreover, the expression level of LINC02446 at 0–3 h can serve as an independent prognostic factor for poor prognosis. Conclusion: Serum LINC02446 and S100B hold clinical application value in the diagnosis and prognosis of TBI and are expected to become new potential biomarkers. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/00207454.2024.2341929
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Prognosis
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      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Blood sampling
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      – SubjectFull: LincRNA
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      – SubjectFull: Brain injuries
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      – SubjectFull: Receiver operating characteristic curves
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      – TitleFull: Clinical value of serum LINC02446 and S100B in early diagnosis and prognosis assessment of traumatic brain injury.
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            NameFull: Ma, Rong
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            – D: 01
              M: 09
              Text: Sep2025
              Type: published
              Y: 2025
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