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Cardiovascular, kidney, and metabolic health: an actionable vision for heart failure prevention.

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Title: Cardiovascular, kidney, and metabolic health: an actionable vision for heart failure prevention.
Authors: Ostrominski, John W (AUTHOR), Cheng, Alice Y Y (AUTHOR), Nelson, Adam J (AUTHOR), Neuen, Brendon L (AUTHOR), Sattar, Naveed (AUTHOR), Tuttle, Katherine R (AUTHOR), Vaduganathan, Muthiah (AUTHOR)
Source: Lancet. Sep2025, Vol. 406 Issue 10508, p1171-1192. 22p.
Subjects: Cardiovascular diseases, Kidney diseases, Drug therapy, Epidemiology, Health care industry, Preventive medicine, Metabolic disorders, Molecular pathology
Abstract: The substantial and growing prevalence of heart failure, which remains the leading cause of preventable hospitalisation worldwide, has brought heart failure prevention into sharp focus. Although this condition has historically been characterised by impaired cardiac function, mounting evidence has underscored its complex and multisystem pathobiology. Epidemiological studies have indicated that other forms of cardiovascular disease, along with kidney and metabolic dysfunction, frequently and increasingly contribute to heart failure onset. Clinical trials have additionally demonstrated the power of several new pharmacotherapies to simultaneously modify cardiovascular, kidney, and metabolic (CKM) health. This convergence of epidemiology and therapy highlights deeply interconnected mechanisms of disease, identifying CKM diseases—and their pathophysiological and sociostructural antecedents—as important but often under-recognised targets for heart failure prevention. Herein, we illustrate that positioning heart failure prevention within the broader context of CKM health provides an actionable framework for patients, health-care professionals, health systems, communities, and policy makers. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cardiovascular, kidney, and metabolic health: an actionable vision for heart failure prevention.
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  Data: <searchLink fieldCode="AR" term="%22Ostrominski%2C+John+W%22">Ostrominski, John W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Alice+Y+Y%22">Cheng, Alice Y Y</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nelson%2C+Adam+J%22">Nelson, Adam J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neuen%2C+Brendon+L%22">Neuen, Brendon L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sattar%2C+Naveed%22">Sattar, Naveed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tuttle%2C+Katherine+R%22">Tuttle, Katherine R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vaduganathan%2C+Muthiah%22">Vaduganathan, Muthiah</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. Sep2025, Vol. 406 Issue 10508, p1171-1192. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+diseases%22">Kidney diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+therapy%22">Drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Health+care+industry%22">Health care industry</searchLink><br /><searchLink fieldCode="DE" term="%22Preventive+medicine%22">Preventive medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+disorders%22">Metabolic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+pathology%22">Molecular pathology</searchLink>
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  Data: The substantial and growing prevalence of heart failure, which remains the leading cause of preventable hospitalisation worldwide, has brought heart failure prevention into sharp focus. Although this condition has historically been characterised by impaired cardiac function, mounting evidence has underscored its complex and multisystem pathobiology. Epidemiological studies have indicated that other forms of cardiovascular disease, along with kidney and metabolic dysfunction, frequently and increasingly contribute to heart failure onset. Clinical trials have additionally demonstrated the power of several new pharmacotherapies to simultaneously modify cardiovascular, kidney, and metabolic (CKM) health. This convergence of epidemiology and therapy highlights deeply interconnected mechanisms of disease, identifying CKM diseases—and their pathophysiological and sociostructural antecedents—as important but often under-recognised targets for heart failure prevention. Herein, we illustrate that positioning heart failure prevention within the broader context of CKM health provides an actionable framework for patients, health-care professionals, health systems, communities, and policy makers. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=187893559
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        Value: 10.1016/S0140-6736(25)01384-4
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        Text: English
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      – SubjectFull: Metabolic disorders
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              Text: Sep2025
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