A literature review exploring whether meaningful change threshold estimates for patient-reported outcome (PRO) measures vary depending on baseline severity.
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| Title: | A literature review exploring whether meaningful change threshold estimates for patient-reported outcome (PRO) measures vary depending on baseline severity. |
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| Authors: | Sims, Joel (AUTHOR), Trigg, Andrew (AUTHOR), Flynn, Jessica (AUTHOR), Lydon, Aoife (AUTHOR), Griffiths, Natasha (AUTHOR), Cocks, Kim (AUTHOR), Arbuckle, Rob (AUTHOR) |
| Source: | Quality of Life Research. Sep2025, Vol. 34 Issue 9, p2489-2499. 11p. |
| Subjects: | Patient reported outcome measures, Severity of illness index, Health outcome assessment, Statistical bias, Scholarly peer review, Clinical trials |
| Abstract: | Purpose: Meaningful change thresholds for patient-reported outcome (PRO) measures may differ according to patients' baseline disease severity. This review aimed to explore methods used in the peer-reviewed literature to assess the relationship between baseline severity and meaningful change thresholds and the nature of this relationship. Methods: A structured literature review was conducted to identify relevant abstracts published between 2018–2022 reporting estimation of PRO meaningful change thresholds by baseline disease severity. Methods to estimate thresholds and direction of the relationship with baseline severity were extracted. Results: 1029 abstracts were screened and 22 full-text articles were deemed eligible for inclusion in the review. All 22 articles reported meaningful change thresholds that were estimated by baseline severity. Nearly all studies (n = 21) used anchor-based methods and reported thresholds for improvement. Most studies (n = 19) used the baseline score of the PRO being examined to define baseline severity. Baseline severity dependency was often tested by repeating methods within baseline-stratified groups (n = 16). All studies reported at least one PRO score where meaningful change was dependent upon baseline severity. The direction of the relationship for improvement was predominately a larger meaningful change threshold for worse baseline severity (n = 21). Conclusion: Methods used to assess baseline severity dependency for meaningful change thresholds vary, however most studies reviewed concluded that larger thresholds are warranted for worse baseline severity. Future work should explore how to distinguish true baseline severity dependency from statistical artifacts to ensure accurate interpretation of PROs in both clinical trials and clinical practice. [ABSTRACT FROM AUTHOR] |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 187972851 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A literature review exploring whether meaningful change threshold estimates for patient-reported outcome (PRO) measures vary depending on baseline severity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sims%2C+Joel%22">Sims, Joel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Trigg%2C+Andrew%22">Trigg, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flynn%2C+Jessica%22">Flynn, Jessica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lydon%2C+Aoife%22">Lydon, Aoife</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Griffiths%2C+Natasha%22">Griffiths, Natasha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cocks%2C+Kim%22">Cocks, Kim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arbuckle%2C+Rob%22">Arbuckle, Rob</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Sep2025, Vol. 34 Issue 9, p2489-2499. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Patient+reported+outcome+measures%22">Patient reported outcome measures</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+bias%22">Statistical bias</searchLink><br /><searchLink fieldCode="DE" term="%22Scholarly+peer+review%22">Scholarly peer review</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Meaningful change thresholds for patient-reported outcome (PRO) measures may differ according to patients' baseline disease severity. This review aimed to explore methods used in the peer-reviewed literature to assess the relationship between baseline severity and meaningful change thresholds and the nature of this relationship. Methods: A structured literature review was conducted to identify relevant abstracts published between 2018–2022 reporting estimation of PRO meaningful change thresholds by baseline disease severity. Methods to estimate thresholds and direction of the relationship with baseline severity were extracted. Results: 1029 abstracts were screened and 22 full-text articles were deemed eligible for inclusion in the review. All 22 articles reported meaningful change thresholds that were estimated by baseline severity. Nearly all studies (n = 21) used anchor-based methods and reported thresholds for improvement. Most studies (n = 19) used the baseline score of the PRO being examined to define baseline severity. Baseline severity dependency was often tested by repeating methods within baseline-stratified groups (n = 16). All studies reported at least one PRO score where meaningful change was dependent upon baseline severity. The direction of the relationship for improvement was predominately a larger meaningful change threshold for worse baseline severity (n = 21). Conclusion: Methods used to assess baseline severity dependency for meaningful change thresholds vary, however most studies reviewed concluded that larger thresholds are warranted for worse baseline severity. Future work should explore how to distinguish true baseline severity dependency from statistical artifacts to ensure accurate interpretation of PROs in both clinical trials and clinical practice. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-025-03982-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 2489 Subjects: – SubjectFull: Patient reported outcome measures Type: general – SubjectFull: Severity of illness index Type: general – SubjectFull: Health outcome assessment Type: general – SubjectFull: Statistical bias Type: general – SubjectFull: Scholarly peer review Type: general – SubjectFull: Clinical trials Type: general Titles: – TitleFull: A literature review exploring whether meaningful change threshold estimates for patient-reported outcome (PRO) measures vary depending on baseline severity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sims, Joel – PersonEntity: Name: NameFull: Trigg, Andrew – PersonEntity: Name: NameFull: Flynn, Jessica – PersonEntity: Name: NameFull: Lydon, Aoife – PersonEntity: Name: NameFull: Griffiths, Natasha – PersonEntity: Name: NameFull: Cocks, Kim – PersonEntity: Name: NameFull: Arbuckle, Rob IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 34 – Type: issue Value: 9 Titles: – TitleFull: Quality of Life Research Type: main |
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