The proteome of the late Middle Pleistocene Harbin individual.
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| Title: | The proteome of the late Middle Pleistocene Harbin individual. |
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| Authors: | Fu, Qiaomei, Bai, Fan, Rao, Huiyun, Chen, Shaokun, Ji, Yannan, Liu, Aoran, Bennett, E. Andrew, Liu, Feng, Ji, Qiang |
| Source: | Science. 8/14/2025, Vol. 389 Issue 6761, p704-707. 4p. |
| Subjects: | Hominids, Proteomics, Biomolecules, Amino acids, Pleistocene Epoch |
| Abstract: | Denisovans are a hominin group primarily known through genomes or proteins, but their precise morphological features remain elusive because of the fragmentary nature of the discovered fossils. Here, we report 95 endogenous proteins retrieved from a nearly complete cranium from Harbin, China, dating to at least 146,000 years ago and previously assigned to a new species, Homo longi. This individual has three Denisovan-derived amino acid variants and clusters with Denisova 3, suggesting that the Harbin individual belongs to a Denisovan population. This study fills the gap between morphological and molecular evidence, enhancing our understanding of Denisovans' spatiotemporal dispersal and evolutionary history. Editor's summary: Ancient DNA has revealed a great deal about our history, especially admixture events with archaic hominins. However, DNA degrades much faster than other biomolecules such as proteins. Ancient proteomics may enhance our ability to study remains that are older and in environments inhospitable to DNA. Fu et al. analyzed ancient proteomic data from a 146,000-year-old cranium from Harbin, China. They identified 95 proteins with sufficient peptides and found that the amino acid variants were consistent with this individual being most closely related to Denisovans. Given the paucity of confirmed Denisovan remains, ancient proteomics may allow the increased identification of such individuals, enabling further study of these enigmatic hominins. —Corinne Simonti [ABSTRACT FROM AUTHOR] |
| Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 188103475 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The proteome of the late Middle Pleistocene Harbin individual. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fu%2C+Qiaomei%22">Fu, Qiaomei</searchLink><br /><searchLink fieldCode="AR" term="%22Bai%2C+Fan%22">Bai, Fan</searchLink><br /><searchLink fieldCode="AR" term="%22Rao%2C+Huiyun%22">Rao, Huiyun</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Shaokun%22">Chen, Shaokun</searchLink><br /><searchLink fieldCode="AR" term="%22Ji%2C+Yannan%22">Ji, Yannan</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Aoran%22">Liu, Aoran</searchLink><br /><searchLink fieldCode="AR" term="%22Bennett%2C+E%2E+Andrew%22">Bennett, E. Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Feng%22">Liu, Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Ji%2C+Qiang%22">Ji, Qiang</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science%22">Science</searchLink>. 8/14/2025, Vol. 389 Issue 6761, p704-707. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hominids%22">Hominids</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Biomolecules%22">Biomolecules</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Pleistocene+Epoch%22">Pleistocene Epoch</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Denisovans are a hominin group primarily known through genomes or proteins, but their precise morphological features remain elusive because of the fragmentary nature of the discovered fossils. Here, we report 95 endogenous proteins retrieved from a nearly complete cranium from Harbin, China, dating to at least 146,000 years ago and previously assigned to a new species, Homo longi. This individual has three Denisovan-derived amino acid variants and clusters with Denisova 3, suggesting that the Harbin individual belongs to a Denisovan population. This study fills the gap between morphological and molecular evidence, enhancing our understanding of Denisovans' spatiotemporal dispersal and evolutionary history. Editor's summary: Ancient DNA has revealed a great deal about our history, especially admixture events with archaic hominins. However, DNA degrades much faster than other biomolecules such as proteins. Ancient proteomics may enhance our ability to study remains that are older and in environments inhospitable to DNA. Fu et al. analyzed ancient proteomic data from a 146,000-year-old cranium from Harbin, China. They identified 95 proteins with sufficient peptides and found that the amino acid variants were consistent with this individual being most closely related to Denisovans. Given the paucity of confirmed Denisovan remains, ancient proteomics may allow the increased identification of such individuals, enabling further study of these enigmatic hominins. —Corinne Simonti [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.adu9677 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 704 Subjects: – SubjectFull: Hominids Type: general – SubjectFull: Proteomics Type: general – SubjectFull: Biomolecules Type: general – SubjectFull: Amino acids Type: general – SubjectFull: Pleistocene Epoch Type: general Titles: – TitleFull: The proteome of the late Middle Pleistocene Harbin individual. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fu, Qiaomei – PersonEntity: Name: NameFull: Bai, Fan – PersonEntity: Name: NameFull: Rao, Huiyun – PersonEntity: Name: NameFull: Chen, Shaokun – PersonEntity: Name: NameFull: Ji, Yannan – PersonEntity: Name: NameFull: Liu, Aoran – PersonEntity: Name: NameFull: Bennett, E. Andrew – PersonEntity: Name: NameFull: Liu, Feng – PersonEntity: Name: NameFull: Ji, Qiang IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 08 Text: 8/14/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 389 – Type: issue Value: 6761 Titles: – TitleFull: Science Type: main |
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