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Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit.

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Title: Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit.
Authors: Lyu, Cheng, Li, Zhuoran, Xu, Chuanyun, Wong, Kenneth Kin Lam, Luginbuhl, David J., McLaughlin, Colleen N., Xie, Qijing, Li, Tongchao, Li, Hongjie, Luo, Liqun
Source: Science. 5/1/2025, Vol. 388 Issue 6746, p538-544. 7p.
Subjects: Axons, Postsynaptic potential, Olfactory receptors, Neurons, Neural circuitry
Abstract: A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching. Editor's summary: How axons find their postsynaptic partners during development remains to be fully elucidated. Lyu et al. used the fly olfactory circuit as a model to identify general principles of neural circuit assembly (see the Perspective by Zhong and Desplan). By tracing dendrite and axon development of individual neurons, the authors showed that receptor neurons follow a predetermined trajectory on the surface of the antennal lobe. There, they encounter a small subset of projection neurons, thus reducing a three-dimensional search to an easier one-dimensional task. The dimensionality reduction principle shown here greatly simplifies the problem of synaptic partner matching in olfactory circuit assembly. —Mattia Maroso [ABSTRACT FROM AUTHOR]
Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit.
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  Data: <searchLink fieldCode="AR" term="%22Lyu%2C+Cheng%22">Lyu, Cheng</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Zhuoran%22">Li, Zhuoran</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+Chuanyun%22">Xu, Chuanyun</searchLink><br /><searchLink fieldCode="AR" term="%22Wong%2C+Kenneth+Kin+Lam%22">Wong, Kenneth Kin Lam</searchLink><br /><searchLink fieldCode="AR" term="%22Luginbuhl%2C+David+J%2E%22">Luginbuhl, David J.</searchLink><br /><searchLink fieldCode="AR" term="%22McLaughlin%2C+Colleen+N%2E%22">McLaughlin, Colleen N.</searchLink><br /><searchLink fieldCode="AR" term="%22Xie%2C+Qijing%22">Xie, Qijing</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Tongchao%22">Li, Tongchao</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hongjie%22">Li, Hongjie</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Liqun%22">Luo, Liqun</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science%22">Science</searchLink>. 5/1/2025, Vol. 388 Issue 6746, p538-544. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Axons%22">Axons</searchLink><br /><searchLink fieldCode="DE" term="%22Postsynaptic+potential%22">Postsynaptic potential</searchLink><br /><searchLink fieldCode="DE" term="%22Olfactory+receptors%22">Olfactory receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink>
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  Data: A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching. Editor's summary: How axons find their postsynaptic partners during development remains to be fully elucidated. Lyu et al. used the fly olfactory circuit as a model to identify general principles of neural circuit assembly (see the Perspective by Zhong and Desplan). By tracing dendrite and axon development of individual neurons, the authors showed that receptor neurons follow a predetermined trajectory on the surface of the antennal lobe. There, they encounter a small subset of projection neurons, thus reducing a three-dimensional search to an easier one-dimensional task. The dimensionality reduction principle shown here greatly simplifies the problem of synaptic partner matching in olfactory circuit assembly. —Mattia Maroso [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.ads7633
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        Text: English
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      – SubjectFull: Axons
        Type: general
      – SubjectFull: Postsynaptic potential
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      – SubjectFull: Olfactory receptors
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      – SubjectFull: Neurons
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      – SubjectFull: Neural circuitry
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      – TitleFull: Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit.
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            – D: 01
              M: 05
              Text: 5/1/2025
              Type: published
              Y: 2025
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