Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing.
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| Title: | Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing. |
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| Authors: | Sexton, Zachary A., Rütsche, Dominic, Herrmann, Jessica E., Hudson, Andrew R., Sinha, Soham, Du, Jianyi, Shiwarski, Daniel J., Masaltseva, Anastasiia, Solberg, Fredrik Samdal, Pham, Jonathan, Szafron, Jason M., Wu, Sean M., Feinberg, Adam W., Skylar-Scott, Mark A., Marsden, Alison L. |
| Source: | Science. 6/12/2025, Vol. 388 Issue 6752, p1198-1204. 7p. |
| Subjects: | Blood vessels, Bioprinting, Bioreactors, Fluid dynamics, Algorithms |
| Abstract: | Our ability to produce human-scale biomanufactured organs is limited by inadequate vascularization and perfusion. For arbitrarily complex geometries, designing and printing vasculature capable of adequate perfusion poses a major hurdle. We introduce a model-driven design platform that demonstrates rapid synthetic vascular model generation alongside multifidelity computational fluid dynamics simulations and three-dimensional bioprinting. Key algorithmic advances accelerate vascular generation 230-fold and enable application to arbitrarily complex shapes. We demonstrate that organ-scale vascular network models can be generated and used to computationally vascularize >200 engineered and anatomic models. Synthetic vascular perfusion improves cell viability in fabricated living-tissue constructs. This platform enables the rapid, scalable vascular model generation and fluid physics analysis for biomanufactured tissues that are necessary for future scale-up and production. Editor's summary: Whereas small clusters of cells can extract nutrients and oxygen from their surroundings, larger tissues need to have a vascular system to ensure sufficient transport and availability. This limitation is a challenge when engineering synthetic tissues because of the complexities of designing and then fabricating a vascular system. Sexton et al. developed a model-driven design platform to rapidly design vasculature trees for the generation of organ or tissue mimetics (see the Perspective by Huang and Ju). The model includes hemodynamic properties such as flow patterns and pressure in the context of branching points and hierarchical trees, enabling the fabrication of arbitrarily complex shapes. The authors demonstrate perfusion of three-dimensional bioprinted vascular networks in a bioreactor that show improved cell viability. —Marc S. Lavine [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Our ability to produce human-scale biomanufactured organs is limited by inadequate vascularization and perfusion. For arbitrarily complex geometries, designing and printing vasculature capable of adequate perfusion poses a major hurdle. We introduce a model-driven design platform that demonstrates rapid synthetic vascular model generation alongside multifidelity computational fluid dynamics simulations and three-dimensional bioprinting. Key algorithmic advances accelerate vascular generation 230-fold and enable application to arbitrarily complex shapes. We demonstrate that organ-scale vascular network models can be generated and used to computationally vascularize >200 engineered and anatomic models. Synthetic vascular perfusion improves cell viability in fabricated living-tissue constructs. This platform enables the rapid, scalable vascular model generation and fluid physics analysis for biomanufactured tissues that are necessary for future scale-up and production. Editor's summary: Whereas small clusters of cells can extract nutrients and oxygen from their surroundings, larger tissues need to have a vascular system to ensure sufficient transport and availability. This limitation is a challenge when engineering synthetic tissues because of the complexities of designing and then fabricating a vascular system. Sexton et al. developed a model-driven design platform to rapidly design vasculature trees for the generation of organ or tissue mimetics (see the Perspective by Huang and Ju). The model includes hemodynamic properties such as flow patterns and pressure in the context of branching points and hierarchical trees, enabling the fabrication of arbitrarily complex shapes. The authors demonstrate perfusion of three-dimensional bioprinted vascular networks in a bioreactor that show improved cell viability. —Marc S. Lavine [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.adj6152 |
