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Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.

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Title: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.
Authors: Hetherington‐Rauth, Megan, Mansfield, Tyler A., Lenchik, Leon, Weaver, Ashley A., Cawthon, Peggy M.
Source: Journal of the American Geriatrics Society. Sep2025, Vol. 73 Issue 9, p2717-2726. 10p.
Subjects: Bone fractures -- Prognosis, Mortality risk factors, Risk assessment, Pearson correlation (Statistics), Skeletal muscle, Adipose tissues, Research funding, Secondary analysis, Computed tomography, Scientific observation, Fisher exact test, Questionnaires, Functional status, Descriptive statistics, Chi-squared test, Bone fractures, Longitudinal method, Muscle strength, Lumbar vertebrae, Thigh, Analysis of variance, Osteoporosis, Data analysis software, Walking speed, Survival analysis (Biometry), Exercise tests, Sarcopenia, Regression analysis, Proportional hazards models, Grip strength, Muscle contraction, Old age
Abstract: Background: The automated segmentation of computed tomography (CT) images has made their opportunistic use more feasible, yet, the association of muscle area and density from multiple anatomical regions with functional outcomes and mortality risk in older adults has not been fully explored. We aimed to determine if muscle area and density at the L1 and L3 vertebra and right and left proximal thigh were similarly related to functional outcomes and 10‐year mortality risk. Methods: Men from the Osteoporotic Fractures in Men (MrOS) study who had CT images, measures of grip strength, 6 m walking speed, and leg power (Nottingham Power Rig) at the baseline visit were included in the analyses (n = 3290, 73.7 ± 5.8 years). CT images were automatically segmented to derive muscle area and muscle density. Deaths were centrally adjudicated over a 10‐year follow‐up. Linear regression and proportional hazards were used to model relationships of CT muscle metrics with functional outcomes and mortality, respectively, while adjusting for covariates. Results: Muscle area and density were positively related to functional outcomes regardless of anatomical region, with the most variance explained in leg power (adjusted R2 = 0.40–0.46), followed by grip strength (adjusted R2 = 0.25–0.29) and walking speed (adjusted R2 = 0.18–0.20). A one‐unit SD increase in muscle area and density was associated with a 5%–13% and 8%–21% decrease in the risk of all‐cause mortality, respectively, with the strongest associations observed at the right and left thigh. Conclusion: Automated measures of CT muscle area and density are related to functional outcomes and risk of mortality in older men, regardless of CT anatomical region. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.
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  Data: <searchLink fieldCode="AR" term="%22Hetherington‐Rauth%2C+Megan%22">Hetherington‐Rauth, Megan</searchLink><br /><searchLink fieldCode="AR" term="%22Mansfield%2C+Tyler+A%2E%22">Mansfield, Tyler A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lenchik%2C+Leon%22">Lenchik, Leon</searchLink><br /><searchLink fieldCode="AR" term="%22Weaver%2C+Ashley+A%2E%22">Weaver, Ashley A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cawthon%2C+Peggy+M%2E%22">Cawthon, Peggy M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Geriatrics+Society%22">Journal of the American Geriatrics Society</searchLink>. Sep2025, Vol. 73 Issue 9, p2717-2726. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Bone+fractures+--+Prognosis%22">Bone fractures -- Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality+risk+factors%22">Mortality risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Skeletal+muscle%22">Skeletal muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Adipose+tissues%22">Adipose tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+fractures%22">Bone fractures</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+strength%22">Muscle strength</searchLink><br /><searchLink fieldCode="DE" term="%22Lumbar+vertebrae%22">Lumbar vertebrae</searchLink><br /><searchLink fieldCode="DE" term="%22Thigh%22">Thigh</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoporosis%22">Osteoporosis</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Walking+speed%22">Walking speed</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+tests%22">Exercise tests</searchLink><br /><searchLink fieldCode="DE" term="%22Sarcopenia%22">Sarcopenia</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Grip+strength%22">Grip strength</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+contraction%22">Muscle contraction</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The automated segmentation of computed tomography (CT) images has made their opportunistic use more feasible, yet, the association of muscle area and density from multiple anatomical regions with functional outcomes and mortality risk in older adults has not been fully explored. We aimed to determine if muscle area and density at the L1 and L3 vertebra and right and left proximal thigh were similarly related to functional outcomes and 10‐year mortality risk. Methods: Men from the Osteoporotic Fractures in Men (MrOS) study who had CT images, measures of grip strength, 6 m walking speed, and leg power (Nottingham Power Rig) at the baseline visit were included in the analyses (n = 3290, 73.7 ± 5.8 years). CT images were automatically segmented to derive muscle area and muscle density. Deaths were centrally adjudicated over a 10‐year follow‐up. Linear regression and proportional hazards were used to model relationships of CT muscle metrics with functional outcomes and mortality, respectively, while adjusting for covariates. Results: Muscle area and density were positively related to functional outcomes regardless of anatomical region, with the most variance explained in leg power (adjusted R2 = 0.40–0.46), followed by grip strength (adjusted R2 = 0.25–0.29) and walking speed (adjusted R2 = 0.18–0.20). A one‐unit SD increase in muscle area and density was associated with a 5%–13% and 8%–21% decrease in the risk of all‐cause mortality, respectively, with the strongest associations observed at the right and left thigh. Conclusion: Automated measures of CT muscle area and density are related to functional outcomes and risk of mortality in older men, regardless of CT anatomical region. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jgs.19583
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 2717
    Subjects:
      – SubjectFull: Bone fractures -- Prognosis
        Type: general
      – SubjectFull: Mortality risk factors
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Skeletal muscle
        Type: general
      – SubjectFull: Adipose tissues
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Secondary analysis
        Type: general
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Scientific observation
        Type: general
      – SubjectFull: Fisher exact test
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Bone fractures
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Muscle strength
        Type: general
      – SubjectFull: Lumbar vertebrae
        Type: general
      – SubjectFull: Thigh
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Osteoporosis
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Walking speed
        Type: general
      – SubjectFull: Survival analysis (Biometry)
        Type: general
      – SubjectFull: Exercise tests
        Type: general
      – SubjectFull: Sarcopenia
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Grip strength
        Type: general
      – SubjectFull: Muscle contraction
        Type: general
      – SubjectFull: Old age
        Type: general
    Titles:
      – TitleFull: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.
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            NameFull: Hetherington‐Rauth, Megan
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            NameFull: Mansfield, Tyler A.
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            NameFull: Lenchik, Leon
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            NameFull: Weaver, Ashley A.
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            – D: 01
              M: 09
              Text: Sep2025
              Type: published
              Y: 2025
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