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The mediation effect of treatment fatigue in the association between memory and health-related quality of life in men with HIV who have sex with men.

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Title: The mediation effect of treatment fatigue in the association between memory and health-related quality of life in men with HIV who have sex with men.
Authors: Alcocer-Bruno, C. (AUTHOR), Ferrer-Cascales, R. (AUTHOR), Ruiz-Robledillo, N. (AUTHOR), Clement-Carbonell, V. (AUTHOR)
Source: Applied Neuropsychology: Adult. Nov/Dec2025, Vol. 32 Issue 6, p1643-1653. 11p.
Subjects: HIV, Memory, Quality of life, Cognitive ability, Patient compliance, Men who have sex with men, Fatigue (Physiology), Mediation (Statistics)
Abstract: Approximately half of all adults living with the Human Immunodeficiency Virus (HIV) experience cognitive alterations related to difficulties in treatment adherence and, therefore, to a significant decrease in quality of life. In this sense, new studies are needed to identify potential mediators related to treatment in this association, such as treatment fatigue. This fact is especially important in at specific groups of individuals with HIV, namely men with HIV who have sex with men (MSM). The objective of this study was to analyze the association between cognitive functioning, Health-Related Quality of Life (HRQoL), and treatment fatigue in MSM with HIV. A cross-sectional study was developed with a sample of 70 MSM, from the Infectious Diseases Unit of the General University Hospital of Alicante (Spain). Participants completed questionnaires related to sociodemographic data, HRQoL, and treatment fatigue in an initial phase; in a second phase, they were administered a computerized cognitive evaluation. Our results demonstrate a significant relationship between a lower cognitive performance in the memory domain and worse HRQoL. Mediation analysis has revealed the total mediation effect of treatment fatigue, specifically, the treatment cynicism domain, on this relationship. This mediation effect remained significant after controlling the sociodemographic and clinical HIV-related variables in the model. No significant mediation effects of the rest of evaluated cognitive domains (attention, perception, reasoning, or coordination) were found in this relationship. The results of this study highlight how MSM with a significant deterioration of memory are at greater risk of developing high levels of treatment fatigue, and, therefore, a lower adherence to the same and a significant deterioration in their HRQoL. [ABSTRACT FROM AUTHOR]
Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The mediation effect of treatment fatigue in the association between memory and health-related quality of life in men with HIV who have sex with men.
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  Data: <searchLink fieldCode="AR" term="%22Alcocer-Bruno%2C+C%2E%22">Alcocer-Bruno, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrer-Cascales%2C+R%2E%22">Ferrer-Cascales, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruiz-Robledillo%2C+N%2E%22">Ruiz-Robledillo, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clement-Carbonell%2C+V%2E%22">Clement-Carbonell, V.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. Nov/Dec2025, Vol. 32 Issue 6, p1643-1653. 11p.
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  Data: <searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Men+who+have+sex+with+men%22">Men who have sex with men</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mediation+%28Statistics%29%22">Mediation (Statistics)</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Approximately half of all adults living with the Human Immunodeficiency Virus (HIV) experience cognitive alterations related to difficulties in treatment adherence and, therefore, to a significant decrease in quality of life. In this sense, new studies are needed to identify potential mediators related to treatment in this association, such as treatment fatigue. This fact is especially important in at specific groups of individuals with HIV, namely men with HIV who have sex with men (MSM). The objective of this study was to analyze the association between cognitive functioning, Health-Related Quality of Life (HRQoL), and treatment fatigue in MSM with HIV. A cross-sectional study was developed with a sample of 70 MSM, from the Infectious Diseases Unit of the General University Hospital of Alicante (Spain). Participants completed questionnaires related to sociodemographic data, HRQoL, and treatment fatigue in an initial phase; in a second phase, they were administered a computerized cognitive evaluation. Our results demonstrate a significant relationship between a lower cognitive performance in the memory domain and worse HRQoL. Mediation analysis has revealed the total mediation effect of treatment fatigue, specifically, the treatment cynicism domain, on this relationship. This mediation effect remained significant after controlling the sociodemographic and clinical HIV-related variables in the model. No significant mediation effects of the rest of evaluated cognitive domains (attention, perception, reasoning, or coordination) were found in this relationship. The results of this study highlight how MSM with a significant deterioration of memory are at greater risk of developing high levels of treatment fatigue, and, therefore, a lower adherence to the same and a significant deterioration in their HRQoL. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/23279095.2023.2298375
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        Text: English
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        Type: general
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      – SubjectFull: Patient compliance
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      – SubjectFull: Men who have sex with men
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      – SubjectFull: Fatigue (Physiology)
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      – SubjectFull: Mediation (Statistics)
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      – TitleFull: The mediation effect of treatment fatigue in the association between memory and health-related quality of life in men with HIV who have sex with men.
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              Text: Nov/Dec2025
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