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Primary progressive aphasia and amyotrophic lateral sclerosis (PPA-ALS): A longitudinal case study.

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Title: Primary progressive aphasia and amyotrophic lateral sclerosis (PPA-ALS): A longitudinal case study.
Authors: Hromas, Gabrielle (AUTHOR), Jackson, Carlayne E. (AUTHOR), Cooper, Douglas B. (AUTHOR), Sullivan, A. Campbell (AUTHOR)
Source: Applied Neuropsychology: Adult. Nov/Dec2025, Vol. 32 Issue 6, p1819-1822. 4p.
Subjects: Amyotrophic lateral sclerosis, Frontotemporal dementia, Longitudinal method, Aphasic persons, Speech disorders, Cognition disorders, Patient care, Neuropsychological tests
Abstract: Objective: Approximately 50% of patients with amyotrophic lateral sclerosis (ALS) experience cognitive decline, with frontotemporal dementia (FTD) accounting for up to 15% of these cases. Despite this, there is considerable delay in diagnosis, which affects patient care. Methods: We report longitudinal results of neuropsychological evaluations in a patient diagnosed with non-fluent/agrammatic primary progressive aphasia (nfvPPA) and amyotrophic lateral sclerosis (ALS). The patient, Ms. X, presented with progressive speech difficulties starting in her late-60's. Initial diagnosis was nfvPPA. After 4–5 years of progressive swallowing difficulties, as well as facial weakness, her diagnosis was modified to PPA-ALS. Results: Ms. X underwent neuropsychological evaluations three times over a period of five years. Results of evaluations were intact and stable over time, except for progressive loss of speech impacting her performance on a sentence repetition task. Conclusion: This case study provides valuable insight into the overlap between PPA-ALS from a neuropsychological standpoint. The results reflect preserved cognitive skills in the context of loss of speech and motor abilities. This case study also shows the length of time between onset of symptoms and clear diagnosis, which often requires an immense amount of health literacy and personal advocacy on the part of the patient. [ABSTRACT FROM AUTHOR]
Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Primary progressive aphasia and amyotrophic lateral sclerosis (PPA-ALS): A longitudinal case study.
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  Data: <searchLink fieldCode="AR" term="%22Hromas%2C+Gabrielle%22">Hromas, Gabrielle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jackson%2C+Carlayne+E%2E%22">Jackson, Carlayne E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cooper%2C+Douglas+B%2E%22">Cooper, Douglas B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sullivan%2C+A%2E+Campbell%22">Sullivan, A. Campbell</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. Nov/Dec2025, Vol. 32 Issue 6, p1819-1822. 4p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Frontotemporal+dementia%22">Frontotemporal dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Aphasic+persons%22">Aphasic persons</searchLink><br /><searchLink fieldCode="DE" term="%22Speech+disorders%22">Speech disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+care%22">Patient care</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: Approximately 50% of patients with amyotrophic lateral sclerosis (ALS) experience cognitive decline, with frontotemporal dementia (FTD) accounting for up to 15% of these cases. Despite this, there is considerable delay in diagnosis, which affects patient care. Methods: We report longitudinal results of neuropsychological evaluations in a patient diagnosed with non-fluent/agrammatic primary progressive aphasia (nfvPPA) and amyotrophic lateral sclerosis (ALS). The patient, Ms. X, presented with progressive speech difficulties starting in her late-60's. Initial diagnosis was nfvPPA. After 4–5 years of progressive swallowing difficulties, as well as facial weakness, her diagnosis was modified to PPA-ALS. Results: Ms. X underwent neuropsychological evaluations three times over a period of five years. Results of evaluations were intact and stable over time, except for progressive loss of speech impacting her performance on a sentence repetition task. Conclusion: This case study provides valuable insight into the overlap between PPA-ALS from a neuropsychological standpoint. The results reflect preserved cognitive skills in the context of loss of speech and motor abilities. This case study also shows the length of time between onset of symptoms and clear diagnosis, which often requires an immense amount of health literacy and personal advocacy on the part of the patient. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/23279095.2024.2302833
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        Text: English
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      – TitleFull: Primary progressive aphasia and amyotrophic lateral sclerosis (PPA-ALS): A longitudinal case study.
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              Text: Nov/Dec2025
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