View in EDS

The association between sugar- and artificially sweetened beverages and risk of Alzheimer's disease: systematic review and dose-response meta-analysis of prospective cohort studies.

Saved in:
Bibliographic Details
Title: The association between sugar- and artificially sweetened beverages and risk of Alzheimer's disease: systematic review and dose-response meta-analysis of prospective cohort studies.
Authors: Jouni, Nagham (AUTHOR), Torabinasab, Kimia (AUTHOR), Amiri, Seyede Motahare (AUTHOR), Jahangir Kozehkonani, Fatemeh (AUTHOR), Talebi, Sepide (AUTHOR), Amiri Khosroshahi, Reza (AUTHOR), Jafarian, Mehdi (AUTHOR), Khalife, Hala (AUTHOR), Djafarian, Kurosh (AUTHOR)
Source: Aging & Mental Health. Oct2025, Vol. 29 Issue 10, p1845-1855. 11p.
Subjects: Alzheimer's disease risk factors, Carbonated beverages, Drinking (Physiology), Risk assessment, World Wide Web, Meta-analysis, Descriptive statistics, Systematic reviews, MEDLINE, Food habits, Online information services, Confidence intervals, Beverages, Sweeteners
Abstract: Objectives: This study aimed to systematically review and meta-analyse prospective cohort studies to evaluate the association between consumption of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and soft drinks with the risk of AD. Methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted up to September 2024 to identify observational studies reporting on the association between sweetened beverages and AD risk. A random-effects model was used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). The risk of bias was assessed using the ROBINS-I tool, and the GRADE approach was used to evaluate the certainty of the evidence. Results: Nine studies met the inclusion criteria; seven were included in the meta-analysis. Higher SSB intake was associated with increased AD risk (RR: 1.49; 95% CI: 1.03–2.15; I2 = 79.0%), with dose-response analyses supporting a linear association. ASB intake was also positively associated with AD risk (RR: 1.42; 95% CI: 1.14–1.78; I2 = 0.0%). No significant association was observed between soft drinks intake and AD (RR: 1.13; 95% CI: 0.83–1.55). The certainty of evidence was rated as moderate for both SSB and ASB. Conclusion: Increased intake of SSBs and ASBs may elevate the risk of AD. Further research is required to clarify causal mechanisms and strengthen the evidence for public health recommendations aimed at reducing sugar consumption to prevent cognitive decline and AD. Registration: PROSPERO (CRD42024574650). [ABSTRACT FROM AUTHOR]
Copyright of Aging & Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 188423559
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The association between sugar- and artificially sweetened beverages and risk of Alzheimer's disease: systematic review and dose-response meta-analysis of prospective cohort studies.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Jouni%2C+Nagham%22">Jouni, Nagham</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torabinasab%2C+Kimia%22">Torabinasab, Kimia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amiri%2C+Seyede+Motahare%22">Amiri, Seyede Motahare</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jahangir+Kozehkonani%2C+Fatemeh%22">Jahangir Kozehkonani, Fatemeh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Talebi%2C+Sepide%22">Talebi, Sepide</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amiri+Khosroshahi%2C+Reza%22">Amiri Khosroshahi, Reza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jafarian%2C+Mehdi%22">Jafarian, Mehdi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khalife%2C+Hala%22">Khalife, Hala</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Djafarian%2C+Kurosh%22">Djafarian, Kurosh</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Aging+%26+Mental+Health%22">Aging & Mental Health</searchLink>. Oct2025, Vol. 29 Issue 10, p1845-1855. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease+risk+factors%22">Alzheimer's disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Carbonated+beverages%22">Carbonated beverages</searchLink><br /><searchLink fieldCode="DE" term="%22Drinking+%28Physiology%29%22">Drinking (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22World+Wide+Web%22">World Wide Web</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Food+habits%22">Food habits</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Beverages%22">Beverages</searchLink><br /><searchLink fieldCode="DE" term="%22Sweeteners%22">Sweeteners</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This study aimed to systematically review and meta-analyse prospective cohort studies to evaluate the association between consumption of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and soft drinks with the risk of AD. Methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted up to September 2024 to identify observational studies reporting on the association between sweetened beverages and AD risk. A random-effects model was used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). The risk of bias was assessed using the ROBINS-I tool, and the GRADE approach was used to evaluate the certainty of the evidence. Results: Nine studies met the inclusion criteria; seven were included in the meta-analysis. Higher SSB intake was associated with increased AD risk (RR: 1.49; 95% CI: 1.03–2.15; I2 = 79.0%), with dose-response analyses supporting a linear association. ASB intake was also positively associated with AD risk (RR: 1.42; 95% CI: 1.14–1.78; I2 = 0.0%). No significant association was observed between soft drinks intake and AD (RR: 1.13; 95% CI: 0.83–1.55). The certainty of evidence was rated as moderate for both SSB and ASB. Conclusion: Increased intake of SSBs and ASBs may elevate the risk of AD. Further research is required to clarify causal mechanisms and strengthen the evidence for public health recommendations aimed at reducing sugar consumption to prevent cognitive decline and AD. Registration: PROSPERO (CRD42024574650). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Aging & Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=188423559
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/13607863.2025.2512215
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1845
    Subjects:
      – SubjectFull: Alzheimer's disease risk factors
        Type: general
      – SubjectFull: Carbonated beverages
        Type: general
      – SubjectFull: Drinking (Physiology)
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: World Wide Web
        Type: general
      – SubjectFull: Meta-analysis
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: MEDLINE
        Type: general
      – SubjectFull: Food habits
        Type: general
      – SubjectFull: Online information services
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Beverages
        Type: general
      – SubjectFull: Sweeteners
        Type: general
    Titles:
      – TitleFull: The association between sugar- and artificially sweetened beverages and risk of Alzheimer's disease: systematic review and dose-response meta-analysis of prospective cohort studies.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jouni, Nagham
      – PersonEntity:
          Name:
            NameFull: Torabinasab, Kimia
      – PersonEntity:
          Name:
            NameFull: Amiri, Seyede Motahare
      – PersonEntity:
          Name:
            NameFull: Jahangir Kozehkonani, Fatemeh
      – PersonEntity:
          Name:
            NameFull: Talebi, Sepide
      – PersonEntity:
          Name:
            NameFull: Amiri Khosroshahi, Reza
      – PersonEntity:
          Name:
            NameFull: Jafarian, Mehdi
      – PersonEntity:
          Name:
            NameFull: Khalife, Hala
      – PersonEntity:
          Name:
            NameFull: Djafarian, Kurosh
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 13607863
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Aging & Mental Health
              Type: main
ResultId 1