Neurocognitive function as outcome and predictor for prefrontal transcranial direct current stimulation in major depressive disorder: an analysis from the DepressionDC trial.
Saved in:
| Title: | Neurocognitive function as outcome and predictor for prefrontal transcranial direct current stimulation in major depressive disorder: an analysis from the DepressionDC trial. |
|---|---|
| Authors: | Soldini, Aldo (AUTHOR), Vogelmann, Ulrike (AUTHOR), Aust, Sabine (AUTHOR), Goerigk, Stephan (AUTHOR), Plewnia, Christian (AUTHOR), Fallgatter, Andreas (AUTHOR), Normann, Claus (AUTHOR), Frase, Lukas (AUTHOR), Zwanzger, Peter (AUTHOR), Kammer, Thomas (AUTHOR), Schönfeldt-Lecuona, Carlos (AUTHOR), Vural, Gizem (AUTHOR), Bajbouj, Malek (AUTHOR), Padberg, Frank (AUTHOR), Burkhardt, Gerrit (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Sep2025, Vol. 275 Issue 6, p1715-1724. 10p. |
| Subjects: | Transcranial direct current stimulation, Mental depression, Executive function, Randomized controlled trials, Treatment effectiveness, Cognitive ability |
| Abstract: | Transcranial direct current stimulation (tDCS) of the prefrontal cortex might beneficially influence neurocognitive dysfunctions associated with major depressive disorder (MDD). However, previous studies of neurocognitive effects of tDCS have been inconclusive. In the current study, we analyzed longitudinal, neurocognitive data from 101 participants of a randomized controlled multicenter trial (DepressionDC), investigating the efficacy of bifrontal tDCS (2 mA, 30 min/d, for 6 weeks) in patients with MDD and insufficient response to selective serotonin reuptake inhibitors (SSRI). We assessed whether active tDCS compared to sham tDCS elicited beneficial effects across the domains of memory span, working memory, selective attention, sustained attention, executive process, and processing speed, assessed with a validated, digital test battery. Additionally, we explored whether baseline cognitive performance, as a proxy of fronto-parietal-network functioning, predicts the antidepressant effects of active tDCS versus sham tDCS. We found no statistically significant group differences in the change of neurocognitive performance between active and sham tDCS. Furthermore, baseline cognitive performance did not predict the clinical response to tDCS. Our findings indicate no advantage in neurocognition due to active tDCS in MDD. Additional research is required to systematically investigate the effects of tDCS protocols on neurocognitive performance in patients with MDD. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 188476029 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Neurocognitive function as outcome and predictor for prefrontal transcranial direct current stimulation in major depressive disorder: an analysis from the DepressionDC trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Soldini%2C+Aldo%22">Soldini, Aldo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vogelmann%2C+Ulrike%22">Vogelmann, Ulrike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aust%2C+Sabine%22">Aust, Sabine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goerigk%2C+Stephan%22">Goerigk, Stephan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plewnia%2C+Christian%22">Plewnia, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fallgatter%2C+Andreas%22">Fallgatter, Andreas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Normann%2C+Claus%22">Normann, Claus</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frase%2C+Lukas%22">Frase, Lukas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zwanzger%2C+Peter%22">Zwanzger, Peter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kammer%2C+Thomas%22">Kammer, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schönfeldt-Lecuona%2C+Carlos%22">Schönfeldt-Lecuona, Carlos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vural%2C+Gizem%22">Vural, Gizem</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bajbouj%2C+Malek%22">Bajbouj, Malek</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Padberg%2C+Frank%22">Padberg, Frank</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burkhardt%2C+Gerrit%22">Burkhardt, Gerrit</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Sep2025, Vol. 275 Issue 6, p1715-1724. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Transcranial+direct+current+stimulation%22">Transcranial direct current stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Executive+function%22">Executive function</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Transcranial direct current stimulation (tDCS) of the prefrontal cortex might beneficially influence neurocognitive dysfunctions associated with major depressive disorder (MDD). However, previous studies of neurocognitive effects of tDCS have been inconclusive. In the current study, we analyzed longitudinal, neurocognitive data from 101 participants of a randomized controlled multicenter trial (DepressionDC), investigating the efficacy of bifrontal tDCS (2 mA, 30 min/d, for 6 weeks) in patients with MDD and insufficient response to selective serotonin reuptake inhibitors (SSRI). We assessed whether active tDCS compared to sham tDCS elicited beneficial effects across the domains of memory span, working memory, selective attention, sustained attention, executive process, and processing speed, assessed with a validated, digital test battery. Additionally, we explored whether baseline cognitive performance, as a proxy of fronto-parietal-network functioning, predicts the antidepressant effects of active tDCS versus sham tDCS. We found no statistically significant group differences in the change of neurocognitive performance between active and sham tDCS. Furthermore, baseline cognitive performance did not predict the clinical response to tDCS. Our findings indicate no advantage in neurocognition due to active tDCS in MDD. Additional research is required to systematically investigate the effects of tDCS protocols on neurocognitive performance in patients with MDD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=188476029 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-024-01759-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1715 Subjects: – SubjectFull: Transcranial direct current stimulation Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Executive function Type: general – SubjectFull: Randomized controlled trials Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Cognitive ability Type: general Titles: – TitleFull: Neurocognitive function as outcome and predictor for prefrontal transcranial direct current stimulation in major depressive disorder: an analysis from the DepressionDC trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Soldini, Aldo – PersonEntity: Name: NameFull: Vogelmann, Ulrike – PersonEntity: Name: NameFull: Aust, Sabine – PersonEntity: Name: NameFull: Goerigk, Stephan – PersonEntity: Name: NameFull: Plewnia, Christian – PersonEntity: Name: NameFull: Fallgatter, Andreas – PersonEntity: Name: NameFull: Normann, Claus – PersonEntity: Name: NameFull: Frase, Lukas – PersonEntity: Name: NameFull: Zwanzger, Peter – PersonEntity: Name: NameFull: Kammer, Thomas – PersonEntity: Name: NameFull: Schönfeldt-Lecuona, Carlos – PersonEntity: Name: NameFull: Vural, Gizem – PersonEntity: Name: NameFull: Bajbouj, Malek – PersonEntity: Name: NameFull: Padberg, Frank – PersonEntity: Name: NameFull: Burkhardt, Gerrit IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 275 – Type: issue Value: 6 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
| ResultId | 1 |
