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Neural activation during processing of emotional faces as a function of resilience in adolescents.

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Title: Neural activation during processing of emotional faces as a function of resilience in adolescents.
Authors: Eaton, Steve (AUTHOR), Cornwell, Harriet (AUTHOR), Rogers, Jack (AUTHOR), De Brito, Stephane (AUTHOR), Toschi, Nicola (AUTHOR), Stadler, Christina (AUTHOR), Raschle, Nora (AUTHOR), Konrad, Kerstin (AUTHOR), Kohls, Gregor (AUTHOR), Smaragdi, Areti (AUTHOR), Gonzalez-Madruga, Karen (AUTHOR), Oosterling, Maaike (AUTHOR), Martinelli, Anne (AUTHOR), Bernhard, Anka (AUTHOR), Freitag, Christine M. (AUTHOR), Hamilton-Giachritsis, Catherine (AUTHOR), Fairchild, Graeme (AUTHOR)
Source: European Child & Adolescent Psychiatry. Sep2025, Vol. 34 Issue 9, p2943-2955. 13p.
Subjects: Psychological resilience, Fear, Research funding, Amygdaloid body, Data analysis, Brain, Neural pathways, Prefrontal cortex, Anger, Sex distribution, Questionnaires, Emotions, Magnetic resonance imaging, Age distribution, Descriptive statistics, Statistics, Child Behavior Checklist, Hippocampus (Brain), Factor analysis, Facial expression, Thought & thinking, Pathological psychology, Regression analysis, Adolescence
Abstract: Neuroimaging studies suggest that resilience to adversity is linked to reduced emotional reactivity or enhanced emotion regulation. However, such studies are scarce and mainly use adult samples and categorical definitions of resilience. Using a novel, data-driven approach to define resilience dimensionally, based on cumulative adversity exposure across childhood and psychopathology, we investigated associations between resilience and brain activation during facial emotion processing in youth. We also tested for sex differences in the relationship between resilience and brain activation. fMRI data were acquired from 208 youths (aged 9–18 years; Mean age = 13.28), while viewing angry, fearful, and neutral faces. Whole-brain analyses were performed, followed by region-of-interest analyses focusing on the amygdala, hippocampus, and prefrontal cortex. Resilience was positively correlated with bilateral inferior frontal gyrus responses to fearful (versus neutral) faces, and negatively correlated with right superior temporal gyrus, left hippocampal, and right inferior frontal gyrus responses to neutral faces (versus fixation). Sex-by-resilience interactions were observed in the medial prefrontal cortex: males showed positive, while females showed negative, associations between resilience and brain activation, though these results did not survive correction for multiple comparisons. These findings provide further evidence that resilience in youth is associated with enhanced emotion regulation at a neural level. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Neural activation during processing of emotional faces as a function of resilience in adolescents.
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  Data: <searchLink fieldCode="AR" term="%22Eaton%2C+Steve%22">Eaton, Steve</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cornwell%2C+Harriet%22">Cornwell, Harriet</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rogers%2C+Jack%22">Rogers, Jack</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Brito%2C+Stephane%22">De Brito, Stephane</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toschi%2C+Nicola%22">Toschi, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stadler%2C+Christina%22">Stadler, Christina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raschle%2C+Nora%22">Raschle, Nora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Konrad%2C+Kerstin%22">Konrad, Kerstin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kohls%2C+Gregor%22">Kohls, Gregor</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smaragdi%2C+Areti%22">Smaragdi, Areti</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gonzalez-Madruga%2C+Karen%22">Gonzalez-Madruga, Karen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oosterling%2C+Maaike%22">Oosterling, Maaike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martinelli%2C+Anne%22">Martinelli, Anne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernhard%2C+Anka%22">Bernhard, Anka</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freitag%2C+Christine+M%2E%22">Freitag, Christine M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hamilton-Giachritsis%2C+Catherine%22">Hamilton-Giachritsis, Catherine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fairchild%2C+Graeme%22">Fairchild, Graeme</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Sep2025, Vol. 34 Issue 9, p2943-2955. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Psychological+resilience%22">Psychological resilience</searchLink><br /><searchLink fieldCode="DE" term="%22Fear%22">Fear</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+pathways%22">Neural pathways</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Anger%22">Anger</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Emotions%22">Emotions</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Behavior+Checklist%22">Child Behavior Checklist</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Factor+analysis%22">Factor analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Facial+expression%22">Facial expression</searchLink><br /><searchLink fieldCode="DE" term="%22Thought+%26+thinking%22">Thought & thinking</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Neuroimaging studies suggest that resilience to adversity is linked to reduced emotional reactivity or enhanced emotion regulation. However, such studies are scarce and mainly use adult samples and categorical definitions of resilience. Using a novel, data-driven approach to define resilience dimensionally, based on cumulative adversity exposure across childhood and psychopathology, we investigated associations between resilience and brain activation during facial emotion processing in youth. We also tested for sex differences in the relationship between resilience and brain activation. fMRI data were acquired from 208 youths (aged 9–18 years; Mean age = 13.28), while viewing angry, fearful, and neutral faces. Whole-brain analyses were performed, followed by region-of-interest analyses focusing on the amygdala, hippocampus, and prefrontal cortex. Resilience was positively correlated with bilateral inferior frontal gyrus responses to fearful (versus neutral) faces, and negatively correlated with right superior temporal gyrus, left hippocampal, and right inferior frontal gyrus responses to neutral faces (versus fixation). Sex-by-resilience interactions were observed in the medial prefrontal cortex: males showed positive, while females showed negative, associations between resilience and brain activation, though these results did not survive correction for multiple comparisons. These findings provide further evidence that resilience in youth is associated with enhanced emotion regulation at a neural level. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-025-02703-y
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      – Code: eng
        Text: English
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        StartPage: 2943
    Subjects:
      – SubjectFull: Psychological resilience
        Type: general
      – SubjectFull: Fear
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Amygdaloid body
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      – SubjectFull: Data analysis
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      – SubjectFull: Brain
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      – SubjectFull: Neural pathways
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      – SubjectFull: Prefrontal cortex
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      – SubjectFull: Anger
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      – SubjectFull: Sex distribution
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      – SubjectFull: Emotions
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      – SubjectFull: Adolescence
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