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Prefrontal-hippocampal pathways underlying adolescent resilience.

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Title: Prefrontal-hippocampal pathways underlying adolescent resilience.
Authors: Wei, Luqing (AUTHOR), Wu, Zhengdong (AUTHOR), Xia, Qi (AUTHOR), Baeken, Chris (AUTHOR), Wu, Guo-Rong (AUTHOR)
Source: European Child & Adolescent Psychiatry. Sep2025, Vol. 34 Issue 9, p2815-2823. 9p.
Subjects: Psychological resilience, Pearson correlation (Statistics), Research funding, T-test (Statistics), Statistical hypothesis testing, Functional connectivity, Physiological adaptation, Prefrontal cortex, Neural pathways, Questionnaires, Magnetic resonance imaging, Descriptive statistics, Chi-squared test, Teenagers' conduct of life, Gray matter (Nerve tissue), Memory, Hippocampus (Brain), Cholinergic receptors, Space perception, Data analysis software, Molecular biology, Drugs, Serotonin, Brain mapping, Neurotransmitters, Adolescence
Abstract: The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents. Additionally, spatial correlation analyses of resilience-related structural similarity network and neurotransmitter distribution maps were conducted to identify molecular adaptations within prefrontal-hippocampal circuits associated with resilience. The results showed that higher resilience levels were correlated with stronger structural similarity between the prefrontal areas (i.e., middle frontal gyrus and orbitofrontal cortex) and hippocampus. Furthermore, the serotonergic neurotransmitter system, which modulates neural oscillations in prefrontal-hippocampal pathways, appears to be associated with resilience. The current findings suggest that structural and molecular adaptations within prefrontal-hippocampal circuits, which are implicated in the suppression of intrusive, unwanted memories, may foster resilience in young people. These insights advance our knowledge of the neurobiological markers of resilience, paving the way for more targeted and effective therapeutic interventions to bolster resilience and mitigate adverse outcomes in developmental populations. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prefrontal-hippocampal pathways underlying adolescent resilience.
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  Data: <searchLink fieldCode="AR" term="%22Wei%2C+Luqing%22">Wei, Luqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Zhengdong%22">Wu, Zhengdong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Qi%22">Xia, Qi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baeken%2C+Chris%22">Baeken, Chris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Guo-Rong%22">Wu, Guo-Rong</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Sep2025, Vol. 34 Issue 9, p2815-2823. 9p.
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  Label: Abstract
  Group: Ab
  Data: The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents. Additionally, spatial correlation analyses of resilience-related structural similarity network and neurotransmitter distribution maps were conducted to identify molecular adaptations within prefrontal-hippocampal circuits associated with resilience. The results showed that higher resilience levels were correlated with stronger structural similarity between the prefrontal areas (i.e., middle frontal gyrus and orbitofrontal cortex) and hippocampus. Furthermore, the serotonergic neurotransmitter system, which modulates neural oscillations in prefrontal-hippocampal pathways, appears to be associated with resilience. The current findings suggest that structural and molecular adaptations within prefrontal-hippocampal circuits, which are implicated in the suppression of intrusive, unwanted memories, may foster resilience in young people. These insights advance our knowledge of the neurobiological markers of resilience, paving the way for more targeted and effective therapeutic interventions to bolster resilience and mitigate adverse outcomes in developmental populations. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=188516207
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        Value: 10.1007/s00787-025-02704-x
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 2815
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      – SubjectFull: Psychological resilience
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
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      – SubjectFull: Research funding
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      – SubjectFull: Physiological adaptation
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      – SubjectFull: Prefrontal cortex
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      – SubjectFull: Neural pathways
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      – SubjectFull: Questionnaires
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      – SubjectFull: Adolescence
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      – TitleFull: Prefrontal-hippocampal pathways underlying adolescent resilience.
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              Text: Sep2025
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