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The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single‐Center Study.

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Title: The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single‐Center Study.
Authors: Zhu, Yuanrun (AUTHOR), Chen, Gengjing (AUTHOR), Huang, Jin (AUTHOR), He, Ping (AUTHOR), Wu, Zhifeng (AUTHOR), Jiang, Chen (AUTHOR), Cumming, Paul (AUTHOR)
Source: Acta Neurologica Scandinavica. 10/10/2025, Vol. 2025, p1-8. 8p.
Subjects: Alcohol drinking, Brain injuries, Postconcussion syndrome, Headache, Disease risk factors, Logistic regression analysis
Abstract: Traumatic brain injury (TBI) is a prevalent neurosurgical emergency that imposes a significant healthcare burden. Even mild TBI can lead to chronic headache. However, the relationship between posttraumatic headache and alcohol use remains unclear. This study is aimed at investigating the association between alcohol consumption and the development of persistent posttraumatic headache following mild TBI. Adult patients with mild TBI, treated between January 2023 and December 2023, were included. Follow‐up interviews were conducted at least 6 months after hospital discharge. Logistic regression analysis was employed to adjust for baseline characteristics and other comorbidities. A total of 207 patients were analyzed, with an overall incidence of persistent posttraumatic headache of 36.2%. The regression analysis revealed an inverse relationship between alcohol consumption and persistent posttraumatic headache (OR: 0.355, 95% CI: 0.175, 0.717) after adjusting for confounding factors. This association remained unchanged after accounting for TBI‐ or headache‐related alcohol avoidance (OR: 0.436, 95% CI: 0.212, 0.897). Female sex emerged as an independent risk factor for persistent posttraumatic headache (OR: 2.206, 95% CI: 1.107, 4.393). Other variables, including age, duration of hospital stay, in‐hospital neurological symptoms, vomiting, sleep disorders, education level, and comorbidities, did not significantly affect the risk of persistent posttraumatic headache in the regression model. In conclusion, alcohol consumption is inversely associated with persistent posttraumatic headache in mild TBI patients. Although TBI‐ or headache‐induced alcohol avoidance provides a plausible explanation for this inverse relationship, it may not fully account for the phenomenon. Female patients are at a higher risk of developing persistent posttraumatic headache after mild TBI. Further studies with low bias are needed to explore this relationship. Medical recommendations regarding alcohol consumption should be provided cautiously, considering the latest evidence, to inform patients with mild TBI about the potential risk of posttraumatic headache. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single‐Center Study.
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  Data: <searchLink fieldCode="AR" term="%22Zhu%2C+Yuanrun%22">Zhu, Yuanrun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Gengjing%22">Chen, Gengjing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Jin%22">Huang, Jin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Ping%22">He, Ping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Zhifeng%22">Wu, Zhifeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Chen%22">Jiang, Chen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cumming%2C+Paul%22">Cumming, Paul</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 10/10/2025, Vol. 2025, p1-8. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Postconcussion+syndrome%22">Postconcussion syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Headache%22">Headache</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Traumatic brain injury (TBI) is a prevalent neurosurgical emergency that imposes a significant healthcare burden. Even mild TBI can lead to chronic headache. However, the relationship between posttraumatic headache and alcohol use remains unclear. This study is aimed at investigating the association between alcohol consumption and the development of persistent posttraumatic headache following mild TBI. Adult patients with mild TBI, treated between January 2023 and December 2023, were included. Follow‐up interviews were conducted at least 6 months after hospital discharge. Logistic regression analysis was employed to adjust for baseline characteristics and other comorbidities. A total of 207 patients were analyzed, with an overall incidence of persistent posttraumatic headache of 36.2%. The regression analysis revealed an inverse relationship between alcohol consumption and persistent posttraumatic headache (OR: 0.355, 95% CI: 0.175, 0.717) after adjusting for confounding factors. This association remained unchanged after accounting for TBI‐ or headache‐related alcohol avoidance (OR: 0.436, 95% CI: 0.212, 0.897). Female sex emerged as an independent risk factor for persistent posttraumatic headache (OR: 2.206, 95% CI: 1.107, 4.393). Other variables, including age, duration of hospital stay, in‐hospital neurological symptoms, vomiting, sleep disorders, education level, and comorbidities, did not significantly affect the risk of persistent posttraumatic headache in the regression model. In conclusion, alcohol consumption is inversely associated with persistent posttraumatic headache in mild TBI patients. Although TBI‐ or headache‐induced alcohol avoidance provides a plausible explanation for this inverse relationship, it may not fully account for the phenomenon. Female patients are at a higher risk of developing persistent posttraumatic headache after mild TBI. Further studies with low bias are needed to explore this relationship. Medical recommendations regarding alcohol consumption should be provided cautiously, considering the latest evidence, to inform patients with mild TBI about the potential risk of posttraumatic headache. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/ane/8359474
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      – SubjectFull: Postconcussion syndrome
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      – SubjectFull: Logistic regression analysis
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      – TitleFull: The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single‐Center Study.
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              Text: 10/10/2025
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