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Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle.

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Title: Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle.
Authors: Gonzalez Utrilla, Mariana (AUTHOR), Chesney, Edward (AUTHOR), Neale, Joanne (AUTHOR), Metrebian, Nicola (AUTHOR), Kalk, Nicola (AUTHOR), Skulberg, Arne Kristian (AUTHOR), Dietze, Paul (AUTHOR), Smith, Martin (AUTHOR), Strang, John (AUTHOR)
Source: Addiction. Nov2025, Vol. 120 Issue 11, p2165-2172. 8p.
Subjects: Drug overdose, Pharmaceutical arithmetic, Combination drug therapy, Drug administration routes, First aid in illness & injury, Emergency medical services, Dose-effect relationship in pharmacology, Patient-centered care, Narcotics, Naloxone, Synthetic drugs
Abstract: The opioid overdose epidemic remains a critical public health crisis. In recent years, synthetic opioids like fentanyl and nitazenes, have driven a sharp rise in deaths. Naloxone, an opioid receptor antagonist, has been established as a key intervention for reversing opioid overdoses and saving lives. However, there remains a critical need to optimize naloxone dosing strategies. This article examines the challenges of both under‐dosing and over‐antagonism in naloxone administration, emphasizing the importance of a tailored approach to overdose management. A 'just the right dose' approach is essential for minimizing the risks of over‐antagonism while still reversing opioid overdose. This involves starting with a modest naloxone dose and carefully titrating it based on the patient's response, considering factors such as opioid type, overdose severity, and opioid tolerance. A tailored approach to naloxone dosing may present challenges for non‐medically trained responders but it can ensure that as many people as possible receive the right dose of naloxone when they need it. Training programs should also emphasize the importance of first aid and supportive care, including airway management and alerting emergency services, as well as careful monitoring of the patient's response. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle.
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  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Nov2025, Vol. 120 Issue 11, p2165-2172. 8p.
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  Data: The opioid overdose epidemic remains a critical public health crisis. In recent years, synthetic opioids like fentanyl and nitazenes, have driven a sharp rise in deaths. Naloxone, an opioid receptor antagonist, has been established as a key intervention for reversing opioid overdoses and saving lives. However, there remains a critical need to optimize naloxone dosing strategies. This article examines the challenges of both under‐dosing and over‐antagonism in naloxone administration, emphasizing the importance of a tailored approach to overdose management. A 'just the right dose' approach is essential for minimizing the risks of over‐antagonism while still reversing opioid overdose. This involves starting with a modest naloxone dose and carefully titrating it based on the patient's response, considering factors such as opioid type, overdose severity, and opioid tolerance. A tailored approach to naloxone dosing may present challenges for non‐medically trained responders but it can ensure that as many people as possible receive the right dose of naloxone when they need it. Training programs should also emphasize the importance of first aid and supportive care, including airway management and alerting emergency services, as well as careful monitoring of the patient's response. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=188720886
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        Value: 10.1111/add.70060
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        Text: English
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        Type: general
      – SubjectFull: Pharmaceutical arithmetic
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      – SubjectFull: Combination drug therapy
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      – SubjectFull: Drug administration routes
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      – SubjectFull: First aid in illness & injury
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      – SubjectFull: Narcotics
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      – SubjectFull: Naloxone
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      – SubjectFull: Synthetic drugs
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              Text: Nov2025
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