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Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.

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Title: Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.
Authors: Numbers, Katya (AUTHOR), Samtani, Suraj (AUTHOR), Hanewald, Katja (AUTHOR), Cheung, Jared (AUTHOR), Sachdev, Perminder S. (AUTHOR), Brodaty, Henry (AUTHOR)
Source: International Journal of Geriatric Psychiatry. Oct2025, Vol. 40 Issue 10, p1-10. 10p.
Subjects: Diagnosis of dementia, Cognition disorders diagnosis, Psychological aspects of aging, Mortality, Sense organs, Vital signs, Predictive tests, Consensus (Social sciences), Pearson correlation (Statistics), Health status indicators, Research funding, Questionnaires, Frail elderly, Structural equation modeling, Descriptive statistics, Longitudinal method, Physical fitness, Neuropsychological tests, Dementia, Psychological tests, Survival analysis (Biometry), Factor analysis, Data analysis software, Proportional hazards models, Human locomotion
Geographic Terms: Australia
Abstract: Background: Intrinsic Capacity (IC) is a developing concept focussed on promoting healthy ageing by maintaining functional abilities. It has been proposed as a better predictor of outcomes like dementia and mortality, compared to traditional frailty measures that focus on deficits. This study aims to replicate the five‐factor structure of IC among older adults in Australia and to evaluate its effectiveness in predicting long‐term health outcomes, in comparison with existing frailty measures. Methods: IC scores were computed for 400 older adults aged 70 to 90 participating in the Sydney Memory and Ageing Study (MAS). Structural equation modelling, including second‐order confirmatory analysis, was used to compute the five IC domains. Cox proportional hazard models were used to compare the predictive value of the second‐order IC factor with the Frailty Phenotype and Frailty Index for dementia over 10 years and mortality over 12 years. Results: Factor loadings for the IC structure yielded five subgroups (cognitive function, psychological health, locomotive ability, sensory function, vital function) with one global factor. The structure had good fit (SRMR = 0.054, GFI = 0.966). IC was associated with lower hazard (risk) of dementia (HR = 0.567, p < 0.001) over 10‐year and lower hazard of mortality (HR = 0.649, p < 0.001) over 12‐year, controlling for age, sex, and education. Finally, IC explained additional variance beyond the Frailty Phenotype when predicting both incident dementia and mortality risk. Compared with the Frailty Index, IC contributed additional variance for dementia risk but not for mortality. Conclusion: Evaluation of a person's IC at baseline explains additional variance compared to traditional frailty measures when predicting the risk of future negative health outcomes such as dementia incidence and mortality. Key Points: The World Health Organisation proposed Intrinsic Capacity as a more holistic measure of capacity than purely disability or frailty scales.This study replicated the five factors of the Intrinsic Capacity measure in an Australian community sample aged 70–90 years who were dementia‐free at baseline.Intrinsic capacity proved to be superior to frailty measures in predicting risk of dementia over 10 years of follow up and mortality over 12 years of follow up. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Numbers%2C+Katya%22&quot;&gt;Numbers, Katya&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Samtani%2C+Suraj%22&quot;&gt;Samtani, Suraj&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hanewald%2C+Katja%22&quot;&gt;Hanewald, Katja&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cheung%2C+Jared%22&quot;&gt;Cheung, Jared&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sachdev%2C+Perminder+S%2E%22&quot;&gt;Sachdev, Perminder S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brodaty%2C+Henry%22&quot;&gt;Brodaty, Henry&lt;/searchLink&gt; (AUTHOR)
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  Data: Background: Intrinsic Capacity (IC) is a developing concept focussed on promoting healthy ageing by maintaining functional abilities. It has been proposed as a better predictor of outcomes like dementia and mortality, compared to traditional frailty measures that focus on deficits. This study aims to replicate the five‐factor structure of IC among older adults in Australia and to evaluate its effectiveness in predicting long‐term health outcomes, in comparison with existing frailty measures. Methods: IC scores were computed for 400 older adults aged 70 to 90 participating in the Sydney Memory and Ageing Study (MAS). Structural equation modelling, including second‐order confirmatory analysis, was used to compute the five IC domains. Cox proportional hazard models were used to compare the predictive value of the second‐order IC factor with the Frailty Phenotype and Frailty Index for dementia over 10 years and mortality over 12 years. Results: Factor loadings for the IC structure yielded five subgroups (cognitive function, psychological health, locomotive ability, sensory function, vital function) with one global factor. The structure had good fit (SRMR = 0.054, GFI = 0.966). IC was associated with lower hazard (risk) of dementia (HR = 0.567, p &lt; 0.001) over 10‐year and lower hazard of mortality (HR = 0.649, p &lt; 0.001) over 12‐year, controlling for age, sex, and education. Finally, IC explained additional variance beyond the Frailty Phenotype when predicting both incident dementia and mortality risk. Compared with the Frailty Index, IC contributed additional variance for dementia risk but not for mortality. Conclusion: Evaluation of a person&#39;s IC at baseline explains additional variance compared to traditional frailty measures when predicting the risk of future negative health outcomes such as dementia incidence and mortality. Key Points: The World Health Organisation proposed Intrinsic Capacity as a more holistic measure of capacity than purely disability or frailty scales.This study replicated the five factors of the Intrinsic Capacity measure in an Australian community sample aged 70–90 years who were dementia‐free at baseline.Intrinsic capacity proved to be superior to frailty measures in predicting risk of dementia over 10 years of follow up and mortality over 12 years of follow up. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: &lt;i&gt;Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/gps.70156
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        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 1
    Subjects:
      – SubjectFull: Diagnosis of dementia
        Type: general
      – SubjectFull: Cognition disorders diagnosis
        Type: general
      – SubjectFull: Psychological aspects of aging
        Type: general
      – SubjectFull: Mortality
        Type: general
      – SubjectFull: Sense organs
        Type: general
      – SubjectFull: Vital signs
        Type: general
      – SubjectFull: Predictive tests
        Type: general
      – SubjectFull: Consensus (Social sciences)
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Frail elderly
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      – SubjectFull: Structural equation modeling
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Physical fitness
        Type: general
      – SubjectFull: Neuropsychological tests
        Type: general
      – SubjectFull: Dementia
        Type: general
      – SubjectFull: Psychological tests
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      – SubjectFull: Survival analysis (Biometry)
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      – SubjectFull: Proportional hazards models
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      – SubjectFull: Human locomotion
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      – SubjectFull: Australia
        Type: general
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      – TitleFull: Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.
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            – D: 01
              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
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