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Nonmotor Symptoms Reduce Quality of Life in Parkinson′s Disease Depending on Disease Stage and Age at Onset.

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Title: Nonmotor Symptoms Reduce Quality of Life in Parkinson′s Disease Depending on Disease Stage and Age at Onset.
Authors: Bovenzi, Roberta (AUTHOR), Conti, Matteo (AUTHOR), Chiurchiù, Valerio (AUTHOR), De Franco, Valentino (AUTHOR), Di Pucchio, Alessandra (AUTHOR), Pierantozzi, Mariangela (AUTHOR), Schirinzi, Tommaso (AUTHOR), Cerroni, Rocco (AUTHOR), Stefani, Alessandro (AUTHOR), Mercuri, Nicola Biagio (AUTHOR), Liguori, Claudio (AUTHOR), Fee, Dominic B. (AUTHOR)
Source: Acta Neurologica Scandinavica. 10/27/2025, Vol. 2025, p1-9. 9p.
Subjects: Quality of life, Parkinson's disease, Age of onset, Disease progression, Dopamine agents, Sleep interruptions, Symptoms, Physical mobility
Abstract: In this observational study, which presents a secondary analysis related to a previously published work from our group, we aimed to examine the impact of nonmotor symptom (NMS) burden on HR‐QoL in 154 outpatients with Parkinson′s disease (PD), ranging from mild to moderate‐advanced disease stages, with a specific focus on motor disease progression and age at onset (AAO). To this purpose, NMS burden was measured using the NMS scale (NMSS), overall HR‐QoL using the Parkinson′s Disease Questionnaire‐39 (PDQ‐39), and sleep disturbances using the Parkinson′s Disease Sleep Scale‐2nd version (PDSS‐2). The scores of the three scales were correlated with motor impairment and the amount of dopaminergic therapy. Furthermore, NMSS, PDQ‐39, and PDSS‐2 scores were compared between early onset PD (EOPD, AAO ≤ 50) and late‐onset PD (LOPD, AAO > 50), as well as between "poor sleepers" and "good sleepers" based on the validated PDSS‐2 cutoff of 18/60. We found that total NMSS, PDSS‐2, and PDQ‐39 scores significantly increased with advancing disease stage. EOPD patients had lower NMSS and PDSS‐2 global scores compared to LOPD patients, despite the latter having longer disease duration and similar PDQ‐39 scores. The NMSS global score correlated with each single domain of the PDQ‐39, with the strongest associations observed in the "mobility," "activity of daily living," and "cognition" domains. Over one‐third of patients were classified as "poor sleepers" (PDSS‐2 ≥ 18) and exhibited higher NMSS and PDQ‐39 total scores compared to "good sleepers." In conclusion, this study enlightens the increasing impact of NMS and sleep disturbances on patients′ HR‐QoL with disease progression and across different AAO, underscoring the need to address such modifiable factors to alleviate the burden of the disease. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Nonmotor Symptoms Reduce Quality of Life in Parkinson′s Disease Depending on Disease Stage and Age at Onset.
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  Data: <searchLink fieldCode="AR" term="%22Bovenzi%2C+Roberta%22">Bovenzi, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conti%2C+Matteo%22">Conti, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiurchiù%2C+Valerio%22">Chiurchiù, Valerio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Franco%2C+Valentino%22">De Franco, Valentino</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Pucchio%2C+Alessandra%22">Di Pucchio, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierantozzi%2C+Mariangela%22">Pierantozzi, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schirinzi%2C+Tommaso%22">Schirinzi, Tommaso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cerroni%2C+Rocco%22">Cerroni, Rocco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefani%2C+Alessandro%22">Stefani, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercuri%2C+Nicola+Biagio%22">Mercuri, Nicola Biagio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liguori%2C+Claudio%22">Liguori, Claudio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fee%2C+Dominic+B%2E%22">Fee, Dominic B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 10/27/2025, Vol. 2025, p1-9. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Age+of+onset%22">Age of onset</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+agents%22">Dopamine agents</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+interruptions%22">Sleep interruptions</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+mobility%22">Physical mobility</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In this observational study, which presents a secondary analysis related to a previously published work from our group, we aimed to examine the impact of nonmotor symptom (NMS) burden on HR‐QoL in 154 outpatients with Parkinson′s disease (PD), ranging from mild to moderate‐advanced disease stages, with a specific focus on motor disease progression and age at onset (AAO). To this purpose, NMS burden was measured using the NMS scale (NMSS), overall HR‐QoL using the Parkinson′s Disease Questionnaire‐39 (PDQ‐39), and sleep disturbances using the Parkinson′s Disease Sleep Scale‐2nd version (PDSS‐2). The scores of the three scales were correlated with motor impairment and the amount of dopaminergic therapy. Furthermore, NMSS, PDQ‐39, and PDSS‐2 scores were compared between early onset PD (EOPD, AAO ≤ 50) and late‐onset PD (LOPD, AAO > 50), as well as between "poor sleepers" and "good sleepers" based on the validated PDSS‐2 cutoff of 18/60. We found that total NMSS, PDSS‐2, and PDQ‐39 scores significantly increased with advancing disease stage. EOPD patients had lower NMSS and PDSS‐2 global scores compared to LOPD patients, despite the latter having longer disease duration and similar PDQ‐39 scores. The NMSS global score correlated with each single domain of the PDQ‐39, with the strongest associations observed in the "mobility," "activity of daily living," and "cognition" domains. Over one‐third of patients were classified as "poor sleepers" (PDSS‐2 ≥ 18) and exhibited higher NMSS and PDQ‐39 total scores compared to "good sleepers." In conclusion, this study enlightens the increasing impact of NMS and sleep disturbances on patients′ HR‐QoL with disease progression and across different AAO, underscoring the need to address such modifiable factors to alleviate the burden of the disease. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1155/ane/2145092
    Languages:
      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 1
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      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Age of onset
        Type: general
      – SubjectFull: Disease progression
        Type: general
      – SubjectFull: Dopamine agents
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      – SubjectFull: Sleep interruptions
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      – SubjectFull: Symptoms
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      – SubjectFull: Physical mobility
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              Text: 10/27/2025
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