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Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study.

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Title: Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study.
Authors: Lin, Yu-Han (AUTHOR), Tsai, Shih-Jen (AUTHOR), Bai, Ya-Mei (AUTHOR), Chen, Tzeng-Ji (AUTHOR), Chen, Mu-Hong (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Nov2025, Vol. 55 Issue 11, p4009-4017. 9p.
Subjects: Autism risk factors, Risk factors of attention-deficit hyperactivity disorder, Risk assessment, Pearson correlation (Statistics), Child psychopathology, Tic disorders, Research funding, Children of parents with disabilities, Mothers, Sex distribution, Socioeconomic factors, Parent-child relationships, Retrospective studies, Descriptive statistics, Chi-squared test, Age distribution, Longitudinal method, Odds ratio, Developmental disabilities, Fathers, Medical records, Acquisition of data, Psychology of parents, Comparative studies, Data analysis software, Confidence intervals, Asperger's syndrome, Psychosocial factors, Mental depression, Regression analysis, Disease risk factors
Geographic Terms: Taiwan
Abstract: Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Nov2025, Vol. 55 Issue 11, p4009-4017. 9p.
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  Data: Studies have reported inconsistent results regarding associations between parental depression and offspring neurodevelopmental disorders, such as developmental delay and autism spectrum disorder (ASD). In all, 7,593 children who were born between 1996 and 2010 in Taiwan and had at least one parent with major depressive disorder and 75,930 birth-year- and sex-matched children of parents without major depressive disorder were followed from 1996 or time of birth to the end of 2011. Intergroup differences in neurodevelopmental conditions—including ASD, attention-deficit hyperactivity disorder (ADHD), tic disorder, developmental delay, and intellectual disability (ID)—were assessed. Compared with the children in the control group, the children of parents with major depression were more likely [hazard ratio (HR), 95% confidence interval (CI)] to develop ADHD (1.98, 1.80–2.18), ASD (1.52, 1.16–1.94), tic disorder (1.40, 1.08–1.81), developmental delay (1.32, 1.20–1.45), and ID (1.26, 1.02–1.55). Parental depression was associated with offspring neurodevelopmental disorders, specifically ASD, ADHD, developmental delay, ID, and tic disorder. Therefore, clinicians should closely monitor the neurodevelopmental conditions of children of parents with depression. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189005205
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      – Type: doi
        Value: 10.1007/s10803-024-06502-3
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      – Code: eng
        Text: English
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        PageCount: 9
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    Subjects:
      – SubjectFull: Autism risk factors
        Type: general
      – SubjectFull: Risk factors of attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Child psychopathology
        Type: general
      – SubjectFull: Tic disorders
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Children of parents with disabilities
        Type: general
      – SubjectFull: Mothers
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Socioeconomic factors
        Type: general
      – SubjectFull: Parent-child relationships
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      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Longitudinal method
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      – SubjectFull: Data analysis software
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      – SubjectFull: Disease risk factors
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      – SubjectFull: Taiwan
        Type: general
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      – TitleFull: Risk of Neurodevelopmental Disorders in Offspring of Parents with Major Depressive Disorder: A Birth Cohort Study.
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