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Neuritis Ossificans in the Facial Nerve: A Case Report.

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Title: Neuritis Ossificans in the Facial Nerve: A Case Report.
Authors: Snyder, Alyssa J. (AUTHOR), Ji, Keven Seung Yong (AUTHOR), Wood, Matthew D. (AUTHOR), Loyo Li, Myriam (AUTHOR)
Source: Annals of Otology, Rhinology & Laryngology. Dec2025, Vol. 134 Issue 12, p937-941. 5p.
Subjects: Physical diagnosis, Biopsy, Differential diagnosis, Neuritis, Magnetic resonance imaging, Metaplastic ossification, Facial nerve, Facial paralysis, Histology
Abstract: Objectives: Neuritis ossificans is a rare condition involving heterotopic ossification of nerves, usually affecting major peripheral nerves. Two cases involving cranial nerves are documented, with none affecting the facial nerve. The aim of this report is to present the first documented case of neuritis ossificans involving the facial nerve (CN VII), with a review of clinical, radiologic, and histologic findings. Methods: An 88-year-old male with a history of radiation therapy for right ear basal cell carcinoma presented with 18 months of progressive right-sided facial weakness, resulting in complete flaccid paralysis. MRI revealed subtle enhancement of the right trigeminal nerve. He underwent facial nerve exploration. Intraoperatively, a large segment of the facial nerve appeared grossly abnormal, and biopsy revealed small rounded and linear mineral deposits with concentric internal structuring, lined focally by collections of histiocytes. This is a single case report with literature review. Results: Histopathology confirmed the absence of malignancy and identified mineral deposits consistent with neuritis ossificans. Given the extensive nerve damage, nerve transfers were not feasible, leading to the decision to proceed with static suspension surgery. Conclusion: This case is the first known instance of neuritis ossificans affecting the facial nerve, emphasizing the diagnostic challenge in this rare condition. Histopathological evaluation was critical for diagnosis, informing the decision for static suspension surgery due to irreversible paralysis. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Neuritis Ossificans in the Facial Nerve: A Case Report.
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  Data: <searchLink fieldCode="AR" term="%22Snyder%2C+Alyssa+J%2E%22">Snyder, Alyssa J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Keven+Seung+Yong%22">Ji, Keven Seung Yong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wood%2C+Matthew+D%2E%22">Wood, Matthew D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Loyo+Li%2C+Myriam%22">Loyo Li, Myriam</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Dec2025, Vol. 134 Issue 12, p937-941. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Physical+diagnosis%22">Physical diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Differential+diagnosis%22">Differential diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Neuritis%22">Neuritis</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Metaplastic+ossification%22">Metaplastic ossification</searchLink><br /><searchLink fieldCode="DE" term="%22Facial+nerve%22">Facial nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Facial+paralysis%22">Facial paralysis</searchLink><br /><searchLink fieldCode="DE" term="%22Histology%22">Histology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Neuritis ossificans is a rare condition involving heterotopic ossification of nerves, usually affecting major peripheral nerves. Two cases involving cranial nerves are documented, with none affecting the facial nerve. The aim of this report is to present the first documented case of neuritis ossificans involving the facial nerve (CN VII), with a review of clinical, radiologic, and histologic findings. Methods: An 88-year-old male with a history of radiation therapy for right ear basal cell carcinoma presented with 18 months of progressive right-sided facial weakness, resulting in complete flaccid paralysis. MRI revealed subtle enhancement of the right trigeminal nerve. He underwent facial nerve exploration. Intraoperatively, a large segment of the facial nerve appeared grossly abnormal, and biopsy revealed small rounded and linear mineral deposits with concentric internal structuring, lined focally by collections of histiocytes. This is a single case report with literature review. Results: Histopathology confirmed the absence of malignancy and identified mineral deposits consistent with neuritis ossificans. Given the extensive nerve damage, nerve transfers were not feasible, leading to the decision to proceed with static suspension surgery. Conclusion: This case is the first known instance of neuritis ossificans affecting the facial nerve, emphasizing the diagnostic challenge in this rare condition. Histopathological evaluation was critical for diagnosis, informing the decision for static suspension surgery due to irreversible paralysis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1177/00034894251353576
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        Text: English
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      – SubjectFull: Physical diagnosis
        Type: general
      – SubjectFull: Biopsy
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      – SubjectFull: Differential diagnosis
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      – SubjectFull: Neuritis
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      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Metaplastic ossification
        Type: general
      – SubjectFull: Facial nerve
        Type: general
      – SubjectFull: Facial paralysis
        Type: general
      – SubjectFull: Histology
        Type: general
    Titles:
      – TitleFull: Neuritis Ossificans in the Facial Nerve: A Case Report.
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              M: 12
              Text: Dec2025
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              Y: 2025
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