The synergistic impact of probiotics and dietary fiber on constipation management in chlorpromazine-induced schizophrenia patients: exploring the modulation of intestinal microbiota and neurotrophic factors.
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| Title: | The synergistic impact of probiotics and dietary fiber on constipation management in chlorpromazine-induced schizophrenia patients: exploring the modulation of intestinal microbiota and neurotrophic factors. |
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| Authors: | Yang, Ningbo (AUTHOR), Li, Jie (AUTHOR), Hu, Hongxia (AUTHOR), Shi, Shaoli (AUTHOR), Li, Yanhong (AUTHOR), Sun, Wenwen (AUTHOR) |
| Source: | International Journal of Neuroscience. Nov2025, Vol. 135 Issue 11, p1186-1192. 7p. |
| Subjects: | Probiotics, Dietary fiber, Gut microbiota, Constipation, Treatment effectiveness, Schizophrenia, Neurotrophins, Quality of life |
| Abstract: | Objective: To explore the improvement effect of probiotics combined with dietary fiber on constipation in patients with schizophrenia. Methods: To compare the improvement scores of constipation, constipation symptoms, quality of life, neurotrophic factors-related indicators, and clinical efficacy between the two groups. Results: There was no statistically significant difference in Cleveland Constipation Scoring System (CCS) scores in the control group before and after treatment (p > 0.05), while the CCS scores in the observation group decreased significantly after treatment (p < 0.05); Patient Assessment of Constipation Symptoms scores significantly decreased in the observation group compared to the control group (p < 0.05), with no significant difference in Patient Assessment of Constipation Quality of Life scores between the two groups pre- and post-treatment; Neuron-specific enolase levels decreased significantly in both groups post-treatment, while brain-derived neurotrophic factor, neuregulin-1, and nerve growth factor levels increased significantly, with a more pronounced rise in the observation group (p < 0.05). Additionally, the total effective rate of clinical treatment in the observation group was higher than that in the control group (p < 0.05). Conclusion: Probiotics combined with dietary fiber can improve constipation symptoms in patients with schizophrenia accompanied by constipation, effectively maintain the balance of intestinal microbiota, and improve the quality of life of patients. Additionally, levels of neurotrophic factors associated with bowel function and neurological health increased significantly, with a higher total effective rate of clinical treatment observed in the probiotics and dietary fiber group. These findings suggest the potential efficacy of probiotics and dietary fiber in managing constipation in this patient population. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 189024991 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The synergistic impact of probiotics and dietary fiber on constipation management in chlorpromazine-induced schizophrenia patients: exploring the modulation of intestinal microbiota and neurotrophic factors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yang%2C+Ningbo%22">Yang, Ningbo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Jie%22">Li, Jie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Hongxia%22">Hu, Hongxia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Shaoli%22">Shi, Shaoli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yanhong%22">Li, Yanhong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Wenwen%22">Sun, Wenwen</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Nov2025, Vol. 135 Issue 11, p1186-1192. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Probiotics%22">Probiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Dietary+fiber%22">Dietary fiber</searchLink><br /><searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Constipation%22">Constipation</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotrophins%22">Neurotrophins</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To explore the improvement effect of probiotics combined with dietary fiber on constipation in patients with schizophrenia. Methods: To compare the improvement scores of constipation, constipation symptoms, quality of life, neurotrophic factors-related indicators, and clinical efficacy between the two groups. Results: There was no statistically significant difference in Cleveland Constipation Scoring System (CCS) scores in the control group before and after treatment (p > 0.05), while the CCS scores in the observation group decreased significantly after treatment (p < 0.05); Patient Assessment of Constipation Symptoms scores significantly decreased in the observation group compared to the control group (p < 0.05), with no significant difference in Patient Assessment of Constipation Quality of Life scores between the two groups pre- and post-treatment; Neuron-specific enolase levels decreased significantly in both groups post-treatment, while brain-derived neurotrophic factor, neuregulin-1, and nerve growth factor levels increased significantly, with a more pronounced rise in the observation group (p < 0.05). Additionally, the total effective rate of clinical treatment in the observation group was higher than that in the control group (p < 0.05). Conclusion: Probiotics combined with dietary fiber can improve constipation symptoms in patients with schizophrenia accompanied by constipation, effectively maintain the balance of intestinal microbiota, and improve the quality of life of patients. Additionally, levels of neurotrophic factors associated with bowel function and neurological health increased significantly, with a higher total effective rate of clinical treatment observed in the probiotics and dietary fiber group. These findings suggest the potential efficacy of probiotics and dietary fiber in managing constipation in this patient population. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207454.2024.2352023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1186 Subjects: – SubjectFull: Probiotics Type: general – SubjectFull: Dietary fiber Type: general – SubjectFull: Gut microbiota Type: general – SubjectFull: Constipation Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Neurotrophins Type: general – SubjectFull: Quality of life Type: general Titles: – TitleFull: The synergistic impact of probiotics and dietary fiber on constipation management in chlorpromazine-induced schizophrenia patients: exploring the modulation of intestinal microbiota and neurotrophic factors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yang, Ningbo – PersonEntity: Name: NameFull: Li, Jie – PersonEntity: Name: NameFull: Hu, Hongxia – PersonEntity: Name: NameFull: Shi, Shaoli – PersonEntity: Name: NameFull: Li, Yanhong – PersonEntity: Name: NameFull: Sun, Wenwen IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 135 – Type: issue Value: 11 Titles: – TitleFull: International Journal of Neuroscience Type: main |
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