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Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose.

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Title: Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose.
Authors: Flores-Rabasa, R. (AUTHOR), González-Almazán, J. A. (AUTHOR), Cortés- Contreras, Ana Paula (AUTHOR), Méndez-García, L. A. (AUTHOR), Velasco, F. (AUTHOR), Navarro-Olvera, J. L. (AUTHOR), Aguado-Carrillo, G. (AUTHOR), Benítez-Gasca, A. (AUTHOR), Gómez-Apo, E. (AUTHOR), Carrillo-Ruiz, J. D. (AUTHOR)
Source: International Journal of Neuroscience. Nov2025, Vol. 135 Issue 11, p1265-1272. 8p.
Subjects: Pituitary tumors, Blood sugar, Surgery, Magnetic resonance imaging, Tumor growth, Medical research
Abstract: Objectives: This clinical, analytical, retro-prospective, auto-controlled, not randomized, and not blinded study, aimed to investigate the association of changes in the serum glucose levels with the pre-and-post changes in the size tumor in mm3 in the Non-Functional pituitary adenomas. Methods: Pre-and post-surgical MRI, as well as the measurements in the serum glucose levels and immunohistochemical techniques were performed in all the patients in the study, with a mean followed-up until 208.57 days. A comparison was made between the reductions in tumor size of hormonally active pituitary adenomas (HSPAs) vs NFPAs. Results: Seventy-four patients were included in this study, of whom, 46 were NFPAs. The decrease in the NFPAs tumor size after surgery was statistically significant (P ≤ 0.0001). The Mean of the differences of both type of tumors in mm3 were −9552 ± 10287. Pre-surgery, the mean of the HSPAs were 8.923 ± 2.078; and the NFPAs were 14.161 ± 1.912. The differences in the tumor size were statistically significant (p = 0.039). Post-surgical, the mean of the HSPAs were 2.079 ± 971, with a (p = 0.14): and the NFPAs were 4.609 ± 1.205. After surgery of the NFPAs, most of the patients-maintained serum levels ≤ 100 mg/dL, with a statistical significance (P ≤ 0.0003). Conclusion: This study demonstrates for the first time the correlation between the presence of pre-and post- surgical changes in the NFPAs, with modifications in the levels of serum glucose, and the comparison, pre- and post-surgical between the tumor size of HSPAs and NFPAs. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose.
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  Data: <searchLink fieldCode="AR" term="%22Flores-Rabasa%2C+R%2E%22">Flores-Rabasa, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22González-Almazán%2C+J%2E+A%2E%22">González-Almazán, J. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cortés-+Contreras%2C+Ana+Paula%22">Cortés- Contreras, Ana Paula</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Méndez-García%2C+L%2E+A%2E%22">Méndez-García, L. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Velasco%2C+F%2E%22">Velasco, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Navarro-Olvera%2C+J%2E+L%2E%22">Navarro-Olvera, J. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aguado-Carrillo%2C+G%2E%22">Aguado-Carrillo, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benítez-Gasca%2C+A%2E%22">Benítez-Gasca, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gómez-Apo%2C+E%2E%22">Gómez-Apo, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carrillo-Ruiz%2C+J%2E+D%2E%22">Carrillo-Ruiz, J. D.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Nov2025, Vol. 135 Issue 11, p1265-1272. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Pituitary+tumors%22">Pituitary tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar%22">Blood sugar</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+growth%22">Tumor growth</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This clinical, analytical, retro-prospective, auto-controlled, not randomized, and not blinded study, aimed to investigate the association of changes in the serum glucose levels with the pre-and-post changes in the size tumor in mm3 in the Non-Functional pituitary adenomas. Methods: Pre-and post-surgical MRI, as well as the measurements in the serum glucose levels and immunohistochemical techniques were performed in all the patients in the study, with a mean followed-up until 208.57 days. A comparison was made between the reductions in tumor size of hormonally active pituitary adenomas (HSPAs) vs NFPAs. Results: Seventy-four patients were included in this study, of whom, 46 were NFPAs. The decrease in the NFPAs tumor size after surgery was statistically significant (P ≤ 0.0001). The Mean of the differences of both type of tumors in mm3 were −9552 ± 10287. Pre-surgery, the mean of the HSPAs were 8.923 ± 2.078; and the NFPAs were 14.161 ± 1.912. The differences in the tumor size were statistically significant (p = 0.039). Post-surgical, the mean of the HSPAs were 2.079 ± 971, with a (p = 0.14): and the NFPAs were 4.609 ± 1.205. After surgery of the NFPAs, most of the patients-maintained serum levels ≤ 100 mg/dL, with a statistical significance (P ≤ 0.0003). Conclusion: This study demonstrates for the first time the correlation between the presence of pre-and post- surgical changes in the NFPAs, with modifications in the levels of serum glucose, and the comparison, pre- and post-surgical between the tumor size of HSPAs and NFPAs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00207454.2024.2352780
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1265
    Subjects:
      – SubjectFull: Pituitary tumors
        Type: general
      – SubjectFull: Blood sugar
        Type: general
      – SubjectFull: Surgery
        Type: general
      – SubjectFull: Magnetic resonance imaging
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              Text: Nov2025
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