Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose.
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| Title: | Pre-and post-surgical non-functional pituitary adenomas and their relationship with high levels of serum glucose. |
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| Authors: | Flores-Rabasa, R. (AUTHOR), González-Almazán, J. A. (AUTHOR), Cortés- Contreras, Ana Paula (AUTHOR), Méndez-García, L. A. (AUTHOR), Velasco, F. (AUTHOR), Navarro-Olvera, J. L. (AUTHOR), Aguado-Carrillo, G. (AUTHOR), Benítez-Gasca, A. (AUTHOR), Gómez-Apo, E. (AUTHOR), Carrillo-Ruiz, J. D. (AUTHOR) |
| Source: | International Journal of Neuroscience. Nov2025, Vol. 135 Issue 11, p1265-1272. 8p. |
| Subjects: | Pituitary tumors, Blood sugar, Surgery, Magnetic resonance imaging, Tumor growth, Medical research |
| Abstract: | Objectives: This clinical, analytical, retro-prospective, auto-controlled, not randomized, and not blinded study, aimed to investigate the association of changes in the serum glucose levels with the pre-and-post changes in the size tumor in mm3 in the Non-Functional pituitary adenomas. Methods: Pre-and post-surgical MRI, as well as the measurements in the serum glucose levels and immunohistochemical techniques were performed in all the patients in the study, with a mean followed-up until 208.57 days. A comparison was made between the reductions in tumor size of hormonally active pituitary adenomas (HSPAs) vs NFPAs. Results: Seventy-four patients were included in this study, of whom, 46 were NFPAs. The decrease in the NFPAs tumor size after surgery was statistically significant (P ≤ 0.0001). The Mean of the differences of both type of tumors in mm3 were −9552 ± 10287. Pre-surgery, the mean of the HSPAs were 8.923 ± 2.078; and the NFPAs were 14.161 ± 1.912. The differences in the tumor size were statistically significant (p = 0.039). Post-surgical, the mean of the HSPAs were 2.079 ± 971, with a (p = 0.14): and the NFPAs were 4.609 ± 1.205. After surgery of the NFPAs, most of the patients-maintained serum levels ≤ 100 mg/dL, with a statistical significance (P ≤ 0.0003). Conclusion: This study demonstrates for the first time the correlation between the presence of pre-and post- surgical changes in the NFPAs, with modifications in the levels of serum glucose, and the comparison, pre- and post-surgical between the tumor size of HSPAs and NFPAs. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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