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The need for a global effort to attend to human neural organoid and assembloid research.

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Title: The need for a global effort to attend to human neural organoid and assembloid research.
Authors: Pașca, Sergiu P. (AUTHOR), Arlotta, Paola (AUTHOR), Campbell, Philip (AUTHOR), Charo, Alta (AUTHOR), Evans, John H. (AUTHOR), Farahany, Nita (AUTHOR), Gage, Fred H. (AUTHOR), Godfrey-Smith, Peter (AUTHOR), Hyun, Insoo (AUTHOR), Kriegstein, Arnold R. (AUTHOR), Melloni, Lucia (AUTHOR), Ming, Guo-Li (AUTHOR), Moreno, Jonathan D. (AUTHOR), Sugarman, Jeremy (AUTHOR), Temple, Sally (AUTHOR), Testa, Giuseppe (AUTHOR), Greely, Henry T. (AUTHOR)
Source: Science. 11/6/2025, Vol. 390 Issue 6773, p574-577. 4p.
Subjects: Organoids, Research ethics, International cooperation, Transplantation of organs, tissues, etc., International organization, Policy analysis, Scientific development, Scientific models
Abstract: Human neural organoid and assembloid research, unknown until a little more than a decade ago, has recently exploded. The amount of research, the types of organoids and assembloids, and the scope of the work have expanded markedly. Although some of the ethical and social questions that arise have been previously discussed, these issues continue to grow and become more pressing. In such a fast-moving field, any conclusions will be challenged by new developments. We argue that there is a crucial need for a continuing international process to watch, and to guide, the progress of this field. Whether operationalized through existing organizations or a new one, this process would collect and disseminate evolving information about research involving human neural organoids, assembloids, and their transplantation into nonhuman animals; promote discussion and engagement with associated ethics and policy issues among researchers and the public; and offer guidance when needed. [ABSTRACT FROM AUTHOR]
Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The need for a global effort to attend to human neural organoid and assembloid research.
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  Data: <searchLink fieldCode="AR" term="%22Pașca%2C+Sergiu+P%2E%22">Pașca, Sergiu P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arlotta%2C+Paola%22">Arlotta, Paola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campbell%2C+Philip%22">Campbell, Philip</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Charo%2C+Alta%22">Charo, Alta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Evans%2C+John+H%2E%22">Evans, John H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farahany%2C+Nita%22">Farahany, Nita</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gage%2C+Fred+H%2E%22">Gage, Fred H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Godfrey-Smith%2C+Peter%22">Godfrey-Smith, Peter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hyun%2C+Insoo%22">Hyun, Insoo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kriegstein%2C+Arnold+R%2E%22">Kriegstein, Arnold R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Melloni%2C+Lucia%22">Melloni, Lucia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ming%2C+Guo-Li%22">Ming, Guo-Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreno%2C+Jonathan+D%2E%22">Moreno, Jonathan D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugarman%2C+Jeremy%22">Sugarman, Jeremy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Temple%2C+Sally%22">Temple, Sally</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Testa%2C+Giuseppe%22">Testa, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greely%2C+Henry+T%2E%22">Greely, Henry T.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Science%22">Science</searchLink>. 11/6/2025, Vol. 390 Issue 6773, p574-577. 4p.
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  Data: Human neural organoid and assembloid research, unknown until a little more than a decade ago, has recently exploded. The amount of research, the types of organoids and assembloids, and the scope of the work have expanded markedly. Although some of the ethical and social questions that arise have been previously discussed, these issues continue to grow and become more pressing. In such a fast-moving field, any conclusions will be challenged by new developments. We argue that there is a crucial need for a continuing international process to watch, and to guide, the progress of this field. Whether operationalized through existing organizations or a new one, this process would collect and disseminate evolving information about research involving human neural organoids, assembloids, and their transplantation into nonhuman animals; promote discussion and engagement with associated ethics and policy issues among researchers and the public; and offer guidance when needed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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