View in EDS HTML Full Text PDF Full Text

Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.

Saved in:
Bibliographic Details
Title: Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.
Authors: Jourquin, Jérôme (AUTHOR), Tremblay, Evelyne (AUTHOR), Bernard, Anne (AUTHOR), Charton, Gérard (AUTHOR), Chaillan, Franck A. (AUTHOR), Marchetti, Evelyne (AUTHOR), Roman, François S. (AUTHOR), Soloway, Paul D. (AUTHOR), Dive, Vincent (AUTHOR), Yiotakis, Athanasios (AUTHOR), Khrestchatisky, Michel (AUTHOR), Rivera, Santiago (AUTHOR)
Source: European Journal of Neuroscience. Nov2005, Vol. 22 Issue 10, p2569-2578. 10p. 1 Black and White Photograph, 5 Graphs.
Subjects: Metalloproteins, Neuroplasticity, Learning, Memory, Neural transmission, Neural circuitry, Neurophysiology
Abstract: The tissue inhibitor of metalloproteinases-1 (TIMP-1) belongs to a family of multifunctional proteins that inhibit matrix metalloproteinases (MMPs), but also regulate cell growth, proliferation, migration and apoptosis in non-nervous tissues. We had previously reported that kainate (KA)-mediated excitotoxic seizures induce the expression of TIMP-1 in resistant neurons and reactive astrocytes of the rat CNS, but the functional implications of these changes had not been elucidated. In the present work we used a targeted gene null mutation in mice to investigate in vivo the involvement of TIMP-1 in neuronal death and axonal sprouting following KA. We found no differences in seizure behaviour between the wild-type (WT) and the TIMP-1 knock-out (KO) mice, without any compensation by other TIMPs, at least at the mRNA level. However, the TIMP-1 KO mice were resistant to excitotoxicity and did not undergo the typical mossy fibre sprouting observed in WT mice. The lack of TIMP-1 paradoxically hampered the increase in the activity of MMPs observed in the seizing WT mice. In addition, we demonstrate that learning and memory are impaired in untreated KO mice. In conclusion, this study provides the first in vivo evidence for the implication of TIMP-1 in neuronal death and axonal sprouting in a pathological situation, but also suggests the involvement of TIMP-1 in the synaptic mechanisms underlying learning and memory in physiological conditions. More generally, these data support the idea that the control of proteolysis is instrumental for pathological and physiological processes in the brain. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 18916067
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Jourquin%2C+Jérôme%22">Jourquin, Jérôme</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tremblay%2C+Evelyne%22">Tremblay, Evelyne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernard%2C+Anne%22">Bernard, Anne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Charton%2C+Gérard%22">Charton, Gérard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chaillan%2C+Franck+A%2E%22">Chaillan, Franck A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marchetti%2C+Evelyne%22">Marchetti, Evelyne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roman%2C+François+S%2E%22">Roman, François S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soloway%2C+Paul+D%2E%22">Soloway, Paul D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dive%2C+Vincent%22">Dive, Vincent</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yiotakis%2C+Athanasios%22">Yiotakis, Athanasios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khrestchatisky%2C+Michel%22">Khrestchatisky, Michel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rivera%2C+Santiago%22">Rivera, Santiago</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2005, Vol. 22 Issue 10, p2569-2578. 10p. 1 Black and White Photograph, 5 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Metalloproteins%22">Metalloproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Learning%22">Learning</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The tissue inhibitor of metalloproteinases-1 (TIMP-1) belongs to a family of multifunctional proteins that inhibit matrix metalloproteinases (MMPs), but also regulate cell growth, proliferation, migration and apoptosis in non-nervous tissues. We had previously reported that kainate (KA)-mediated excitotoxic seizures induce the expression of TIMP-1 in resistant neurons and reactive astrocytes of the rat CNS, but the functional implications of these changes had not been elucidated. In the present work we used a targeted gene null mutation in mice to investigate in vivo the involvement of TIMP-1 in neuronal death and axonal sprouting following KA. We found no differences in seizure behaviour between the wild-type (WT) and the TIMP-1 knock-out (KO) mice, without any compensation by other TIMPs, at least at the mRNA level. However, the TIMP-1 KO mice were resistant to excitotoxicity and did not undergo the typical mossy fibre sprouting observed in WT mice. The lack of TIMP-1 paradoxically hampered the increase in the activity of MMPs observed in the seizing WT mice. In addition, we demonstrate that learning and memory are impaired in untreated KO mice. In conclusion, this study provides the first in vivo evidence for the implication of TIMP-1 in neuronal death and axonal sprouting in a pathological situation, but also suggests the involvement of TIMP-1 in the synaptic mechanisms underlying learning and memory in physiological conditions. More generally, these data support the idea that the control of proteolysis is instrumental for pathological and physiological processes in the brain. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=18916067
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1460-9568.2005.04426.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 2569
    Subjects:
      – SubjectFull: Metalloproteins
        Type: general
      – SubjectFull: Neuroplasticity
        Type: general
      – SubjectFull: Learning
        Type: general
      – SubjectFull: Memory
        Type: general
      – SubjectFull: Neural transmission
        Type: general
      – SubjectFull: Neural circuitry
        Type: general
      – SubjectFull: Neurophysiology
        Type: general
    Titles:
      – TitleFull: Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jourquin, Jérôme
      – PersonEntity:
          Name:
            NameFull: Tremblay, Evelyne
      – PersonEntity:
          Name:
            NameFull: Bernard, Anne
      – PersonEntity:
          Name:
            NameFull: Charton, Gérard
      – PersonEntity:
          Name:
            NameFull: Chaillan, Franck A.
      – PersonEntity:
          Name:
            NameFull: Marchetti, Evelyne
      – PersonEntity:
          Name:
            NameFull: Roman, François S.
      – PersonEntity:
          Name:
            NameFull: Soloway, Paul D.
      – PersonEntity:
          Name:
            NameFull: Dive, Vincent
      – PersonEntity:
          Name:
            NameFull: Yiotakis, Athanasios
      – PersonEntity:
          Name:
            NameFull: Khrestchatisky, Michel
      – PersonEntity:
          Name:
            NameFull: Rivera, Santiago
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 11
              Text: Nov2005
              Type: published
              Y: 2005
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 22
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1