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Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study.

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Title: Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study.
Authors: Tuan, Yu (AUTHOR), Chen, Li-Chi (AUTHOR), Chen, I.-Chun (AUTHOR), Tsai, Shih-Jen (AUTHOR), Chen, Tzeng-Ji (AUTHOR), Chen, Mu-Hong (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Dec2025, Vol. 55 Issue 12, p4304-4311. 8p.
Subjects: Diagnosis of autism, Age of onset, Cross-sectional method, Bipolar disorder, Substance abuse, Pearson correlation (Statistics), Secondary analysis, Income, T-test (Statistics), Research funding, Mental illness, Sex distribution, Logistic regression analysis, Severity of illness index, Schizophrenia, Age distribution, Descriptive statistics, Chi-squared test, Alcohol-induced disorders, Odds ratio, Metropolitan areas, Asperger's syndrome, Delayed diagnosis, Data analysis software, Confidence intervals, Mental depression, Disease complications, Children
Geographic Terms: Taiwan
Abstract: The mean diagnosis age of autism was about 5 years in Taiwan. Whether the delayed diagnosis of autism (≥ 6 years) was associated with parental severe mental disorders remained unknown. The parents of 22,859 autistic individuals and 228,590 age- and sex-matched nonautistic individuals were assessed for the presence of severe mental disorders (schizophrenia, bipolar disorder, major depressive disorder, alcohol use disorder, and substance use disorder). The timing of autism diagnosis was classified into three age categories: < 6 years, 6–11 years, and ≥ 12 years. Logistic regression models were used to examine associations between parental severe mental disorders and these age categories of autism diagnosis. Parental schizophrenia and substance use disorders were associated with the delayed diagnosis of autism, both diagnosis at ≥ 12 years (odds ratio [OR]: 2.14; 1.57) and at 6–11 years (1.87; 1.38). Parental bipolar disorder and major depressive disorder were also associated with the delayed diagnosis of autism, especially diagnosis at 6–11 years (OR 1.98; 1.86). Our findings underscore the need for clinicians to monitor the neurodevelopmental conditions of offspring born to parents with severe mental disorders during the early stages of their life. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study.
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  Data: The mean diagnosis age of autism was about 5 years in Taiwan. Whether the delayed diagnosis of autism (≥ 6 years) was associated with parental severe mental disorders remained unknown. The parents of 22,859 autistic individuals and 228,590 age- and sex-matched nonautistic individuals were assessed for the presence of severe mental disorders (schizophrenia, bipolar disorder, major depressive disorder, alcohol use disorder, and substance use disorder). The timing of autism diagnosis was classified into three age categories: &lt; 6 years, 6–11 years, and ≥ 12 years. Logistic regression models were used to examine associations between parental severe mental disorders and these age categories of autism diagnosis. Parental schizophrenia and substance use disorders were associated with the delayed diagnosis of autism, both diagnosis at ≥ 12 years (odds ratio [OR]: 2.14; 1.57) and at 6–11 years (1.87; 1.38). Parental bipolar disorder and major depressive disorder were also associated with the delayed diagnosis of autism, especially diagnosis at 6–11 years (OR 1.98; 1.86). Our findings underscore the need for clinicians to monitor the neurodevelopmental conditions of offspring born to parents with severe mental disorders during the early stages of their life. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Autism &amp; Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-024-06518-9
    Languages:
      – Code: eng
        Text: English
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        StartPage: 4304
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      – SubjectFull: Diagnosis of autism
        Type: general
      – SubjectFull: Age of onset
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Bipolar disorder
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      – SubjectFull: Substance abuse
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      – SubjectFull: Pearson correlation (Statistics)
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      – SubjectFull: Secondary analysis
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      – SubjectFull: Income
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      – SubjectFull: T-test (Statistics)
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      – SubjectFull: Research funding
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      – SubjectFull: Mental illness
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Schizophrenia
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      – SubjectFull: Odds ratio
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      – SubjectFull: Metropolitan areas
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      – SubjectFull: Asperger's syndrome
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      – SubjectFull: Delayed diagnosis
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      – SubjectFull: Children
        Type: general
      – SubjectFull: Taiwan
        Type: general
    Titles:
      – TitleFull: Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study.
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            – D: 01
              M: 12
              Text: Dec2025
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