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Sleep Disorders and Constipation in Autistic Children and Youth: Who Receives Standard of Care Drug Treatments?

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Title: Sleep Disorders and Constipation in Autistic Children and Youth: Who Receives Standard of Care Drug Treatments?
Authors: Angell, Amber M. (AUTHOR), Wee, Choo Phei (AUTHOR), Deavenport-Saman, Alexis (AUTHOR), Parchment, Camille (AUTHOR), Bai, Chen (AUTHOR), Solomon, Olga (AUTHOR), Yin, Larry (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Dec2025, Vol. 55 Issue 12, p4365-4371. 7p.
Subjects: Medical care standards, Research funding, Children with disabilities, African Americans, Medical quality control, Autism, Sex distribution, Drug therapy, Health insurance, Fisher exact test, Hispanic Americans, Logistic regression analysis, Retrospective studies, Age distribution, Population geography, Chi-squared test, Mann Whitney U Test, Descriptive statistics, Longitudinal method, Odds ratio, Race, Medical records, Acquisition of data, Rural conditions, Metropolitan areas, Physician practice patterns, Asperger's syndrome, Comparative studies, Drugs, Medicaid, Confidence intervals, Drug prescribing, Data analysis software, Sleep disorders, Constipation, People with disabilities, Nonprescription drugs, Comorbidity, Adolescence, Children, Adults
Geographic Terms: Florida
Abstract: Purpose: The purpose of this retrospective cohort analysis was to investigate sex differences in receipt of standard of care sleep and constipation drug treatments among autistic children and youth with sleep disorder and constipation, respectively. Methods: We used the data from the OneFlorida + Data Trust to analyze healthcare claims for 19,877 autistic patients with sleep disorder and 32,355 patients with constipation, ages 1 to 22. We used logistic regression to examine sex differences in receiving sleep and constipation treatments, and a multivariate logistic regression model to further assess sex differences in ever receiving sleep and constipation treatments, adjusting for age, race, ethnicity, and urbanicity. Results: In our multivariate analysis, autistic girls with sleep disorder were 1.27 times more likely than boys to receive sleep treatment (p < 0.0001). Although autistic girls with constipation appeared to be 1.10 times more likely than boys to receive treatment, it was not significantly different after adjusting for demographic and socio-economic characteristics (p = 0.372). Older children were 1.09 times more likely than younger children to receive sleep treatment (p < 0.0001) and 1.07 times more likely to receive constipation treatment (p < 0.0001). Conclusion: We did not find sex differences among autistic children for treatment of constipation, but autistic girls with sleep disorder were significantly more likely to have ever received treatment, which could indicate that girls experience more significant sleep disorders. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Purpose: The purpose of this retrospective cohort analysis was to investigate sex differences in receipt of standard of care sleep and constipation drug treatments among autistic children and youth with sleep disorder and constipation, respectively. Methods: We used the data from the OneFlorida + Data Trust to analyze healthcare claims for 19,877 autistic patients with sleep disorder and 32,355 patients with constipation, ages 1 to 22. We used logistic regression to examine sex differences in receiving sleep and constipation treatments, and a multivariate logistic regression model to further assess sex differences in ever receiving sleep and constipation treatments, adjusting for age, race, ethnicity, and urbanicity. Results: In our multivariate analysis, autistic girls with sleep disorder were 1.27 times more likely than boys to receive sleep treatment (p &lt; 0.0001). Although autistic girls with constipation appeared to be 1.10 times more likely than boys to receive treatment, it was not significantly different after adjusting for demographic and socio-economic characteristics (p = 0.372). Older children were 1.09 times more likely than younger children to receive sleep treatment (p &lt; 0.0001) and 1.07 times more likely to receive constipation treatment (p &lt; 0.0001). Conclusion: We did not find sex differences among autistic children for treatment of constipation, but autistic girls with sleep disorder were significantly more likely to have ever received treatment, which could indicate that girls experience more significant sleep disorders. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Autism &amp; Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189168314
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      – Type: doi
        Value: 10.1007/s10803-025-06762-7
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 4365
    Subjects:
      – SubjectFull: Medical care standards
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Children with disabilities
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      – SubjectFull: African Americans
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      – SubjectFull: Sex distribution
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      – SubjectFull: Drug therapy
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      – SubjectFull: Hispanic Americans
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      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Population geography
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      – SubjectFull: Chi-squared test
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Race
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      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Acquisition of data
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      – SubjectFull: Metropolitan areas
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      – SubjectFull: Physician practice patterns
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      – SubjectFull: Drugs
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      – SubjectFull: Medicaid
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Drug prescribing
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Sleep disorders
        Type: general
      – SubjectFull: Constipation
        Type: general
      – SubjectFull: People with disabilities
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      – SubjectFull: Nonprescription drugs
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      – SubjectFull: Adults
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      – SubjectFull: Florida
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      – TitleFull: Sleep Disorders and Constipation in Autistic Children and Youth: Who Receives Standard of Care Drug Treatments?
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            – D: 01
              M: 12
              Text: Dec2025
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