Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study.
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| Title: | Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study. |
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| Authors: | De la Serna, E. (AUTHOR), Moreno, D. (AUTHOR), Sugranyes, G. (AUTHOR), Camprodon-Boadas, P. (AUTHOR), Ilzarbe, D. (AUTHOR), Bigorra, A. (AUTHOR), Mora-Maltas, B. (AUTHOR), Baeza, I. (AUTHOR), Flamarique, I. (AUTHOR), Parrilla, S. (AUTHOR), Díaz-Caneja, C. M. (AUTHOR), Moreno, C. (AUTHOR), Borras, R. (AUTHOR), Torrent, C. (AUTHOR), Garcia-Rizo, C. (AUTHOR), Castro-Fornieles, J. (AUTHOR) |
| Source: | European Child & Adolescent Psychiatry. Oct2025, Vol. 34 Issue 10, p3035-3045. 11p. |
| Subjects: | Risk factors of attention-deficit hyperactivity disorder, Risk assessment, Behavior disorders, Schizophrenia in children, Research funding, Psychology of fathers, Interviewing, Parenting, Descriptive statistics, Multivariate analysis, Parent attitudes, Kaplan-Meier estimator, Longitudinal method, Log-rank test, Statistics, Psychology of mothers, Parents of children with disabilities, Psychoses, Confidence intervals, Psychosocial factors, Pathological psychology, Bipolar disorder in children, Social classes, Disease incidence |
| Abstract: | Offspring of patients diagnosed with schizophrenia (SZoff) or bipolar disorder (BDoff) have double the risk of developing a psychiatric disorder. Here we report the effects of some parental characteristics on the offspring risk of psychopathology at 4-year follow-up. At baseline, 90 BDoff, 41 SZoff and 107 Community Control offspring (CCoff) aged 6 to 17 were included. At 4-year follow-up, 71% of the sample was assessed. Parents' and offspring's psychiatric diagnoses as well as socio-economic status (SES) and global functioning were assessed in addition to parents' ages at childbirth and offspring subclinical psychotic/bipolar symptoms. Kaplan-Meier method and Cox regression analysis were used to assess between-group differences in the cumulative incidence of psychiatric disorders and subclinical psychotic/bipolar symptoms and the association of some offspring and parents' variables with risk of psychopathology and subclinical psychotic/bipolar symptoms. SZoff and BDoff had a higher risk of psychopathology than CCoff at 4-year follow-up. SZoff showed a higher risk for attention deficit hyperactivity disorder (ADHD), disruptive disorders and subclinical psychotic symptoms, whereas BDoff displayed a heightened risk for mood disorders, ADHD and subclinical bipolar symptoms when compared to CCoff. Higher parental psychosocial functioning and SES were associated with a lower prevalence of psychopathology. Both SZoff and BDoff samples have a higher risk for psychopathology but the pattern of this psychopathology seems to be group specific. Longer follow-up studies and larger sample sizes are needed to assess the capacity of psychopathological disorder and subclinical psychotic or bipolar symptoms to predict progression to fully-fledged disorders. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Offspring of patients diagnosed with schizophrenia (SZoff) or bipolar disorder (BDoff) have double the risk of developing a psychiatric disorder. Here we report the effects of some parental characteristics on the offspring risk of psychopathology at 4-year follow-up. At baseline, 90 BDoff, 41 SZoff and 107 Community Control offspring (CCoff) aged 6 to 17 were included. At 4-year follow-up, 71% of the sample was assessed. Parents' and offspring's psychiatric diagnoses as well as socio-economic status (SES) and global functioning were assessed in addition to parents' ages at childbirth and offspring subclinical psychotic/bipolar symptoms. Kaplan-Meier method and Cox regression analysis were used to assess between-group differences in the cumulative incidence of psychiatric disorders and subclinical psychotic/bipolar symptoms and the association of some offspring and parents' variables with risk of psychopathology and subclinical psychotic/bipolar symptoms. SZoff and BDoff had a higher risk of psychopathology than CCoff at 4-year follow-up. SZoff showed a higher risk for attention deficit hyperactivity disorder (ADHD), disruptive disorders and subclinical psychotic symptoms, whereas BDoff displayed a heightened risk for mood disorders, ADHD and subclinical bipolar symptoms when compared to CCoff. Higher parental psychosocial functioning and SES were associated with a lower prevalence of psychopathology. Both SZoff and BDoff samples have a higher risk for psychopathology but the pattern of this psychopathology seems to be group specific. Longer follow-up studies and larger sample sizes are needed to assess the capacity of psychopathological disorder and subclinical psychotic or bipolar symptoms to predict progression to fully-fledged disorders. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10188827 |
| DOI: | 10.1007/s00787-025-02719-4 |
