Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder.
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| Title: | Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder. |
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| Authors: | Vidor, Marcos Vinícius (AUTHOR), Vitola, Eduardo Schneider (AUTHOR), Bandeira, Cibele Edom (AUTHOR), Martins, Alexandre Ribeiro (AUTHOR), de Araujo Tavares, Maria Eduarda (AUTHOR), Cupertino, Renata Basso (AUTHOR), Panzenhagen, Alana Castro (AUTHOR), da Silva, Bruna Santos (AUTHOR), Falkenberg, Isabel Ghirardi (AUTHOR), Barreto, Pedro Olavo (AUTHOR), Teche, Stefania Pigatto (AUTHOR), Picon, Felipe Almeida (AUTHOR), Rohde, Luis Augusto (AUTHOR), Rovaris, Diego L. (AUTHOR), Bau, Claiton Henrique Dotto (AUTHOR), Grevet, Eugenio Horacio (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Oct2025, Vol. 275 Issue 7, p1863-1871. 9p. |
| Abstract: | The default mode network (DMN) is atypically active in patients with ADHD, likely contributing to the inattention patterns observed in patients with the disorder. Nonetheless, magnetic resonance spectroscopy (MRS) studies have rarely targeted the posterior cingulate cortex, a key DMN region, and little is known about the biochemical setting within this network in patients with ADHD. We aimed to assess the differences in metabolite profiles of the posterior cingulate cortex—a key region of the DMN—between patients with ADHD and controls. Five brain metabolites—glutamate, inositol, N-acetyl aspartate, choline, and creatine—were measured through MRS in the posterior cingulate cortex of patients and controls in a 3.0 T scanner. Between-group comparison of neurometabolite concentrations in PCC was performed using multivariate analysis of covariance. A total of 88 patients and 44 controls were included in the analysis. Patients with ADHD showed lower levels of glutamate in the posterior cingulate cortex compared to controls (p = 0.003). Lower concentrations of glutamate in the posterior cingulate cortex suggest that a glutamatergic imbalance within the posterior cingulate cortex might play a role in the pathogenesis of ADHD. Further understanding of the causes and consequences of such glutamate decrease might help explain how some glutamate-related drug effects impact on ADHD symptomatology. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 189168809 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vidor%2C+Marcos+Vinícius%22">Vidor, Marcos Vinícius</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vitola%2C+Eduardo+Schneider%22">Vitola, Eduardo Schneider</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bandeira%2C+Cibele+Edom%22">Bandeira, Cibele Edom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martins%2C+Alexandre+Ribeiro%22">Martins, Alexandre Ribeiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Araujo+Tavares%2C+Maria+Eduarda%22">de Araujo Tavares, Maria Eduarda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cupertino%2C+Renata+Basso%22">Cupertino, Renata Basso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panzenhagen%2C+Alana+Castro%22">Panzenhagen, Alana Castro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22da+Silva%2C+Bruna+Santos%22">da Silva, Bruna Santos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falkenberg%2C+Isabel+Ghirardi%22">Falkenberg, Isabel Ghirardi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barreto%2C+Pedro+Olavo%22">Barreto, Pedro Olavo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teche%2C+Stefania+Pigatto%22">Teche, Stefania Pigatto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Picon%2C+Felipe+Almeida%22">Picon, Felipe Almeida</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohde%2C+Luis+Augusto%22">Rohde, Luis Augusto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rovaris%2C+Diego+L%2E%22">Rovaris, Diego L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bau%2C+Claiton+Henrique+Dotto%22">Bau, Claiton Henrique Dotto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grevet%2C+Eugenio+Horacio%22">Grevet, Eugenio Horacio</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2025, Vol. 275 Issue 7, p1863-1871. 9p. – Name: Abstract Label: Abstract Group: Ab Data: The default mode network (DMN) is atypically active in patients with ADHD, likely contributing to the inattention patterns observed in patients with the disorder. Nonetheless, magnetic resonance spectroscopy (MRS) studies have rarely targeted the posterior cingulate cortex, a key DMN region, and little is known about the biochemical setting within this network in patients with ADHD. We aimed to assess the differences in metabolite profiles of the posterior cingulate cortex—a key region of the DMN—between patients with ADHD and controls. Five brain metabolites—glutamate, inositol, N-acetyl aspartate, choline, and creatine—were measured through MRS in the posterior cingulate cortex of patients and controls in a 3.0 T scanner. Between-group comparison of neurometabolite concentrations in PCC was performed using multivariate analysis of covariance. A total of 88 patients and 44 controls were included in the analysis. Patients with ADHD showed lower levels of glutamate in the posterior cingulate cortex compared to controls (p = 0.003). Lower concentrations of glutamate in the posterior cingulate cortex suggest that a glutamatergic imbalance within the posterior cingulate cortex might play a role in the pathogenesis of ADHD. Further understanding of the causes and consequences of such glutamate decrease might help explain how some glutamate-related drug effects impact on ADHD symptomatology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-024-01805-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1863 Titles: – TitleFull: Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vidor, Marcos Vinícius – PersonEntity: Name: NameFull: Vitola, Eduardo Schneider – PersonEntity: Name: NameFull: Bandeira, Cibele Edom – PersonEntity: Name: NameFull: Martins, Alexandre Ribeiro – PersonEntity: Name: NameFull: de Araujo Tavares, Maria Eduarda – PersonEntity: Name: NameFull: Cupertino, Renata Basso – PersonEntity: Name: NameFull: Panzenhagen, Alana Castro – PersonEntity: Name: NameFull: da Silva, Bruna Santos – PersonEntity: Name: NameFull: Falkenberg, Isabel Ghirardi – PersonEntity: Name: NameFull: Barreto, Pedro Olavo – PersonEntity: Name: NameFull: Teche, Stefania Pigatto – PersonEntity: Name: NameFull: Picon, Felipe Almeida – PersonEntity: Name: NameFull: Rohde, Luis Augusto – PersonEntity: Name: NameFull: Rovaris, Diego L. – PersonEntity: Name: NameFull: Bau, Claiton Henrique Dotto – PersonEntity: Name: NameFull: Grevet, Eugenio Horacio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 275 – Type: issue Value: 7 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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