Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations.
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| Title: | Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations. |
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| Authors: | Chen, Qiao-Ru (AUTHOR), Wang, Yi (AUTHOR), Yang, Bin-Rang (AUTHOR), Wang, Yu-Feng (AUTHOR), Chan, Raymond C. K. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Oct2025, Vol. 275 Issue 7, p1897-1911. 15p. |
| Abstract: | Attention deficit and hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by attention deficits, hyperactivity, and impulsivity. This study investigated brain structural differences in children with ADHD compared to typically developing children. Our sample included 199 ADHD children (114 ADHD-predominantly inattentive; 85 ADHD-combined presentation subtypes) and 94 typically developing controls. All participants completed clinical assessments and MRI scans. We conducted whole-brain voxel-based morphometry (VBM) analysis, structural covariance analysis, and clinical correlation. We used Analysis of Covariance (ANCOVA) and Multivariate Analysis of Covariance (MANCOVA) to compare gray matter volume (GMV) and structural covariance between the ADHD subgroups and typically developing children. We also analyzed correlations between structural covariance and clinical symptoms. The results showed significant GMV differences, particularly in the frontal cortex and basal ganglia, among ADHD subtypes and typically developing children. Compared to controls, children with ADHD combined presentation (ADHD-C) exhibited significantly larger GMV in the right precentral gyrus, right inferior frontal gyrus, right superior frontal gyrus, and left cingulate gyrus, while children with ADHD-predominantly inattentive (ADHD-I) exhibited larger GMV in the right cingulate gyrus. Within the ADHD subtypes, ADHD-C children displayed larger GMV in the left caudate nucleus compared to ADHD-I children. Structural covariance analysis highlighted the altered connectivity patterns, involving the striatum and regions within the default mode network. Correlation analysis indicated associations between altered brain structures and symptoms, cognitive abilities, and social functioning. Our findings suggested that specific brain regions are implicated in ADHD pathology and associated with clinical symptoms, paving ways for developing diagnostic markers and future interventions. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 189168829 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+Qiao-Ru%22">Chen, Qiao-Ru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yi%22">Wang, Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Bin-Rang%22">Yang, Bin-Rang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yu-Feng%22">Wang, Yu-Feng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Raymond+C%2E+K%2E%22">Chan, Raymond C. K.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2025, Vol. 275 Issue 7, p1897-1911. 15p. – Name: Abstract Label: Abstract Group: Ab Data: Attention deficit and hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by attention deficits, hyperactivity, and impulsivity. This study investigated brain structural differences in children with ADHD compared to typically developing children. Our sample included 199 ADHD children (114 ADHD-predominantly inattentive; 85 ADHD-combined presentation subtypes) and 94 typically developing controls. All participants completed clinical assessments and MRI scans. We conducted whole-brain voxel-based morphometry (VBM) analysis, structural covariance analysis, and clinical correlation. We used Analysis of Covariance (ANCOVA) and Multivariate Analysis of Covariance (MANCOVA) to compare gray matter volume (GMV) and structural covariance between the ADHD subgroups and typically developing children. We also analyzed correlations between structural covariance and clinical symptoms. The results showed significant GMV differences, particularly in the frontal cortex and basal ganglia, among ADHD subtypes and typically developing children. Compared to controls, children with ADHD combined presentation (ADHD-C) exhibited significantly larger GMV in the right precentral gyrus, right inferior frontal gyrus, right superior frontal gyrus, and left cingulate gyrus, while children with ADHD-predominantly inattentive (ADHD-I) exhibited larger GMV in the right cingulate gyrus. Within the ADHD subtypes, ADHD-C children displayed larger GMV in the left caudate nucleus compared to ADHD-I children. Structural covariance analysis highlighted the altered connectivity patterns, involving the striatum and regions within the default mode network. Correlation analysis indicated associations between altered brain structures and symptoms, cognitive abilities, and social functioning. Our findings suggested that specific brain regions are implicated in ADHD pathology and associated with clinical symptoms, paving ways for developing diagnostic markers and future interventions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-025-02029-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1897 Titles: – TitleFull: Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, Qiao-Ru – PersonEntity: Name: NameFull: Wang, Yi – PersonEntity: Name: NameFull: Yang, Bin-Rang – PersonEntity: Name: NameFull: Wang, Yu-Feng – PersonEntity: Name: NameFull: Chan, Raymond C. K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 275 – Type: issue Value: 7 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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