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Clinically ready magnetic microrobots for targeted therapies.

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Title: Clinically ready magnetic microrobots for targeted therapies.
Authors: Landers, Fabian C. (AUTHOR), Hertle, Lukas (AUTHOR), Pustovalov, Vitaly (AUTHOR), Sivakumaran, Derick (AUTHOR), Oral, Cagatay M. (AUTHOR), Brinkmann, Oliver (AUTHOR), Meiners, Kirstin (AUTHOR), Theiler, Pascal (AUTHOR), Gantenbein, Valentin (AUTHOR), Veciana, Andrea (AUTHOR), Mattmann, Michael (AUTHOR), Riss, Silas (AUTHOR), Gervasoni, Simone (AUTHOR), Chautems, Christophe (AUTHOR), Ye, Hao (AUTHOR), Sevim, Semih (AUTHOR), Flouris, Andreas D. (AUTHOR), Puigmartí-Luis, Josep (AUTHOR), Mayor, Tiago Sotto (AUTHOR), Alves, Pedro (AUTHOR)
Source: Science. 11/13/2025, Vol. 390 Issue 6774, p710-715. 6p.
Subjects: Targeted drug delivery, Drug delivery systems, In vivo studies, Biocompatibility, Tracking control systems, Microrobots
Abstract: Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery platform capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, offering a promising solution for precise targeted drug delivery. Editor's summary: A challenge in the design of microrobots is balancing biocompatibility, biodegradability, size, and magnetic properties required for precise control. Ideally, one would also like to achieve real-time tracking, efficient navigation, and robust drug-loading capabilities. Landers et al. designed a microrobotic system that combines electromagnetic navigation, a release catheter, and dissolvable drug-loaded capsules. They demonstrated precise navigation in human vasculature models and tracking and navigation in large animal models. —Marc Lavine [ABSTRACT FROM AUTHOR]
Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Data: Clinically ready magnetic microrobots for targeted therapies.
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  Data: <searchLink fieldCode="AR" term="%22Landers%2C+Fabian+C%2E%22">Landers, Fabian C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hertle%2C+Lukas%22">Hertle, Lukas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pustovalov%2C+Vitaly%22">Pustovalov, Vitaly</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sivakumaran%2C+Derick%22">Sivakumaran, Derick</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oral%2C+Cagatay+M%2E%22">Oral, Cagatay M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brinkmann%2C+Oliver%22">Brinkmann, Oliver</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meiners%2C+Kirstin%22">Meiners, Kirstin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Theiler%2C+Pascal%22">Theiler, Pascal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gantenbein%2C+Valentin%22">Gantenbein, Valentin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Veciana%2C+Andrea%22">Veciana, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mattmann%2C+Michael%22">Mattmann, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riss%2C+Silas%22">Riss, Silas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gervasoni%2C+Simone%22">Gervasoni, Simone</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chautems%2C+Christophe%22">Chautems, Christophe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Hao%22">Ye, Hao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sevim%2C+Semih%22">Sevim, Semih</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Flouris%2C+Andreas+D%2E%22">Flouris, Andreas D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Puigmartí-Luis%2C+Josep%22">Puigmartí-Luis, Josep</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayor%2C+Tiago+Sotto%22">Mayor, Tiago Sotto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alves%2C+Pedro%22">Alves, Pedro</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Science%22">Science</searchLink>. 11/13/2025, Vol. 390 Issue 6774, p710-715. 6p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery platform capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, offering a promising solution for precise targeted drug delivery. Editor's summary: A challenge in the design of microrobots is balancing biocompatibility, biodegradability, size, and magnetic properties required for precise control. Ideally, one would also like to achieve real-time tracking, efficient navigation, and robust drug-loading capabilities. Landers et al. designed a microrobotic system that combines electromagnetic navigation, a release catheter, and dissolvable drug-loaded capsules. They demonstrated precise navigation in human vasculature models and tracking and navigation in large animal models. —Marc Lavine [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189291586
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        Value: 10.1126/science.adx1708
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        Text: English
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      – SubjectFull: Targeted drug delivery
        Type: general
      – SubjectFull: Drug delivery systems
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      – SubjectFull: In vivo studies
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