View in EDS HTML Full Text PDF Full Text

Preoperative Short‐Term Efgartigimod Benefits Myasthenia Gravis Patients Undergoing Thymectomy.

Saved in:
Bibliographic Details
Title: Preoperative Short‐Term Efgartigimod Benefits Myasthenia Gravis Patients Undergoing Thymectomy.
Authors: Zhang, Xiao-He (AUTHOR), Zhang, Hao (AUTHOR), Li, Jia-Duo (AUTHOR), Pan, Zu-Lin (AUTHOR), Liu, Yong-Bing (AUTHOR), Xue, Ying-Ping (AUTHOR), Zheng, Xu-Guang (AUTHOR), Zhang, Xiao-Jing (AUTHOR), Qi, Guo-Yan (AUTHOR), Cumming, Paul (AUTHOR)
Source: Acta Neurologica Scandinavica. 11/15/2025, Vol. 2025, p1-9. 9p.
Subjects: Myasthenia gravis, Thymectomy, Surgical intensive care, Antibody titer, Medical research, Immunomodulators, Preoperative care, Muscle strength
Abstract: Background and Objectives: Thymectomy is an effective way to alleviate muscle weakness for myasthenia gravis (MG) patients with and without thymoma. However, thymectomy may exacerbate MG. Efgartigimod as a neonatal Fc receptor (FcRn) blocker has been found to be effective in generalized MG, and this study aims to explore whether application of efgartigimod before surgery can also benefit MG patients who undergo thymectomy. Methods: We retrospectively included 140 patients from Shijiazhuang People's Hospital in this study. Using propensity score matching (PSM) with a 1:3 nearest‐neighbor ratio, 44 patients were selected: 11 were allocated to the efgartigimod group and 33 to the non‐efgartigimod group. Clinical features, quantitative antibody test results, MGFA class at different periods, thymic pathology, operation information, and muscle functional change as evaluated by both MG ADL and QMG scores were collected. Patients were divided into two groups: the efgartigimod group and the nonefgartigimod group. Result: Patients who received efgartigimod therapy prior to their operations had a greater decline in MG ADL score (adjusted β coefficient = 5.27 [1.32,9.21], adjusted p = 0.012). After PSM, patients in the efgartigimod group showed lower surgery decision‐to‐finished‐surgery times (p < 0.001), postoperative therapy time in the ICU (p = 0.007), better MGFA class after surgery (p = 0.001), more functional improvement in QMG scores (p < 0.001), and larger declines in antibody titer (p < 0.001). Conclusion: For MG patients awaiting thymectomy, short‐term efgartigimod serves as an effective bridging therapy. It optimizes patients' preoperative conditions, potentially shortens the waiting time for surgery as well as postoperative ICU stay and presents a viable alternative to conventional preoperative optimization strategies such as high‐dose prednisolone, plasma exchange, and intravenous immunoglobulin. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 189332054
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Preoperative Short‐Term Efgartigimod Benefits Myasthenia Gravis Patients Undergoing Thymectomy.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Xiao-He%22&quot;&gt;Zhang, Xiao-He&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Hao%22&quot;&gt;Zhang, Hao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Jia-Duo%22&quot;&gt;Li, Jia-Duo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pan%2C+Zu-Lin%22&quot;&gt;Pan, Zu-Lin&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Yong-Bing%22&quot;&gt;Liu, Yong-Bing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xue%2C+Ying-Ping%22&quot;&gt;Xue, Ying-Ping&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zheng%2C+Xu-Guang%22&quot;&gt;Zheng, Xu-Guang&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Xiao-Jing%22&quot;&gt;Zhang, Xiao-Jing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Qi%2C+Guo-Yan%22&quot;&gt;Qi, Guo-Yan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cumming%2C+Paul%22&quot;&gt;Cumming, Paul&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Neurologica+Scandinavica%22&quot;&gt;Acta Neurologica Scandinavica&lt;/searchLink&gt;. 11/15/2025, Vol. 2025, p1-9. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myasthenia+gravis%22&quot;&gt;Myasthenia gravis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Thymectomy%22&quot;&gt;Thymectomy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Surgical+intensive+care%22&quot;&gt;Surgical intensive care&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antibody+titer%22&quot;&gt;Antibody titer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+research%22&quot;&gt;Medical research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Immunomodulators%22&quot;&gt;Immunomodulators&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Preoperative+care%22&quot;&gt;Preoperative care&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Muscle+strength%22&quot;&gt;Muscle strength&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Objectives: Thymectomy is an effective way to alleviate muscle weakness for myasthenia gravis (MG) patients with and without thymoma. However, thymectomy may exacerbate MG. Efgartigimod as a neonatal Fc receptor (FcRn) blocker has been found to be effective in generalized MG, and this study aims to explore whether application of efgartigimod before surgery can also benefit MG patients who undergo thymectomy. Methods: We retrospectively included 140 patients from Shijiazhuang People&#39;s Hospital in this study. Using propensity score matching (PSM) with a 1:3 nearest‐neighbor ratio, 44 patients were selected: 11 were allocated to the efgartigimod group and 33 to the non‐efgartigimod group. Clinical features, quantitative antibody test results, MGFA class at different periods, thymic pathology, operation information, and muscle functional change as evaluated by both MG ADL and QMG scores were collected. Patients were divided into two groups: the efgartigimod group and the nonefgartigimod group. Result: Patients who received efgartigimod therapy prior to their operations had a greater decline in MG ADL score (adjusted β coefficient = 5.27 [1.32,9.21], adjusted p = 0.012). After PSM, patients in the efgartigimod group showed lower surgery decision‐to‐finished‐surgery times (p &lt; 0.001), postoperative therapy time in the ICU (p = 0.007), better MGFA class after surgery (p = 0.001), more functional improvement in QMG scores (p &lt; 0.001), and larger declines in antibody titer (p &lt; 0.001). Conclusion: For MG patients awaiting thymectomy, short‐term efgartigimod serves as an effective bridging therapy. It optimizes patients&#39; preoperative conditions, potentially shortens the waiting time for surgery as well as postoperative ICU stay and presents a viable alternative to conventional preoperative optimization strategies such as high‐dose prednisolone, plasma exchange, and intravenous immunoglobulin. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189332054
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ane/8889388
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1
    Subjects:
      – SubjectFull: Myasthenia gravis
        Type: general
      – SubjectFull: Thymectomy
        Type: general
      – SubjectFull: Surgical intensive care
        Type: general
      – SubjectFull: Antibody titer
        Type: general
      – SubjectFull: Medical research
        Type: general
      – SubjectFull: Immunomodulators
        Type: general
      – SubjectFull: Preoperative care
        Type: general
      – SubjectFull: Muscle strength
        Type: general
    Titles:
      – TitleFull: Preoperative Short‐Term Efgartigimod Benefits Myasthenia Gravis Patients Undergoing Thymectomy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhang, Xiao-He
      – PersonEntity:
          Name:
            NameFull: Zhang, Hao
      – PersonEntity:
          Name:
            NameFull: Li, Jia-Duo
      – PersonEntity:
          Name:
            NameFull: Pan, Zu-Lin
      – PersonEntity:
          Name:
            NameFull: Liu, Yong-Bing
      – PersonEntity:
          Name:
            NameFull: Xue, Ying-Ping
      – PersonEntity:
          Name:
            NameFull: Zheng, Xu-Guang
      – PersonEntity:
          Name:
            NameFull: Zhang, Xiao-Jing
      – PersonEntity:
          Name:
            NameFull: Qi, Guo-Yan
      – PersonEntity:
          Name:
            NameFull: Cumming, Paul
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 11
              Text: 11/15/2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 2025
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1