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Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.

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Title: Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.
Authors: Ma, Shaojie (AUTHOR), Hu, Wenjuan (AUTHOR), Bi, Yingwei (AUTHOR), Han, Ying (AUTHOR), Wang, Wei (AUTHOR), Xin, Deli (AUTHOR)
Source: Journal of Asthma. Dec2025, Vol. 62 Issue 12, p2070-2083. 14p.
Subjects: Asthma in children, Mendelian randomization, Metabolites, Causal models, Biomarkers, Genome-wide association studies, Therapeutics, Genetic variation
Abstract: Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches. Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites. The inverse-variance weighting (IVW) method assessed causal relationships between plasma metabolites and PA, with measures taken to mitigate horizontal pleiotropy and heterogeneity. To select instrumental variables, a genome-wide significance threshold (p < 5 × 10–8) was applied to ensure robust genetic instruments. A Bonferroni correction controlled for multiple testing, with statistical significance defined as p < 3.57 × 10–5) (0.05/1400). To further substantiate outcomes, a reverse Mendelian randomization analysis was conducted. Results: Research found 91 plasma metabolites linked to PA, ten of which showed significant associations. Of note, 20:4n6 levels (IVW: OR (95% CI) = 1.062 (1.030 to 1.094) and G/C16 (IVW: OR (95% CI) = 0.886 (0.832 to 0.943) were identified as pivotal exposure factors for PA. Conclusions: This study highlights 10 plasma metabolites that may have significant associations with PA incidence, with 20:4n6 levels and G/C16 potentially serving as valuable biomarkers for the early detection and management of PA. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.
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  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ma%2C+Shaojie%22&quot;&gt;Ma, Shaojie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Wenjuan%22&quot;&gt;Hu, Wenjuan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bi%2C+Yingwei%22&quot;&gt;Bi, Yingwei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Han%2C+Ying%22&quot;&gt;Han, Ying&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Wei%22&quot;&gt;Wang, Wei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xin%2C+Deli%22&quot;&gt;Xin, Deli&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Asthma%22&quot;&gt;Journal of Asthma&lt;/searchLink&gt;. Dec2025, Vol. 62 Issue 12, p2070-2083. 14p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Asthma+in+children%22&quot;&gt;Asthma in children&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mendelian+randomization%22&quot;&gt;Mendelian randomization&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Metabolites%22&quot;&gt;Metabolites&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Causal+models%22&quot;&gt;Causal models&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genome-wide+association+studies%22&quot;&gt;Genome-wide association studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Therapeutics%22&quot;&gt;Therapeutics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetic+variation%22&quot;&gt;Genetic variation&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches. Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites. The inverse-variance weighting (IVW) method assessed causal relationships between plasma metabolites and PA, with measures taken to mitigate horizontal pleiotropy and heterogeneity. To select instrumental variables, a genome-wide significance threshold (p &lt; 5 &#215; 10–8) was applied to ensure robust genetic instruments. A Bonferroni correction controlled for multiple testing, with statistical significance defined as p &lt; 3.57 &#215; 10–5) (0.05/1400). To further substantiate outcomes, a reverse Mendelian randomization analysis was conducted. Results: Research found 91 plasma metabolites linked to PA, ten of which showed significant associations. Of note, 20:4n6 levels (IVW: OR (95% CI) = 1.062 (1.030 to 1.094) and G/C16 (IVW: OR (95% CI) = 0.886 (0.832 to 0.943) were identified as pivotal exposure factors for PA. Conclusions: This study highlights 10 plasma metabolites that may have significant associations with PA incidence, with 20:4n6 levels and G/C16 potentially serving as valuable biomarkers for the early detection and management of PA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Journal of Asthma is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/02770903.2025.2552748
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 2070
    Subjects:
      – SubjectFull: Asthma in children
        Type: general
      – SubjectFull: Mendelian randomization
        Type: general
      – SubjectFull: Metabolites
        Type: general
      – SubjectFull: Causal models
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Genome-wide association studies
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      – SubjectFull: Therapeutics
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      – SubjectFull: Genetic variation
        Type: general
    Titles:
      – TitleFull: Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study.
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            NameFull: Ma, Shaojie
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            NameFull: Hu, Wenjuan
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            NameFull: Bi, Yingwei
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            NameFull: Han, Ying
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            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
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